Role of the Peroxisome Proliferator‐Activated Receptors, Adenosine       Monophosphate‐Activated Kinase,  and Adiponectin in the Ovary

Dupont, Joëlle; Chabrolle, Christine; Ramé, Christelle; Tosca, Lucie; Coyral-Castel, Stéphanie

doi:10.1155/2008/176275

Cited by 47 publications

(62 citation statements)

References 90 publications

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“…This conclusion is also supported by the absence of AMPK activation in chicken brain, liver, or skeletal muscle in response to a 24-h fast; AMPK was, however, activated in muscle after a 48-h fast (Proszkowiec-Weglarz et al 2006). In contrast, in the ovary of several species, including hen, AMPK activity varies during follicle development, independently of nutrition level (Dupont et al 2008). In the present study, it was of interest to investigate whether the expression of some genes and proteins, known as insulin sensitive in mammals, had been altered in the liver or the muscle following insulin privation (5hrfed-Ab).…”

Section: Discussionmentioning

confidence: 77%

Insulin immuno-neutralization in chicken: effects on insulin signaling and gene expression in liver and muscle

Dupont

Tesseraud

Derouet

et al. 2008

Journal of Endocrinology

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In order to evaluate the role of insulin in chicken, an insulin immuno-neutralization was performed. Fed chickens received 1 or 3 i.v. injections of anti-insulin serum (2-h intervals), while fed or fasted controls received normal serum. Measurements included insulin signaling cascade (at 1 h in liver and muscle), metabolic or endocrine plasma parameters (at 1 and 5 h), and qRT-PCR analysis (at 5 h) of 23 genes involved in endocrine regulation, metabolisms, and transcription. Most plasma parameters and food intake were altered by insulin privation as early as 1 h and largely at 5 h. The initial steps of insulin signaling pathways including insulin receptor (IR), IR substrate-1 (IRS-1), and Src homology collagen and downstream elements: phosphatidylinositol 3-kinase (PI3K), Akt, GSK3, ERK2, and S6 ribosomal protein) were accordingly turned off in the liver. In the muscle, IR, IRS-1 tyrosine phosphorylation, and PI3K activity remained unchanged, whereas several subsequent steps were altered by insulin privation. In both tissues, AMPK was not altered. In the liver, insulin privation decreased Egr1, PPARg, SREBP1, THRSPa (spot14), D2-deiodinase, glucokinase (GK), and fatty acid synthase (whereas D3-deiodinase and IGF-binding protein1 transcripts were up-regulated. Liver SREBP1 and GK and plasma IGFBP1 proteins were accordingly downand up-regulated. In the muscle, PPARbd and atrogin-1 mRNA increased and Egr1 mRNA decreased. Changes in messengers were partly mimicked by fasting. Thus, insulin signaling in muscle is peculiar in chicken and is strictly dependent on insulin in fed status. The 'diabetic' status induced by insulin immuno-neutralization is accompanied by impairments of glucagon secretion, thyroid axis, and expression of several genes involved in regulatory pathways or metabolisms, evidencing pleiotropic effects of insulin in fed chicken.

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Section: Discussionmentioning

confidence: 77%

Insulin immuno-neutralization in chicken: effects on insulin signaling and gene expression in liver and muscle

Dupont

Tesseraud

Derouet

et al. 2008

Journal of Endocrinology

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“…Many studies have shown that PPARs gene and/or protein expression varies depending on ovarian cell type, physiological status and the species [14,[22][23][24][25][26]. It has also been frequently reported that PPARs are engaged in the regulation of various ovarian functions.…”

Section: Ppars In the Ovarymentioning

confidence: 99%

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Bogacka

Kurzyńska

Bogacki

et al. 2015

Folia Histochem Cytobiol.

