Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth hormone secretion.

Mota, André Lupp; Bento, Allisson Freire; Peñalva, A; Pombo, Manuel; Diéguez, Carlos

doi:10.1210/jcem.80.6.7775648

Cited by 19 publications

(14 citation statements)

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“…It is possible that the stimulatory effect of serotonin on GH secretion is limited to specific periods of development. The serotoninergic 5-HT 1 and 5-HT 2 receptor subtypes have been shown to be involved as stimulatory elements in the control of GH in dogs (37) and in humans (38), whereas GH secretion seems to be independent of the degree of activation of 5-HT 3 receptors (37). In neonatal rats, it has been proposed that changes in serotoninergic activity at 5-HT 2 receptors mediates the inhibition of GH secretion in maternal separation (31).…”

Section: Discussionmentioning

confidence: 99%

5-HT1 and 5-HT2 receptor agonists blunt +/- -alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-stimulated GH secretion in prepubertal male rats

Pinilla

González²,

Tena‐Sempere³

et al. 2001

European Journal of Endocrinology

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Objective: Excitatory amino acids, g-amino butyric acid (GABA), serotonin and catecholamines are involved in the control of GH secretion. The actions of these neurotransmitters are interconnected, and recently we showed that the stimulatory effect of GABA was blocked by MK-801, an antagonist of N-methyl-D-aspartate receptors. The present experiments were carried out to analyze the interrelationships between (^)-a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors and serotoninergic and catecholaminergic pathways in the control of GH secretion in prepubertal (16±23-day-old) male rats. Design and Methods: The GH response to AMPA was analyzed in animals pretreated with 5-hydroxytryptophan methyl ester (5-HTP) plus fluoxetine (a precursor of 5-hydroxytryptamine (5-HT) synthesis and a blocker of 5-HT re-uptake), R (+)-8-hydroxydipropylaminotetralin hydrobromide (8-OH-DPAT, an agonist of the 5-HT 1 receptors), (^)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) and a-methyl-5-hydroxytryptamine (agonists of 5-HT 2 receptors), I-phenylbiguanide (an agonist of 5-HT 3 receptors), or a-methyl-p-tyrosine (a-MPT) and diethyldithiocarbamate (DDC) (blockers of catecholamine synthesis). Results: Basal GH secretion remained unchanged in prepubertal rats after activation of the serotoninergic system or blockade of catecholamine synthesis. The stimulatory effect of AMPA on GH secretion was blocked after activation of the serotoninergic system, through specific 5-HT 1 and 5-HT 2 receptor agonists. In contrast, activation of 5-HT 3 receptors potentiated AMPA-stimulated GH secretion. Conclusions: Serotoninergic receptors modulate the stimulatory effect of AMPA on GH secretion in prepubertal male rats.

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Section: Discussionmentioning

confidence: 99%

5-HT1 and 5-HT2 receptor agonists blunt +/- -alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-stimulated GH secretion in prepubertal male rats

Pinilla

González²,

Tena‐Sempere³

et al. 2001

European Journal of Endocrinology

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“…Stimulation of 5HT 1d receptors may also inhibit the release of somatosta- tin thereby decreasing inhibitory tone on GH release (Mota et al 1995).…”

Section: Discussionmentioning

confidence: 99%

“…The 5HT 1d receptor has both alpha and beta subtypes, however sumatriptan binds nonspecifically to both subtypes (Bard et al 1996). Sumatriptan has been shown to increase growth hormone release in normal controls (Franceschini et al 1994) via increased growth hormone releasing hormone (GHRH) which stimulates GH release, and inhibition of somatostatin which inhibits GH release (Yatham et al 1997;Mota et al 1995). Anecdotal case reports have suggested that sumatriptan improved symptoms of autism, as well as migraine headaches when taken by patients who suffer from both disorders.…”

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confidence: 99%

The Relationship between Repetitive Behaviors and Growth Hormone Response to Sumatriptan Challenge in Adult Autistic Disorder

