Role of the supplementary motor area in motor deficit following medial frontal lobe surgery

Krainik, Alexandre; Lehericy, Stéphane; Duffau, Hugues; Vlaicu, M.; Poupon, Fabrice; Laurent, Césari; Cornu, Philippe; Clemenceau, Stéphane; Sahel, M.; Valéry, Charles-Ambroise; Boch, Anne‐Laure; Mangin, Jean François; Bihan, Denis Le; Marsault, C.

doi:10.1212/wnl.57.5.871

Cited by 181 publications

(100 citation statements)

References 26 publications

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“…Lesion reconstruction in the MRI imaging in the present case has pointed to disconnection of the right SMA and right BG, with preservation of the other premotor-subcortical loops. This finding is consistent with previous lesion and functional studies; Krainik et al (2001) discovered that in patients having undergone resection of the medial frontal lobe, the motor deficit occurs when the SMA is resected. The same result has been observed in a case of CVA involving the SMA (Marsden, 1989).…”

Section: Discussionsupporting

confidence: 92%

“…Akinesia recovered in two weeks. The regressive nature of the symptoms with an excellent motor outcome has been mentioned as a hallmark of SMA syndrome and SMA-basal ganglia disconnection (Kim, 2001;Kasasbeh et al, 2012;Krainik et al, 2001). Although the mechanism of rapid resolution of the symptoms is not fully understood, recruitment of the contralateral SMA and a preserved ipsilateral premotor area are considered to play key roles in this recovery (Bannur & Rajshekhar, 2000).…”

Section: Discussionmentioning

confidence: 99%

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Posterior SMA Syndrome following subcortical stroke: Contralateral akinesia reversed by visual feedback

et al. 2013

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Background: The supplementary motor area (SMA) plays a key role in motor programming and production and is involved in internally-cued movements. In neurological populations, SMA syndrome following a lesion to the "SMA proper" is characterized by transient impairment of voluntary movements and motor sequences. This syndrome is assumed to follow on from an interruption of the motor corticosubcortical loop, and some case reports indicate that such a syndrome could occur after a brain lesion isolating the SMA from subcortical structures. Aim: To characterize the pattern of motor impairments in a patient whose stroke disconnects the SMA from the subcortical motor loop. Method: A patient developed a moderate transient left hemiparesis following a subcortical stroke in the right anterior cerebral artery area, which disconnected the SMA from basal ganglia. Eight days after the stroke, when the hemiparesis had regressed, the patient presented a specific SMA motor disorder of the left hand which manifested as an akinesia and was exacerbated when his visual attention was not directed towards his hand. We assessed finger tapping with left and right hands, eyes closed and open, in the left and right hemispace. We indexed movement speed as the number of taps filmed over 5-s periods.Results: Left motor weakness (grasping strength of right hand: 49 kg and left hand: 41 kg) was resolved in a week. Ideomotor and ideational gestures and motor sequences were preserved. On the tapping task, left-hand tapping was slower than right-hand tapping. Critically, visual feedback improved tapping speed for the left, but not for the right, hand. The hemispace of the task execution had no effect on tapping performance. Conclusion: Our results suggest that SMA-basal ganglia disconnection decreases contralateral movement initiation and maintenance and this effect is partly compensated by visual cues.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Posterior SMA Syndrome following subcortical stroke: Contralateral akinesia reversed by visual feedback

et al. 2013

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“…SMA-proper is therefore activated in conjunction with overt articulation and movement of the lips and hands (78). In accord, clinical data reveal that lesions of the SMA-proper produce language and motor impairments (87,88), and transcranial magnetic stimulation confirms enhanced hand motor-evoked potentials to infant cry in women (89). Moreover, in contrast to the pre-SMA, the SMA-proper is activated by external triggers (83) and is involved with sequential processes (60).…”

