Role of thyroid hormones in the effects of selenium on mood, behavior, and cognitive function

Sher, Leo

doi:10.1054/mehy.2001.1369

Cited by 44 publications

(30 citation statements)

References 25 publications

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“…The relationship between mood, behaviour and cognitive function with alterations in thyroid function, has resulted in researchers suggesting that the effects of selenium status on mood, may in part be due to the complex interaction with thyroid function [27] .…”

Section: Seleniummentioning

confidence: 99%

Effect of Micronutrient Supplementation on Mood in Nursing Home Residents

et al. 2008

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One third of older people in nursing and/or residential homes have significant symptoms of depression. In younger people, deficiencies in selenium, vitamin C and folate are associated with depression. This study examines the association between micronutrient status and mood before and after supplementation. The objective was to determine whether the administration of selenium, vitamin C and folate improved mood in frail elderly nursing home residents. Mood was assessed using the Hospital Anxiety and Depression rating scale (HAD), and Montgomery-Åsberg Depression Rating Scale (MADRS). Micronutrient supplementation was provided for 8 weeks in a double-blinded randomised controlled trial. Significant symptoms of depression (29%) and anxiety (24%) were found at baseline. 67% of patients had low serum concentrations of vitamin C, but no-one was below the reference range for selenium. Depression was significantly associated with selenium levels, but not with folate or vitamin C levels. No individual with a HAD depression score of ≧8, had selenium levels >1.2 µM. In those patients with higher HAD depression scores, there was a significant reduction in the score and a significant increase in serum selenium levels after 8 weeks of micronutrient supplementation. Placebo group scores were unchanged. This small study concluded that depression was associated with low levels of selenium in frail older individuals. Following 8 weeks of micronutrient supplementation, there was a significant increase in selenium levels and improved symptoms of depression occurred in a subgroup.

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Section: Seleniummentioning

confidence: 99%

Effect of Micronutrient Supplementation on Mood in Nursing Home Residents

et al. 2008

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“…Hypothyroidism during human perinatal development results in profound alterations of mental capacities, neurological functions and metabolic processes (Darbra et al, 2003;Dong et al, 2005). The possibility of cognitive dysfunction, even in minor degrees of thyroid failure, has been pointed by some authors on the basis of neuropsychiatric consequences of myxedema in humans (Sher, 2001;Baldini et al, 1997;Monzani et al, 1993;Haggerty et al, 1990). Several studies with hypothyroid patients usually reported cognitive impairments (Burmeister et al, 2001;Roberts & Ladenson, 2004;Zhu et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Effects of Thyroid Hormones on Memory and on Na+, K+-ATPase Activity in Rat Brain

Reis-Lunardelli¹,

Castro²,

Bavaresco³

et al. 2007

CNR

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Thyroid hormones (THs), including triiodothyronine (T3) and tetraiodothyronine (T4), are recognized as key metabolic hormones of the body. THs are essential for normal maturation and function of the mammalian central nervous system (CNS) and its deficiency, during a critical period of development, profoundly affects cognitive function. Sodium-potassium adenosine 5'-triphosphatase (Na(+), K(+)-ATPase) is a crucial enzyme responsible for the active transport of sodium and potassium ions in the CNS necessary to maintain the ionic gradient for neuronal excitability. Studies suggest that Na(+), K(+)-ATPase might play a role on memory formation. Moreover, THs were proposed to stimulate Na(+), K(+)-ATPase activity in the heart of some species. In this work we investigated the effect of a chronic administration of L-thyroxine (L-T4) or propylthiouracil (PTU), an antithyroid drug, on some behavioral paradigms: inhibitory avoidance task, open field task, plus maze and Y-maze, and on the activity of Na(+), K(+)-ATPase in the rat parietal cortex and hippocampus. By using treatments which have shown to induce alterations in THs levels similar to those found in hyperthyroid and hypothyroid patients, we aimed to understand the effect of an altered hyperthyroid and hypothyroid state on learning and memory and on the activity of Na(+), K(+)-ATPase. Our results showed that a hyper and hypothyroid state can alter animal behavior and they also might indicate an effect of THs on learning and memory.

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“…While depression is strongly associated with hypothyroidism, the exact mechanisms are not yet known [43-45]. Haggerty states that almost 100% of patients presenting with severe hypothyroidism, are found to have serious concurrent depression [37].…”

Section: Hypothyroidism Mood Disorders and Stressmentioning

confidence: 99%

“…This carrier protein appears reduced in the cerebrospinal fluid (CSF) of depressed patients, which prevents the transport of thyroid hormones to the brain [45,46,49]. Alterations in central nervous system (CNS) thyroid hormone levels have a major effect on the serotonergic, adrenergic and GABAergic systems.…”

Section: Hypothyroidism Mood Disorders and Stressmentioning

confidence: 99%

The biopsychosocial model and hypothyroidism

2005

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This paper comments on the role and emergence of the biopsychosocial model in modern medical literature and health care settings. The evolution of the biopsychosocial model and its close association with modern pain theory is also examined. This paper seeks to discuss the place of this model with respect to the management of hypothyroidism. This discussion represents a forerunner to a randomised control trial that will seek to investigate the effect of a biopsychosocial-based treatment regime on hypothyroidism.

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Role of thyroid hormones in the effects of selenium on mood, behavior, and cognitive function

Cited by 44 publications

References 25 publications

Effect of Micronutrient Supplementation on Mood in Nursing Home Residents

Effect of Micronutrient Supplementation on Mood in Nursing Home Residents

Effects of Thyroid Hormones on Memory and on Na+, K+-ATPase Activity in Rat Brain

The biopsychosocial model and hypothyroidism

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