Role of the transforming growth factor‐β signaling pathway in the pathogenesis of colorectal cancer

Soleimani, Atena; Pashirzad, Mehran; Rezayi, Majid; Ferns, Gordon A.; Hassanian, Seyed Mahdi

doi:10.1002/jcb.28331

Cited by 38 publications

(31 citation statements)

References 93 publications

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“…TGF‐β1 is essential for the induction of EMT and regulating autophagy‐induced EMT. In conclusion, TGF‐β1‐induced EMT is inhibited by miR‐16 in NSCLC cells by activation of autophagy through regulating ATG3 …”

Section: Tumor Suppressor Micrornasmentioning

confidence: 87%

Tumor suppressor microRNAs in lung cancer: An insight to signaling pathways and drug resistance

Asghariazar

Sakhinia

Mansoori

et al. 2019

J of Cellular Biochemistry

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Lung cancer (LC) is the second common cancer for both women and men all over the world. Unfortunately, the number of LC deaths is increasing rapidly each year so early diagnosis of LC can be lifesaving. MicroRNAs are involved in multiple processes, such as cell differentiation, transcription, inflammation, proliferation, cell signaling, and apoptosis. In LC, microRNAs function as tumor suppressors (TS) or oncogenes depending on the targets. Changes in microRNAs expression level are related to tumor initiation, progression, and metastasis. MicroRNAs can regulate gene expression and thus affect the activity status of different signaling pathways including AKT, JAK-STAT, MAPK, TGF-β, WNT, and ERK signaling pathways. Positive or negative effects on drug resistance of LC are directly affected by microRNAs and their target genes. MicroRNAs can be beneficial in combination therapy with other drugs and chemotherapeutic agents for LC. K E Y W O R D S drug resistance, lung cancer, microRNA, signaling pathways, tumor suppressor How to cite this article: Asghariazar V, Sakhinia E, Mansoori B, Mohammadi A, Baradaran B. Tumor suppressor microRNAs in lung cancer: An insight to signaling pathways and drug resistance.

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Section: Tumor Suppressor Micrornasmentioning

confidence: 87%

Tumor suppressor microRNAs in lung cancer: An insight to signaling pathways and drug resistance

Asghariazar

Sakhinia

Mansoori

et al. 2019

J of Cellular Biochemistry

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“…Cancer progression is caused by several changes in oncogenes and tumor-suppressor genes during several years [42]. Numerous studies have indicated a main role for miRNAs in the cancer pathogenesis [42]. miRNAs can affect cancer progression through regulation of cell growth and apoptosis [42].…”

Section: Microrna and Cancer Developmentmentioning

confidence: 99%

“…Numerous studies have indicated a main role for miRNAs in the cancer pathogenesis [42]. miRNAs can affect cancer progression through regulation of cell growth and apoptosis [42]. The miRs are used as biomarkers for assessing cancer prognosis and drug efficacy [42].…”

Section: Microrna and Cancer Developmentmentioning

confidence: 99%

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Flaming the fight against cancer cells: the role of microRNA-93

et al. 2020

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There have been attempts to develop novel anti-tumor drugs in cancer therapy. Although satisfying results have been observed at a consequence of application of chemotherapeutic agents, the cancer cells are capable of making resistance into these agents. This has forced scientists into genetic manipulation as genetic alterations are responsible for generation of a high number of cancer cells. MicroRNAs (miRs) are endogenous, short non-coding RNAs that affect target genes at the post-transcriptional level. Increasing evidence reveals the potential role of miRs in regulation of biological processes including angiogenesis, metabolism, cell proliferation, cell division, and cell differentiation. Abnormal expression of miRs is associated with development of a number of pathologic events, particularly cancer. MiR-93 plays a significant role in both physiological and pathological mechanisms. At the present review, we show how this miR dually affects the proliferation and invasion of cancer cells. Besides, we elucidate the oncogenesis or oncosuppressor function of miR-93.

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“…So, there is a need for developing new anticancer drugs to be used with conventional and newly introduced anticancer drugs for targeting multiple signaling pathways and making a reduction in the viability of cancer cells. It seems that plant‐derived chemicals with high antitumor activity are of interest due to their minimal side effects and multitargeting (Ashrafizadeh, Ahmadi, Farkhondeh, & Samarghandian, ; Ashrafizadeh et al, ; Ashrafizadeh et al, ; Khoshakhlagh et al, ; Soleimani et al, ; Soleimani et al, ; Tavakol et al, ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs as novel targets of sulforaphane in cancer therapy: The beginning of a new tale?

Rafiei

Ashrafizadeh

Ahmadi

2020

Phytotherapy Research

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Effective management and treatment of cancer depend on developing novel antitumor drugs with the capability of targeting various molecular pathways. Identification and subsequent targeting of these pathways are of importance in cancer therapy. MicroRNAs (miRNAs) are small noncoding RNA molecules responsible for post‐transcriptional regulation of genes. Notably, miRNAs participate in a number of biological processes such as proliferation, apoptosis, differentiation, and cell cycle regulation. So, any impairment in the expression and function of miRNAs is associated with development of disorders, particularly cancer. Naturally occurring nutraceutical compounds have attracted much attention due to their great antitumor activity. Among them, sulforaphane isolated from Brassica oleracea (broccoli) is of interest due to its therapeutic and biological activities such as antidiabetic, antioxidant, anti‐inflammatory, hepatoprotection, and cardiprotection. Sulforaphane has demonstrated great antitumor activity and is able to significantly inhibit proliferation, viability, migration, malignancy, and epithelial‐to‐mesenchymal transition of cancer cells. These antitumor effects have widely been investigated, and it appears that there is a need for a precise review to demonstrate the molecular pathway that sulforaphane follows to exert its antitumor activity. At the present review, we focus on the modulatory impact of sulforaphane on miRNAs and exhibit that how various miRNAs in different cancers are regulated by sulforaphane.

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Role of the transforming growth factor‐β signaling pathway in the pathogenesis of colorectal cancer

Cited by 38 publications

References 93 publications

Tumor suppressor microRNAs in lung cancer: An insight to signaling pathways and drug resistance

Tumor suppressor microRNAs in lung cancer: An insight to signaling pathways and drug resistance

Flaming the fight against cancer cells: the role of microRNA-93

MicroRNAs as novel targets of sulforaphane in cancer therapy: The beginning of a new tale?

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