Section: Resultsmentioning

confidence: 87%

Neurobiology of culturally common maternal responses to infant cry

Bornstein

Putnick

Rigo

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

147

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This report coordinates assessments of five types of behavioral responses in new mothers to their own infants' cries with neurobiological responses in new mothers to their own infants' cries and in experienced mothers and inexperienced nonmothers to infant cries and other emotional and control sounds. We found that 684 new primipara mothers in 11 countries (Argentina, Belgium, Brazil, Cameroon, France, Kenya, Israel, Italy, Japan, South Korea, and the United States) preferentially responded to their infants' vocalizing distress by picking up and holding and by talking to their infants, as opposed to displaying affection, distracting, or nurturing. Complementary functional magnetic resonance imaging (fMRI) analyses of brain responses to their own infants' cries in 43 new primipara US mothers revealed enhanced activity in concordant brain territories linked to the intention to move and to speak, to process auditory stimulation, and to caregive [supplementary motor area (SMA), inferior frontal regions, superior temporal regions, midbrain, and striatum]. Further, fMRI brain responses to infant cries in 50 Chinese and Italian mothers replicated, extended, and, through parcellation, refined the results. Brains of inexperienced nonmothers activated differently. Culturally common responses to own infant cry coupled with corresponding fMRI findings to own infant and to generic infant cries identified specific, common, and automatic caregiving reactions in mothers to infant vocal expressions of distress and point to their putative neurobiological bases. Candidate behaviors embedded in the nervous systems of human caregivers lie at the intersection of evolutionary biology and developmental cultural psychology.

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“…Thus patients with SMA lesions show an increase in reaction time on a sequential digit task but not much impairment in the production of the correct sequence (Halsband et al 1993). To the extent that mild deficits of sequence production do occur, these are confined to the limb-movement domain and recover quickly (Bleasel et al 1996;Chassoux et al 1999;Hanlon et al 1995;Krainik et al 2001;Laplane et al 1977;Rostomily et al 1991;Zentner et al 1996; see also review by Goldberg 1985).…”

Section: Rank Signals Are Widespread and Uniform In Frontal Cortexmentioning

confidence: 99%

Rank Signals in Four Areas of Macaque Frontal Cortex During Selection of Actions and Objects in Serial Order

Berdyyeva

Olson

2010

Journal of Neurophysiology

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Berdyyeva TK, Olson CR. Rank signals in four areas of macaque frontal cortex during selection of actions and objects in serial order. J Neurophysiol 104: 141-159, 2010. First published May 5, 2010 doi:10.1152/jn.00639.2009. Neurons in several areas of monkey frontal cortex exhibit ordinal position (rank) selectivity during the performance of serial order tasks. It has been unclear whether rank selectivity or the dependence of rank selectivity on task context varies across the areas of frontal cortex. To resolve this issue, we recorded from neurons in the supplementary motor area (SMA), presupplementary motor area (pre-SMA), supplementary eye field (SEF), and dorsolateral prefrontal cortex (dlPFC) as monkeys performed two oculomotor tasks, one requiring the selection of three actions in sequence and the other requiring the selection of three objects in sequence. We found that neurons representing all ranks were present in all areas. Only to a moderate degree did the prevalence and nature of rank selectivity vary from area to area. The two most prominent inter-area differences involved a lower prevalence of rank selectivity in the dlPFC than in the other areas and a higher proportion of neurons preferring late ranks in the SMA and SEF than in the other areas. Neurons in all four areas are rank generalists in the sense of favoring the same rank in both the serial action task and the serial object task.

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Role of the supplementary motor area in motor deficit following medial frontal lobe surgery

Abstract: fMRI is able to identify the area at risk in the SMA proper whose resection is highly related to the occurrence of the motor deficit. The clinical characteristics of this deficit support the role of the SMA proper in the initiation and execution of the movement.

Cited by 181 publications

References 26 publications

Posterior SMA Syndrome following subcortical stroke: Contralateral akinesia reversed by visual feedback

Posterior SMA Syndrome following subcortical stroke: Contralateral akinesia reversed by visual feedback

Neurobiology of culturally common maternal responses to infant cry

Rank Signals in Four Areas of Macaque Frontal Cortex During Selection of Actions and Objects in Serial Order

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