Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction

Yerna, Xavier; Schakman, Olivier; Ratbi, Ikram; Kreis, Anna; Lepannetier, Sophie; Clippele, Marie de; Achouri, Younès; Tajeddine, Nicolas; Tissir, Fadel; Gualdani, Roberta; Gailly, Philippe

doi:10.3390/ijms21051712

Cited by 15 publications

(12 citation statements)

References 60 publications

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“…This indicates that TRPC1 plays a role in synaptic plasticity and spatial working memory processes [ 223 ]. TRPC1 was also implicated in altering the extinction of spatial reference memory [ 224 ]. Loss of TRPC1, TRPC4, and TRPC5 impacts plasticity by decreasing basal-evoked secretion, reducing the pool size of available vesicles, and accelerating synaptic depression during high-frequency stimulation.…”

Section: Physiological and Pathological Functions Of Trpcs Revealementioning

confidence: 99%

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now

Chen

Sooch

Demaree

et al. 2020

Cells

106

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Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7). TRPCs exhibit the highest protein sequence similarity to the Drosophila melanogaster TRP channels. Similar to Drosophila TRPs, TRPCs are localized to the plasma membrane and are activated in a G-protein-coupled receptor-phospholipase C-dependent manner. TRPCs may also be stimulated in a store-operated manner, via receptor tyrosine kinases, or by lysophospholipids, hypoosmotic solutions, and mechanical stimuli. Activated TRPCs allow the influx of Ca2+ and monovalent alkali cations into the cytosol of cells, leading to cell depolarization and rising intracellular Ca2+ concentration. TRPCs are involved in the continually growing number of cell functions. Furthermore, mutations in the TRPC6 gene are associated with hereditary diseases, such as focal segmental glomerulosclerosis. The most important recent breakthrough in TRPC research was the solving of cryo-EM structures of TRPC3, TRPC4, TRPC5, and TRPC6. These structural data shed light on the molecular mechanisms underlying TRPCs’ functional properties and propelled the development of new modulators of the channels. This review provides a historical overview of the major advances in the TRPC field focusing on the role of gene knockouts and pharmacological tools.

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Section: Physiological and Pathological Functions Of Trpcs Revealementioning

confidence: 99%

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now

Chen

Sooch

Demaree

et al. 2020

Cells

106

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“…Studies have shown that type I mGluR-mediated synaptic plasticity occurs via the β -arrestin signaling pathway [ 123 ]. The TRPC1 channel plays a critical role in the process of mGluR5-regulated plasticity [ 124 ].…”

Section: Changes In Hippocampal Plasticity In Depressionmentioning

confidence: 99%

Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes

Yao

Zhao

et al. 2020

Neural Plasticity

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Depression is a common neurological disease that seriously affects human health. There are many hypotheses about the pathogenesis of depression, and the most widely recognized and applied is the monoamine hypothesis. However, no hypothesis can fully explain the pathogenesis of depression. At present, the brain-derived neurotrophic factor (BDNF) and neurogenesis hypotheses have highlighted the important role of plasticity in depression. The plasticity of neurons and glial cells plays a vital role in the transmission and integration of signals in the central nervous system. Plasticity is the adaptive change in the nervous system in response to changes in external signals. The hippocampus is an important anatomical area associated with depression. Studies have shown that some antidepressants can treat depression by changing the plasticity of the hippocampus. Furthermore, caloric restriction has also been shown to affect antidepressant and hippocampal plasticity changes. In this review, we summarize the latest research, focusing on changes in the plasticity of hippocampal neurons and glial cells in depression and the role of BDNF in the changes in hippocampal plasticity in depression, as well as caloric restriction and mitochondrial plasticity. This review may contribute to the development of antidepressant drugs and elucidating the mechanism of depression.

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“…Thereafter, using T-maze, radial maze and Morris water maze, Trpc1 −/− as well as Trpc1/Trpc4/Trpc5triple-knockout (Trpc1/4/5 −/− ) mice were shown to present deficits in spatial working memory but not in spatial reference memory [16,57]. They also exhibited deficiencies in spatial memory extinction and in relearning tasks [16,58]. In contrast, compared to age-match controls, Trpc3 −/− mice performed better in contextual fear conditioning test [59].…”

Section: Trpc Channels Modulate Memory: Lessons From Knockout Animalsmentioning

confidence: 99%

How TRPC Channels Modulate Hippocampal Function

Gualdani

Gailly

2020

IJMS

Self Cite

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Transient receptor potential canonical (TRPC) proteins constitute a group of receptor-operated calcium-permeable nonselective cationic membrane channels of the TRP superfamily. They are largely expressed in the hippocampus and are able to modulate neuronal functions. Accordingly, they have been involved in different hippocampal functions such as learning processes and different types of memories, as well as hippocampal dysfunctions such as seizures. This review covers the mechanisms of activation of these channels, how these channels can modulate neuronal excitability, in particular the after-burst hyperpolarization, and in the persistent activity, how they control synaptic plasticity including pre- and postsynaptic processes and how they can interfere with cell survival and neurogenesis.

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Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction

Cited by 15 publications

References 60 publications

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now

Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes

How TRPC Channels Modulate Hippocampal Function

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