Role of thyroidectomy in advanced laryngeal and pharyngolaryngeal carcinoma

Elliott, Michael; Odell, Edward; Tysome, James R.; Connor, Steve; Siddiqui, Ata; Jeannon, Jean‐Pierre; Simó, Ricard

doi:10.1016/j.otohns.2010.02.006

Cited by 39 publications

(61 citation statements)

References 19 publications

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“…3,4 Routes of spread of laryngeal cancer to the thyroid include direct extension, and haematogenous or lymphatic spread. Proposed clinical and pathological factors predisposing to thyroid gland involvement include cricothyroid membrane invasion, subglottic extension, advanced stage and vocal fold fixation.…”

Section: Introductionmentioning

confidence: 99%

Management of the thyroid gland during laryngectomy

Polacco

Gosselin

et al. 2017

J. Laryngol. Otol.

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Objectives This study aimed to: describe the incidence of thyroid gland involvement in advanced laryngeal cancer, analyse patterns of spread to the thyroid and elucidate predictors of thyroid involvement. Methods A retrospective review was performed on patients who underwent laryngectomy from 1991 to 2015 as a primary or salvage treatment for squamous cell carcinoma of the larynx, hypopharynx or base of tongue. The incidence of thyroidectomy during total laryngectomy, type of thyroidectomy, incidence of gland involvement, route of spread, and positive predictors of spread were analysed and reported. Results A total of 188 patients fit the inclusion criteria. Of these, 125 (66 per cent) underwent thyroidectomy. The thyroid was involved in 10 of the 125 patients (8 per cent), 9 by direct extension and 1 by metastasis. Cartilage invasion was a predictor of thyroid gland involvement, with a positive predictive value of 26 per cent. Conclusion There is a low incidence of thyroid gland involvement in laryngeal carcinoma. Most cases of gland involvement occurred by direct extension. Thyroidectomy during laryngectomy should be considered for advanced stage tumours with cartilage invasion.

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Section: Introductionmentioning

confidence: 99%

Management of the thyroid gland during laryngectomy

Polacco

Gosselin

et al. 2017

J. Laryngol. Otol.

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“…A total thyroidectomy during a total laryngectomy may be required because of neoplastic invasion of the thyroid gland. However, the rate of TGI is low, and pointless resection of the thyroid gland is performed in 77% to 92% of patients . The series that have assessed preoperative predictive factors are small, and although meta‐analyses are rigorously methodological, unfortunately they tend to be heterogeneous .…”

Section: Introductionmentioning

confidence: 99%

Evidence‐based management of the thyroid gland during a total laryngectomy

Gorphe¹,

Lakhdar

Tao³

et al. 2015

The Laryngoscope

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“…Other studies [8][9][10][11] recommend thyroidectomy during (pharyngo) laryngectomy in advanced hypopharyngeal tumors but also in laryngeal carcinoma cases with subglottic extension.…”

Section: Discussionmentioning

confidence: 99%

The Role of Thyroidectomy in Advanced Laryngeal and Pharyngolaryngeal Carcinoma

Dequanter

Shahla

Paulus

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Total thyroidectomy or hemithyroidectomy together with a total laryngectomy (TL) or pharyngo laryngectomy (TPL) for (pharyngo) laryngeal cancer often renders the patient hypothyroid and commits them to life-long thyroid hormone replacement. To determine the incidence of thyroid gland invasion (TG) in patients undergoing TL or TPL with total thyroidectomy (TThy) or lobectomy (HThy) for advanced laryngeal or hypo pharyngeal cancer and to assess predicative factors. Retrospective analysis of 35 patients from 2007 to 2010. Specimens were examined to determine the incidence of TG invasion and relevant predicative factors such as histological grade and subglottic extension. Pre-operative imaging was reviewed to assess for radiological evidence of TG invasion. TL and TThy was performed in 13 patients. TL and HThy was performed in four patients and TPL and TThy was performed in 18 patients. Surgery was performed for primary and recurrent cancer in 29 and six patients, respectively. Histological evidence of invasion of the TG was found in three patients. Relationship was found between TG invasion and subsite of primary carcinoma and the presence of subglottic extension. No relationship was found between TG invasion and patient's sex, stage of primary disease at surgery, degree of differentiation. In addition, no significant relationship was found between the presence of TG invasion and recurrent disease. Invasion of the TG in patients undergoing a TL or TPL is a rare event and limits the need for a TTHy in most cases.

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Role of thyroidectomy in advanced laryngeal and pharyngolaryngeal carcinoma

Abstract: Invasion of the TG in patients undergoing TL or TPL is a rare event and limits the need for TThy in most cases.

Cited by 39 publications

References 19 publications

Management of the thyroid gland during laryngectomy

Management of the thyroid gland during laryngectomy

Evidence‐based management of the thyroid gland during a total laryngectomy

The Role of Thyroidectomy in Advanced Laryngeal and Pharyngolaryngeal Carcinoma

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