Role of the Red Ginseng in Defense against the Environmental Heat Stress in Sprague Dawley Rats

Kim, Kui-Jin; Yoon, Kye-Yoon; Hong, Hee‐Do; Lee, Boo-Yong

doi:10.3390/molecules201119692

Cited by 15 publications

(12 citation statements)

References 62 publications

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“…The differential mRNA expression patterns of HSPB1 and HSP70 indicate that ginseng extract helps these organisms combat heat stress, mainly in an ATP-independent manner, which avoids spending excess ATP on survival and may shift energy flux to growth performance. Consistent with our findings, several studies have shown that ginseng extract inhibited the expression of HSP70 (mRNA and protein levels) in heat-stressed rats [21,35]. In contrast, Yeo et al reported that ginseng extract has a cytoprotective effect on ethanol-induced gastric damage through the induction of HSP70 [36].…”

Section: Discussionsupporting

confidence: 91%

“…Ginsenoside of wild ginseng prevents the decrease in zonula occludens-1 in colonic epithelial cells from a murine colitis model, suggesting that ginseng is effective in the production and maintenance of tight junctions and in improving intestinal barrier function [20]. Kim and co-workers observed that red ginseng administered to rats during heat stress drastically suppressed lipid peroxidation and ROS-associated gene expression [21]. In addition, red ginseng decreased the gene expression of heat shock protein 70 without alleviating the weight loss of rats under heat stress [21].…”

Section: Introductionmentioning

confidence: 99%

“…Kim and co-workers observed that red ginseng administered to rats during heat stress drastically suppressed lipid peroxidation and ROS-associated gene expression [21]. In addition, red ginseng decreased the gene expression of heat shock protein 70 without alleviating the weight loss of rats under heat stress [21]. To the best of our knowledge, only a few systematic studies are available on the effects of ginseng extract on animal performance under heat stress, on heat shock protein response and on intestinal barrier integrity.…”

Section: Introductionmentioning

confidence: 99%

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Ginseng Extract Ameliorates the Negative Physiological Effects of Heat Stress by Supporting Heat Shock Response and Improving Intestinal Barrier Integrity: Evidence from Studies with Heat-Stressed Caco-2 Cells, C. elegans and Growing Broilers

Sandner

Mueller²,

Zhou³

et al. 2020

Molecules

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Climatic changes and heat stress have become a great challenge in the livestock industry, negatively affecting, in particular, poultry feed intake and intestinal barrier malfunction. Recently, phytogenic feed additives were applied to reduce heat stress effects on animal farming. Here, we investigated the effects of ginseng extract using various in vitro and in vivo experiments. Quantitative real-time PCR, transepithelial electrical resistance measurements and survival assays under heat stress conditions were carried out in various model systems, including Caco-2 cells, Caenorhabditis elegans and jejunum samples of broilers. Under heat stress conditions, ginseng treatment lowered the expression of HSPA1A (Caco-2) and the heat shock protein genes hsp-1 and hsp-16.2 (both in C. elegans), while all three of the tested genes encoding tight junction proteins, CLDN3, OCLN and CLDN1 (Caco-2), were upregulated. In addition, we observed prolonged survival under heat stress in Caenorhabditis elegans, and a better performance of growing ginseng-fed broilers by the increased gene expression of selected heat shock and tight junction proteins. The presence of ginseng extract resulted in a reduced decrease in transepithelial resistance under heat shock conditions. Finally, LC-MS analysis was performed to quantitate the most prominent ginsenosides in the extract used for this study, being Re, Rg1, Rc, Rb2 and Rd. In conclusion, ginseng extract was found to be a suitable feed additive in animal nutrition to reduce the negative physiological effects caused by heat stress.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ginseng Extract Ameliorates the Negative Physiological Effects of Heat Stress by Supporting Heat Shock Response and Improving Intestinal Barrier Integrity: Evidence from Studies with Heat-Stressed Caco-2 Cells, C. elegans and Growing Broilers

Sandner

Mueller²,

Zhou³

et al. 2020

Molecules

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“…Physical stress in the form of exposure to excess heat (Mujahid et al ., 2007 ; Reuter et al ., 2010 ; Kaldur et al ., 2014; Kim et al ., 2015 ), chronic inflammation (Khansari et al ., 2009 ; Tremellen, 2008 ) or chronic physical trauma, an example of which is chronic traumatic encephalopathy (CTE) (Miller & Sadeh, 2014 ; Faden & Loane, 2015 ), all cause OS.…”

