Abstract:The majority of mitochondrial precursor proteins are imported through the Tom40 beta-barrel channel of the translocase of the outer membrane (TOM). The sorting and assembly machinery (SAM) is essential for beta-barrel membrane protein insertion into the outer membrane and thus required for the assembly of the TOM complex. Here we demonstrate that the alpha-helical outer membrane protein Mco6 forms a complex with the mitochondrial distribution and morphology protein Mdm10 as part of the SAM machinery. Moreover,… Show more
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