Role of the T cell receptor in idiopathic thrombocytopenic purpura (ITP)

Abstract

Hedlund-Treutiger I, Wahlström J, Elinder G. Role of the T cell receptor in idiopathic thrombocytopenic purpura (ITP). Acta Paediatr 1998; Suppl 424: 46-50. Stockholm. ISSN 0803-5253.During the past few decades a number of studies has described T cell defects and attempted to elucidate their role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP). Some studies implicate T cells as potential initiators of autoantibody production in ITP. However, only a few of these have studied the role that the T cell receptor may play in the pathogenesis of ITP. In a variety of autoimmune syndromes interest has focused on the aand b-chains of the T cell receptor. Deviations from the normal T cell receptor gene usage have been reported in rheumatoid arthritis, systemic lupus erythaematosus and multiple sclerosis. Usually, these studies have shown a restricted heterogeneity of T cell receptor variable gene usage. The studies on the T cell receptor in ITP have included a limited number of patients, which makes it difficult to evaluate the significance of the role that the T cell receptor may play in the pathogenesis of ITP. Further studies are warranted. ٖ Idiopathic thrombocytopenic purpura, T cell clones, T cell receptor

Favorable Response of Chronic Refractory Immune Thrombocytopenic Purpura to Mesenchymal Stem Cells

“…Chronic ITP is an autoimmune disorder in which activated Th cells and different Th-cell cytokines might play an important role [3][4][5][6][7][8][9][10][11][12][13][14][15]. So, T-cells depletion might be a fundamental condition for a positive outcome of transplantation in ITP, similar to that observed in other autoimmune diseases submitted to autologous transplantation, but in different reports its success has been variable [31][32][33][34][35].…”

“…Patients with chronic refractory ITP have the highest risk of death and disease-related or therapy-related complications [1,2]. Like in other autoimmune diseases, autoantibody production by B cells in ITP needs the help of T cells, as evidenced by its association with both T cell activation and T-B cognate interaction [3][4][5][6]. Almost all of these autoantigen-specific T cells are CD4…”

The feature of clonal expansion of TCR Vβ repertoire, thymic recent output function and TCRζ chain expression in patients with immune thrombocytopenic purpura

“…, 2000; Hedlund‐Treutiger et al. , 2004; Hedlund‐Treutiger, Wahlstrom & Elinder, 1998; Li et al ., 2005). Recently, it has been used to understand the underlying immune mechanism of several autoimmune diseases such as rheumatoid arthritis (Kato et al.…”

“…, 2005). Skewing expression and clonal expansion of TCR Vβ repertoire with frequent use of Vβ3, 6, 10, 13 and 14 were also observed in ITP (Hedlund‐Treutiger, Wahlstrom & Elinder, 1998; Hedlund‐Treutiger et al. , 2004), and the abnormalities were reverted in responders after treatment with rituximab (Stasi et al.…”

Characteristics of immune thrombocytopenic purpura: a guide for clinical practice

“…Some studies implicate T-cells as another potential initiator of autoantibody production in ITP. However, only a few studies have evaluated the role of the T-cell receptor, and its significance in the pathogenesis of ITP is difficult to determine (16).…”