Section: Resultsmentioning

confidence: 99%

Review article. Predicting disease onset in clinically healthy people

Zeliger

2016

Interdisciplinary Toxicology

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Virtually all human disease is induced by oxidative stress. Oxidative stress, which is caused by toxic environmental exposure, the presence of disease, lifestyle choices, stress, chronic inflammation or combinations of these, is responsible for most disease. Oxidative stress from all sources is additive and it is the total oxidative stress from all sources that induces the onset of most disease. Oxidative stress leads to lipid peroxidation, which in turn produces Malondialdehyde. Serum malondialdehyde level is an additive parameter resulting from all sources of oxidative stress and, therefore, is a reliable indicator of total oxidative stress which can be used to predict the onset of disease in clinically asymptomatic individuals and to suggest the need for treatment that can prevent much human disease.

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“…The accumulating evidence indicated heat stress has a severe effect on the health of animals and cause endocrine changes such as in measurable levels of circulating cytokines and corticosteroids [21], and gene expression including specific and highly regulated signaling cascades leading to the transcriptional regulation of endogenous antioxidant enzymes [22]. Through transcriptomic analysis of broilers under high ambient temperature, Coble et al [3] found the DEGs were mainly associated with cell signaling and endocrine system development and function.…”

Section: Discussionmentioning

confidence: 99%

Liver Transcriptome Changes of Hyla Rabbit in Response to Chronic Heat Stress

Yang

Chen

et al. 2019

Animals

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Simple Summary: It has been widely acknowledged in farm animals that environmental heat stress would have comprehensive influences on many kinds of physiological aspects, including the metabolic characteristics, production performances, welfare concerns, etc. The rabbit is a small herbivore and needs to regulate the body temperature in a fine mechanism. Little is known, however, about the genes and pathways that are involved in the regulatory responses under chronic heat stress conditions. In the present study, we investigated the liver transcriptome changes in response to chronic heat stress for Hyla rabbit, that is a commercial meat breed recently introduced into China. We successfully revealed the differentially expressed genes that were significantly enriched in heat stress related biological processes. The results would help us for better understanding the molecular mechanisms underlying physiological responses against heat stress in rabbits.Abstract: Rabbit is an economically important farm animal in China and also is a widely used animal model in biological researches. Rabbits are very sensitive to the environmental conditions, therefore we investigated the liver transcriptome changes in response to chronic heat stress in the present study. Six Hyla rabbits were randomly divided into two groups: chronic heat stress (HS) and controls without heat stress (CN). Six RNA-Seq libraries totally yielded 380 million clean reads after the quality filtering. Approximately 85.07% of reads were mapped to the reference genome. After assembling transcripts and quantifying gene expression levels, we detected 51 differentially expressed genes (DEGs) between HS and CN groups with thresholds of the adjusted p-value < 0.05 and |log2(FoldChange)| > 1. Among them, 33 and 18 genes were upregulated and downregulated, respectively. Gene ontology analyses further revealed that these DEGs were mainly associated with metabolism of lipids, thyroid hormone metabolic process, and cellular modified amino acid catabolic process. The upregulated ACACB, ACLY, LSS, and CYP7A1 genes were found to be inter-related through biological processes of thioester biosynthetic process, acyl-CoA biosynthetic process, acetyl-CoA metabolic process, and others. Six DEGs were further validated by quantitative real-time PCR analysis. The results revealed the candidate genes and biological processes that will potentially be considered as important regulatory factors involved in the heat stress response in rabbits.

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Role of the Red Ginseng in Defense against the Environmental Heat Stress in Sprague Dawley Rats

Cited by 15 publications

References 62 publications

Ginseng Extract Ameliorates the Negative Physiological Effects of Heat Stress by Supporting Heat Shock Response and Improving Intestinal Barrier Integrity: Evidence from Studies with Heat-Stressed Caco-2 Cells, C. elegans and Growing Broilers

Ginseng Extract Ameliorates the Negative Physiological Effects of Heat Stress by Supporting Heat Shock Response and Improving Intestinal Barrier Integrity: Evidence from Studies with Heat-Stressed Caco-2 Cells, C. elegans and Growing Broilers

Review article. Predicting disease onset in clinically healthy people

Liver Transcriptome Changes of Hyla Rabbit in Response to Chronic Heat Stress

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