Role of the Value Circuit in Addiction and Addiction Treatment

Konova, Anna B.; Goldstein, Rita Z.

doi:10.1002/9781118472415.ch5

Cited by 4 publications

(1 citation statement)

References 129 publications

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“…Over the past two decades, neuroimaging has contributed important insight into the structural and functional brain alterations linked with drug abuse in general [ 1 – 3 ] and nicotine addiction in particular [ 4 – 6 ]. For example, such studies have revealed that nicotine administration alters functional brain activity, inducing enhanced activity in some regions involved with attention and cognition (e.g., thalamus, lateral frontoparietal cortices, anterior cingulate cortex [ACC]) yet reducing activity in other regions involved with task-irrelevant mental operations (e.g., mind wandering; ventromedial prefrontal cortex, posterior cingulate cortex, parahippocampus) [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations

et al. 2016

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BackgroundWhereas acute nicotine administration alters brain function which may, in turn, contribute to enhanced attention and performance, chronic cigarette smoking is linked with regional brain atrophy and poorer cognition. However, results from structural magnetic resonance imaging (MRI) studies comparing smokers versus nonsmokers have been inconsistent and measures of gray matter possess limited ability to inform functional relations or behavioral implications. The purpose of this study was to address these interpretational challenges through meta-analytic techniques in the service of clarifying the impact of chronic smoking on gray matter integrity and more fully contextualizing such structural alterations.MethodsWe first conducted a coordinate-based meta-analysis of structural MRI studies to identify consistent structural alterations associated with chronic smoking. Subsequently, we conducted two additional meta-analytic assessments to enhance insight into potential functional and behavioral relations. Specifically, we performed a multimodal meta-analytic assessment to test the structural–functional hypothesis that smoking-related structural alterations overlapped those same regions showing acute nicotinic drug-induced functional modulations. Finally, we employed database driven tools to identify pairs of structurally impacted regions that were also functionally related via meta-analytic connectivity modeling, and then delineated behavioral phenomena associated with such functional interactions via behavioral decoding.ResultsAcross studies, smoking was associated with convergent structural decreases in the left insula, right cerebellum, parahippocampus, multiple prefrontal cortex (PFC) regions, and the thalamus. Indicating a structural–functional relation, we observed that smoking-related gray matter decreases overlapped with the acute functional effects of nicotinic agonist administration in the left insula, ventromedial PFC, and mediodorsal thalamus. Suggesting structural-behavioral implications, we observed that the left insula’s task-based, functional interactions with multiple other structurally impacted regions were linked with pain perception, the right cerebellum’s interactions with other regions were associated with overt body movements, interactions between the parahippocampus and thalamus were linked with memory processes, and interactions between medial PFC regions were associated with face processing.ConclusionsCollectively, these findings emphasize brain regions (e.g., ventromedial PFC, insula, thalamus) critically linked with cigarette smoking, suggest neuroimaging paradigms warranting additional consideration among smokers (e.g., pain processing), and highlight regions in need of further elucidation in addiction (e.g., cerebellum).Electronic supplementary materialThe online version of this article (doi:10.1186/s12993-016-0100-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations

et al. 2016

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Recent Opioid Use Impedes Range Adaptation in Reinforcement Learning in Human Addiction

Gueguen,

Anlló,

Bonagura

et al. 2024

Biological Psychiatry

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Common and Distinct Drug Cue Reactivity Patterns Associated with Cocaine and Heroin: An fMRI Meta-Analysis

Dejoie,

Senia,

Konova

et al. 2023

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Substance use and substance use disorders (SUDs) represent ongoing major public health crises. Specifically, the use of illicit substances such as cocaine and heroin are responsible for over 50,000 drug related deaths annually. Our study used a comparative meta-analysis procedure to contrast activation patterns that may help explain the behavioral differences observed. PubMed and Google Scholar were searched for studies with within-subject whole brain analyses comparing drug to neutral cues for users of cocaine and heroin. A total of 18 studies were included, 9 in each subgroup. Voxel-based meta-analyses were performed using seed-based d mapping with permuted subject images (SDM-PSI) for subgroup mean analyses and a contrast meta-regression comparing the two substances. Mean analysis results indicated that users of heroin showed more widespread activation in the nucleus accumbens, right inferior and left middle temporal gyrus, the right thalamus, and the right cerebellum while cocaine use was associated with recruitment of lateral prefrontal cortex. Direct comparison of cue reactivity studies in heroin relative to cocaine users revealed greater activation in dopaminergic targets for users of heroin compared to users of cocaine. Differential activation patterns between substances may underlie behavioral differences observed across users of illicit substances, including seeking mood numbing effects in users of heroin. More consistent research methodology is needed to provide adequate studies for stringent meta-analyses examining common and distinct neural activation patterns across substances.

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Role of the Value Circuit in Addiction and Addiction Treatment

Cited by 4 publications

References 129 publications

Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations

Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations

Recent Opioid Use Impedes Range Adaptation in Reinforcement Learning in Human Addiction

Common and Distinct Drug Cue Reactivity Patterns Associated with Cocaine and Heroin: An fMRI Meta-Analysis

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