Role of the T2Dx magnetic resonance assay in patients with suspected bloodstream infection: a single-centre real-world experience

Quirino, Angela; Scaglione, Vincenzo; Marascio, Nadia; Mazzitelli, Maria; Garofalo, Eugenio; Divenuto, Francesca; Serapide, Francesca; Bruni, Andrea; Lionello, Rosaria; Pavia, Grazia; Costa, Cristina; Giancotti, Aida; Peronace, Cinzia; Longhini, Federico; Russo, Alessandro; Liberto, Maria Carla; Matera, Giovanni; Torti, Carlo; Trecarichi, Enrico Maria

doi:10.1186/s12879-022-07096-w

Cited by 8 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the time to antifungal administration was considerably shorter in the T2MR group than in the BC group (4 hours vs. 37) [ 122 ]. Other authors report similar results [ 123 , 128 - 130 ].…”

Section: What Is the Performance Of T2 Magnetic Resonance (T2mr) Cand...supporting

confidence: 79%

See 1 more Smart Citation

Unresolved issues in the diagnosis of catheter related candidemia: A position paper

Soriano-Martín,

Muñoz,

García-Rodríguez

et al. 2023

Rev Esp Quimioter

View full text Add to dashboard Cite

The incidence and recent trends of candidemia and the contribution of the COVID-19 pandemic to its evolution are not well documented. The catheter is a major focus of Candida spp. infections, but the methods used to confirm the origin of candidemia are still based on the data generated for bacterial infection. The presence of Candida spp. on the tip of a removed catheter is the gold standard for confirmation but it is not always possible to remove it. Conservative methods, without catheter removal, have not been specifically studied for microorganisms whose times of growth are different from those of bacteria and therefore these results are not applicable to candidemia. The different Candida species do not have a particular tropism for catheter colonization and fungal biomarkers have not yet been able to contribute to the determination of the origin of candidemia. Techniques such Candida T2 Magnetic Resonance (T2MR) has not yet been applied for this purpose. Finally, there is not yet a consensus of how to proceed when Candida spp. is isolated from an extracted catheter and blood cultures obtained from simultaneous peripheral veins are negative. In this lack of firm data, a group of experts has formulated a series of questions trying to answer them based on the literature, indicating the current deficiencies and offering their own opinion. All authors agree with the conclusions of the manuscript and offer it as a position and discussion paper.

show abstract

Section: What Is the Performance Of T2 Magnetic Resonance (T2mr) Cand...supporting

confidence: 79%

“…In addition, the detection limit is very low, 1-3 cfu/ml whole blood [120]. This method has a high sensitivity (91.1-100%) and specificity (97.8%-98.9%) for those species [121][122][123][124].…”

Section: Resonance (T2mr) Candidemia Detection? Are There Studies In ...mentioning

confidence: 94%

Unresolved issues in the diagnosis of catheter related candidemia: A position paper

Soriano-Martín,

Muñoz,

García-Rodríguez

et al. 2023

Rev Esp Quimioter

View full text Add to dashboard Cite

show abstract

“…We observed a low number of antifungal initiation based on a positive T2Candida alone, consistent with the high specificity observed and with a previous report of lower inappropriate antimicrobial use when T2Candida and T2Bacteria were used to diagnose bloodstream infections. 18 Due to the low number of confirmed cases of IC, we did not formally report sensitivity, but it was evident that not all IC cases resulted in a positive T2Candida result. Previous studies have indicated higher test sensitivity when compared with proven candidaemia (71%–91%), 6 , 12 highlighting the importance of defining test characteristics in different clinical settings and the variability in gold standard definitions used for Candida infections.…”

Section: Discussionmentioning

confidence: 99%

T2Candida assay: diagnostic performance and impact on antifungal prescribing

Jesus

Houston

Schutte

et al. 2023

JAC-Antimicrobial Resistance

View full text Add to dashboard Cite

Objectives To assess the performance of T2Candida for the diagnosis of invasive candidiasis (IC) against gold standards of candidaemia or consensus IC definitions, and to evaluate the impact of T2Candida on antifungal drug prescribing. Methods A retrospective review was undertaken of all T2Candida (T2MR technology, T2 Biosystems) performed from October 2020 to February 2022. T2Candida performance was evaluated against confirmed candidaemia or against proven/probable IC within 48 hours of T2Candida, and its impact on antifungal drug prescriptions. Results T2Candida was performed in 61 patients, with 6 (9.8%) positive results. Diagnostic performance of T2Candida against candidaemia had a specificity of 85.7% and negative predictive value (NPV) of 96.8%. When comparing T2Candida results with consensus definitions of IC, the specificity and NPV of T2Candida was respectively 90% (54/60) and 98.2% (54/55) for proven IC, and 91.4% (53/58) and 96.4% (53/55) for proven/probable IC. Antifungals were initiated in three of six patients (50%) with a positive T2Candida result. Thirty-three patients were receiving empirical antifungals at the time of T2Candida testing, and a negative result prompted cessation of antifungals in 11 (33%) patients, compared with 6 (25%) antifungal prescriptions stopped following negative beta-d-glucan (BDG) testing in a control population (n = 24). Conclusions T2Candida shows high specificity and NPV compared with evidence of Candida bloodstream infection or consensus definitions for invasive Candida infection, and may play an adjunctive role as a stewardship tool to limit unnecessary antifungal prescriptions.

show abstract

“…Indeed, the application of advanced mycological screening for prompt diagnosis and dedicated treatments, based on drug susceptibility testing when available, is recommended for improving survival after LT [37].…”

Section: Discussionmentioning

confidence: 99%

Fungal Infections and Colonization after Bilateral Lung Transplant: A Six-Year Single-Center Experience

Boscolo,

Cattelan,

Marinello

et al. 2024

JoF

Self Cite

View full text Add to dashboard Cite

Fungal infections (FIs) are one of the leading causes of morbidity and mortality within the first year of lung transplant (LT) in LT recipients (LTRs). Their prompt identification and treatment are crucial for a favorable LTR outcome. The objectives of our study were to assess (i) the FI incidence and colonization during the first year after a bilateral LT, (ii) the risk factors associated with FI and colonization, and (iii) the differences in fungal incidence according to the different prophylactic strategies. All bilateral LTRs admitted to the intensive care unit of Padua University Hospital were retrospectively screened, excluding patients <18 years of age, those who had been re-transplanted, and those who had received ventilation and/or extracorporeal membrane oxygenation before LT. Overall, 157 patients were included. A total of 13 (8%) patients developed FI, and 36 (23%) developed colonization, which was mostly due to Aspergillus spp. We did not identify independent risk factors for FI. Groups of patients receiving different prophylactic strategies reported a similar incidence of both FI and colonization. The incidence of FI and fungal colonization was 8% and 23%, respectively, with no differences between different antifungal prophylaxes or identified predisposing factors. Further studies with larger numbers are needed to confirm our results.

show abstract

Role of the T2Dx magnetic resonance assay in patients with suspected bloodstream infection: a single-centre real-world experience

Cited by 8 publications

References 31 publications

Unresolved issues in the diagnosis of catheter related candidemia: A position paper

Unresolved issues in the diagnosis of catheter related candidemia: A position paper

T2Candida assay: diagnostic performance and impact on antifungal prescribing

Fungal Infections and Colonization after Bilateral Lung Transplant: A Six-Year Single-Center Experience

Contact Info

Product

Resources

About