Role of the σ receptor in the inhibition of [³H]‐noradrenaline uptake in brain synaptosomes and adrenal chromaffin cells

Neurosteroids in depression: a review

“…As has already been mentioned, enhancement of noradrenaline (Delgado and Moreno 2000) and serotonin (Delgado 2000) neurotransmission is considered to have an antidepressant effect. In vitro experiments suggest that sigma ligands inhibit noradrenaline presynaptic re-uptake in brain synaptosomes (Kinouchi et al 1989;Rogers and Lemaire 1991) and increase noradrenaline release (Kinouchi et al 1989). Furthermore, treatment with DHEAS increases the number of NMDA receptors (Wen et al 2001) and potentiates NMDA-evoked noradrenaline release via sigma 1 receptors (Monnet et al 1995).…”

The EphA4 Receptor Regulates Neuronal Morphology through SPAR-Mediated Inactivation of Rap GTPases

“…The preparation of synaptosomal fractions was adapted from Rogers and Lemaire (1991) and is described in more detail by Bourgin et al (2007).…”

Sigma-1 Receptor Chaperones and Diseases

“…The sigma-1 receptor exists not only in the CNS but also in the peripheral organs [21] including the liver, adrenal gland, pancreas, and spleen wherein the receptor has been implicated in the hepatocyte survival [56], norepinephrine uptake [57], insulin secretion [58], and immune response [59] respectively. One cannot help but asking: Does the sigma-1 receptor act the same as a ligand-operated receptor chaperone in all those organs just as shown in the model system using CHO cells [21]?…”