Hollander

2000

Neuropsychopharmacology

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Autism is heterogeneous with respect to clinical symptoms and etiology. To sort out this heterogeneity in autismAutism is heterogeneous with respect to clinical symptoms and etiology. To sort out this heterogeneity in autism, one might determine whether specific neurobiological markers vary in parallel to key clinical symptoms. Autism is characterized by three unique behavioral dimensions: social impairment, communication difficulties and rigid, restricted interests, and repetitive behaviors. One recent study explored the relationship between repetitive behaviors in autism and D8/17, a B-lymphocyte antigen marker expressed at increased levels in patients with rheumatic fever, as well as in patients with neuropsychiatric disorders characterized by repetitive behaviors such as Sydenham's chorea, Tourette's syndrome and obsessivecompulsive disorder. Of interest, obsessive compulsive disorder (OCD) occurs with increased frequency in first degree relatives of autistic patients and is associated with the broader phenotype of autism (Bolton et al. 1998). D8/17 expression was found to be significantly positively correlated with the severity of repetitive behaviors as measured by the Yale-Brown Obsessive Compulsive Scale-compulsivity subscale in childhood and adolescent autism . We have hypothesized that repetitive behaviors in autism may also be related to serotonergic (5-HT) dysfunction (Hollander et al. 1998).Pharmacological treatment studies support a role of 5-HT in autistic disorders. (Mehlinger et al. 1990) and sertraline (Steingard et al. 1997) have documented efficacy in treating both global autistic symptoms as well as symptoms of repetitive behaviors and restricted interests in up to 60% of patients treated.Several biological studies have also suggested 5-HT dysregulation in autistic patients, however the findings have not been uniform, but rather replicated in subgroups of patients. For example, contradictory results in linkage disequilibrium analyses of two common alleles (long and short) of the 5HT transporter (5HTT) gene have been reported. While there was linkage between the short allele and a narrowly defined group of autistic probands (Cook et al. 1997), an association between the long allele and a more broadly defined group of autistic probands has also been reported (Klauck et al. 1997).Pharmacological challenge studies with 5-hydroxytryptophan and fenfluramine have demonstrated reduced prolactin response in some patients with autism (Hoshino et al. 1984;McBride et al. 1989), however age, gender, and racial/ethnic factors may account for some of the heterogeneity. Depletion of the 5-HT precursor, tryptophan, induced a worsening of autistic symptoms in some, but not all, patients (McDougle et al. 1996a). There is evidence for increased whole blood serotonin not only in patients with autism (Hoshino et al. 1984;Anderson et al. 1987), but also in their first degree relatives (Piven et al. 1991;Cook et al. 1994;Leboyer et al. 1999). Of interest, parents of autistic patients with increased whole blood ser...

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“…GH, also called somatotropin, is a hormone produced in the adenohypophysis. It exerts its action in all cells of the body, promoting secretion of GH, and then in the absence of SS, GHRH works better in stimulating the release of pituitary GH 14 . 5HT mainly causes the release of pituitary GH through serotonergic projections that, from the medial and dorsal raphe nuclei of the brainstem, reach the hypothalamus.…”

Section: Ht/ghmentioning

confidence: 99%

Serotonin/growth hormone/insulin-like growth factors axis on pre- and post-natal development: A contemporary review

Musumeci¹,

Trovato²,

Avola³

et al. 2013

OA Anatomy

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Introduction l-tryptophan is the precursor of serotonin. Serotonin regulates the secretion of pituitary growth hormonewhich in turn stimulates production of insulin-like growth factors (IGFs). IGFs are necessary for development and growth.We reviewed the most recent literature regarding the role of serotonin/growth hormone/IGF-I axis on development and growth. The link between serotonin, growth hormone and IGF production is widely reported in the literature. Many studies demonstrate impaired growth and development in off spring of pregnant rats with low levels of plasmatic serotonin. The most recent literature shows the possible negative influence of serotonin in excess on differentiation of serotonergic neurons with consequent reduction in pituitary growth hormone production, which has a direct effect on hepatic production of IGF-I, particularly in the post-natal period. Recent literature also shows that hyperserotonemia in pregnant rats causes disorders in offspring, such as lower body mass and a lower survival rate. In addition, data show that high serotonin levels could inhibit development of serotonin neurons and lead to

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Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth hormone secretion.

Cited by 19 publications

References 0 publications

5-HT1 and 5-HT2 receptor agonists blunt +/- -alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-stimulated GH secretion in prepubertal male rats

5-HT1 and 5-HT2 receptor agonists blunt +/- -alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-stimulated GH secretion in prepubertal male rats

The Relationship between Repetitive Behaviors and Growth Hormone Response to Sumatriptan Challenge in Adult Autistic Disorder

Serotonin/growth hormone/insulin-like growth factors axis on pre- and post-natal development: A contemporary review

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