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Peroxisome proliferator-activated receptors (PPARs) belong to a ligand-dependent nuclear receptor family. In the past decade, numerous studies have revealed the presence and significance of PPARs in the reproductive system. PPARs are expressed at different levels of hypothalamic-pituitary-gonadal (HPG) axis. They are also present in the uterus as well as in the placenta and embryonic tissues of different species. PPARs significance has been reported during the estrous/menstrual cycle and pregnancy with the gamma isoform studied most frequently. Several studies indicate that PPARs regulate proliferation of ovarian cells, tissue remodeling and steroidogenesis. In the endometrium, PPARs are engaged in the regulation of prostaglandins, steroids and cytokines synthesis. The role of PPARs in the trophoblast differentiation, maturation and invasion as well as in the embryo development has also been demonstrated. In this review, we summarize current findings concerning the role of PPARs in the regulation of reproductive functions at different levels of the HPG axis during various physiological statuses of females. In addition, the role of PPARs in the modulation of uterine functions as well as the placenta and embryo development has also been discussed.

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“…Although not all known PKs are demonstrated in the ovary, presence of members of MAPK, CDK, TK, PI3K, Akt, PKA, AK, HER kinases, mTOR and activin receptor like kinase (ALK) families in ovarian follicular granulosa cells has been well documented (Sirotkin et al, 2000a(Sirotkin et al, , 2004Shimada et al, 2001;Makarevich et al, 2002Makarevich et al, , 2004bHunzicker-Dunn and Maizels, 2006;Kumar et al, 2007;Sawada et al, 2007;Wang and Tsang, 2007;Dupont et al, 2008). Furthermore, observations of effects of activators and blockers of PKs indicate presence and importance of a number of other PKs in control of ovarian functions and in mediating effect of hormones on these functions (see below).…”

Section: Presence Of Protein Kinases In the Ovarymentioning

confidence: 99%

“…Despite the importance of PKs, the reviews concerning ovarian PKs published previously are focused on one PK (protein kinase A- Dupont, 2008, Aurora kinase- Macarulla et al, 2008) or particular group of PKs (Ca2þ-dependent PKs- Ducibella and Fissore, 2008), one ovarian structure (oocyte- Brunet and Maro, 2005;Dekel, 2005;Kimura et al, 2007; Corpus luteum -Diaz et al, 2002;Meidan et al, 2005;Gadsby et al, 2006), particular process (oogenesis- Brunet and Maro, 2005;Dekel, 2005;Kimura et al, 2007, cancerogenesis-Kamath andBuolamwini, 2006;Martin and Schilder, 2006;Markman, 2008) or hormone (FSH-Hillier, 2001;Richards et al, 2002;Hunzicker-Dunn and Maizels, 2006;Dupont et al, 2008). To our knowledge, no attempts to put together available data concerning involvement of different known PKs in control of different ovarian processes have been previously made.…”

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confidence: 99%

Protein kinases and ovarian functions

Sirotkin

Makarevich

Grosmann³

2010

Journal Cellular Physiology

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The present focus survey represents a short review of current knowledge concerning involvement of protein kinases in control of basic ovarian functions. Ovarian cells produce a number of protein kinases, whose expression depends on type of cells, their state and action of hormones and other protein kinases. A number of protein kinases are involved in control of ovarian cell proliferation, apoptosis, oocyte maturation, hormone release, reception and response to hormones, as well as in mediating action of hormones on these ovarian functions. Complexity of interrelationships between different protein kinase-dependent signaling pathways occurs. Protein kinases and their regulators could be used for characterization, prediction and control of ovarian folliculogenesis and atresia, Corpus luteum functions, oocyte maturation, fertility, release of hormones, response of ovarian structures to hormonal regulators, as well as for treatment of some reproductive disorders. The present data demonstrate importance of protein kinases in control of basic ovarian function and potential usage of protein kinases for characterization, prediction and control of these functions.

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Role of the Peroxisome Proliferator‐Activated Receptors, Adenosine Monophosphate‐Activated Kinase, and Adiponectin in the Ovary

Cited by 47 publications

References 90 publications

Insulin immuno-neutralization in chicken: effects on insulin signaling and gene expression in liver and muscle

Insulin immuno-neutralization in chicken: effects on insulin signaling and gene expression in liver and muscle

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Protein kinases and ovarian functions

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