Role of the tumor necrosis factor family member LIGHT in the pathogenesis of atopic dermatitis

Seifeldin, Neveen S.; Sayed, Shereen Bendary El; Asaad, Marwa K.; Aly, Alaa Ahmed

doi:10.1111/ijd.12851

Cited by 1 publication

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“…TNFSF14, chiefly synthesized by CD4 + and CD8 + T cells, has garnered attention in the context of AD ( 33 ). Compared to healthy counterparts, AD patients exhibit markedly elevated serum levels of TNFSF14, positioning it as a potential biomarker for assessing disease severity ( 34 ). The role of TNFSF14 in AD is multifaceted, with implications for keratinocyte stimulation.…”

Section: Discussionmentioning

confidence: 99%

Exploring causal correlations between circulating cytokines and atopic dermatitis: a bidirectional two-sample Mendelian randomization study

Xuan,

Chen,

Zhou

et al. 2024

Front. Immunol.

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ObjectivesNumerous observational studies have reported associations between circulating cytokines and atopic dermatitis (AD); however, the causal relationships between them remain unclear. To explore the causal correlations and direction of causal effects between AD and levels of 91 circulating cytokines.MethodsTwo-sample Mendelian randomization (MR) analyses were conducted to examine the causal relationships between 91 circulating cytokines and AD using summary statistics from genome-wide association studies (GWAS). Reverse MR analyses were performed to investigate reverse causation. Pleiotropy and heterogeneity tests were conducted to assess the robustness of the findings. Additional transcriptome database and clinical peripheral blood mononuclear cells (PBMCs) samples were utilized to validate the results of MR analyses.ResultsLevels of interleukin (IL)-13, IL-18 Receptor 1, Tumor necrosis factor ligand superfamily member 14 (TNFSF14), TNF-related activation-induced cytokine (TRANCE), C-X-C motif chemokine (CXCL)11, IL-33, TNF-beta and CD5 were suggestively associated with the risk of AD (odds ratio, OR: 1.202, 95% CI: 1.018–1.422, p = 0.030; OR: 1.029, 95% CI: 1.029–1.157, p = 0.004; OR: 1.159, 95% CI: 1.018–1.320, p = 0.026; OR: 1.111, 95% CI: 1.016–1.214, p = 0.020; OR: 0.878, 95% CI: 0.783–0.984, p = 0.025; OR: 0.809, 95% CI: 0.661–0.991, p = 0.041; OR: 0.945, 95% CI: 0.896–0.997, p = 0.038; OR: 0.764, 95% CI: 0.652–0.895, p = 8.26e-04). In addition, levels of cytokines including Axin-1, CXCL5, CXCL10, Oncostatin-M (OSM), Sulfotransferase 1A1 (SULT1A1) and TNFSF14 were suggested to be consequences of AD (Beta: -0.080, p = 0.016; Beta: -0.062, p = 0.036; Beta: -0.066, p = 0.049; Beta: -0.073, p = 0.013; Beta: -0.089, p = 0.008; Beta: -0.079, p = 0.031). IL-13, IL-18R1, TNFSF14, and TRANCE were upregulated in both lesional skin biopsies and PBMCs from AD patients.ConclusionThe study indicates that several cytokines, including IL-13, IL-18R1, TNFSF14, TRANCE, CXCL11, IL-33, TNF-beta, and CD5, are upstream of AD development, whereas a few circulating cytokines are potentially downstream in the development of AD.

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Section: Discussionmentioning

confidence: 99%

Exploring causal correlations between circulating cytokines and atopic dermatitis: a bidirectional two-sample Mendelian randomization study

Xuan,

Chen,

Zhou

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Role of the tumor necrosis factor family member LIGHT in the pathogenesis of atopic dermatitis

Abstract: LIGHT may play an important role in the pathogenesis of AD. This may presumably have possible future implications on the treatment of this chronic disease.

Cited by 1 publication

References 41 publications

Exploring causal correlations between circulating cytokines and atopic dermatitis: a bidirectional two-sample Mendelian randomization study

Exploring causal correlations between circulating cytokines and atopic dermatitis: a bidirectional two-sample Mendelian randomization study

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