Role of the posterior mucosal defense barrier in portal hypertensive gastropathy

Yi, Zhiqiang; Zhang, Minglin; Ma, Zhiyuan; Tuo, Biguang; Liu, Aimin; Deng, Zilin; Zhao, Yingying; Li, Taolang; Liu, Xuemei

doi:10.1016/j.biopha.2021.112258

Cited by 5 publications

(2 citation statements)

References 119 publications

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“…Portal hypertension can promote short circuits in the gastric mucosal layer and submucosa, resulting in insufficient blood supply and oxygen to gastric mucosal cells. Portal hypertension can cause backflow obstruction and congestion of small blood vessels in the gastric mucosa, thus weakening the mucosal defence barrier [17]. Liver hypofunction activates kinins and then limits vasoconstriction, leading to gastric mucosa repair disorders.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for portal hypertensive gastropathy

Liu

Shi

et al. 2022

BMC Gastroenterol

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Background Portal hypertensive gastropathy (PHG) is often underestimated in clinical diagnosis. Gastrointestinal bleeding in cirrhosis of PHG accounts for approximately 10% of upper gastrointestinal bleeding. However, the relationship between PHG and gender, laboratory parameters, liver function and varices is still controversial. In the present study, we aimed to retrospectively evaluate the incidence of PHG and to explore the relationship between PHG and gender, laboratory parameters, liver function and varicose veins. Methods A retrospective analysis of 325 patients with cirrhosis who underwent esophagogastroduodenoscopy (EGD) in the Department of Gastroenterology of the Second Hospital of Hebei Medical University from 1 January 2018 to 31 December 2020 was performed. The relationships among age, gender, laboratory parameters, Child–Pugh stage, oesophageal varices (EV), gastric varices (GV) and ascites with PHG were analysed with univariate and multivariate logistic regression. Results The occurrence of PHG was significantly associated with gender, haemoglobin, platelet count, prothrombin time, albumin, Child–Pugh stage, EV, GV and ascites (P < 0.05). Furthermore, there was a positive correlation between the severity of PHG and the degree of EV, GV and ascites (P < 0.05). Multivariate logistic regression showed that albumin, EV and GV levels were independently associated with the occurrence of PHG. Conclusion The incidence of PHG in cirrhosis was 87.4% in this study. The occurrence of PHG was related to gender, haemoglobin, platelet count, prothrombin time, albumin, Child–Pugh stage, EV, GV and ascites. Albumin, the degree of EV and GV are independent risk factors for the occurrence of PHG.

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Section: Discussionmentioning

confidence: 99%

Risk factors for portal hypertensive gastropathy

Liu

Shi

et al. 2022

BMC Gastroenterol

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“…This ability that could be of production in various endogenous basic mediators in mucosa, such as PGE 2 , leukotrienes, procoagulants, NO, ET, EGF and others. These mediators regulate the circulation in the stomach, which make it closely related to the pathogenesis and healing of GI lesions ( Yi, et al, 2021 ). Numerous studies have demonstrated that TCMs have therapeutic effects on the GMBF barrier, which can alleviate blood circulation imbalances and vascular dysfunction.…”

Section: Repairs To the Gmbf Barriermentioning

confidence: 99%

Pharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury

Jia,

He,

et al. 2023

Front. Pharmacol.

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Introduction: The gastric mucosa (GM) is the first barrier and vital interface in the stomach that protects the host from hydrochloric acid in gastric juice and defends against exogenous insults to gastric tissues. The use of traditional Chinese medications (TCMs) for the treatment of gastric mucosal injury (GMI) has long-standing history and a good curative effect. Whereas there are poor overall reports on the intrinsic mechanisms of these TCM preparations that pharmacology uses to protect body from GMI, which is crucial to treating this disease. These existing reviews have deficiencies that limit the clinical application and development of both customary prescriptions and new drugs.Methods: Further basic and translational studies must be done to elucidate the intrinsic mechanisms of influence of these TCM preparations. Moreover, well-designed and well-conducted experiences and clinical trials are necessary to ascertain the efficacy and mechanisms of these agents. Therefore, this paper presents a focused overview of currently published literature to assess how TCMs action that facilitates the cures for GMI. It offers a whole train of current state of pharmacological evidence, identifies the pharmacological mechanisms of TCMs on GM, and highlights that remarkable capacity of TCMs to restore GM after damage.Results: These TCMs preparations promote the repair of multicomponent targets such as the gastric mucus, epithelial layer, blood flow (GMBF) and lamina propria barrier.Summary: Overall, this study has summarized the essential regulatory mechanisms and pharmacological efficacy of TCMs on new and productive therapeutic targets.Discussion: This review provides an avenue for studying various drugs with potentially promising effects on mucosal integrity, as well as subsequent pharmacological studies, clinical applications, and new drug development.

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Molecular mechanism of portal hypertensive gastropathy: An update

Tan

2024

Clinics and Research in Hepatology and Gastroenterology

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Role of the posterior mucosal defense barrier in portal hypertensive gastropathy

Cited by 5 publications

References 119 publications

Risk factors for portal hypertensive gastropathy

Risk factors for portal hypertensive gastropathy

Pharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury

Molecular mechanism of portal hypertensive gastropathy: An update

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