Role of the oxidative stress index, myeloperoxidase, catalase activity for cardiac allograft vasculopathy in heart transplant recipients

Kargın, Ramazan; Emiroğlu, Mehmet Yunus; Evlice, Mert; Çelık, Mehmet; Toprak, Aybala Erek; Avcı, Anıl; Aytürk, Mehmet; Külahçıoğlu, Şeyhmus; Bulut, Mustafa; Çalışkan, Mustafa

doi:10.1111/ctr.13273

Cited by 8 publications

(9 citation statements)

References 45 publications

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“…In accordance with Kargin et al's report [ 4 ], we observed that in patients with angiographic evidence of CAV, the antioxidant mechanisms were exhausted, as evidenced by a significantly lower TAC level in patients with CAV than in those without CAV. Furthermore, we found increased secretion of ROS, identified by higher values of TOS and OSI in patients with CAV than in those without CAV.…”

Section: Discussionsupporting

confidence: 92%

“…Oxidative-antioxidative balance disorders in the prooxidative direction cause a cascade of changes that lead to damage of the vascular endothelium, constituting the main point of CAV development. Permanent smoldering, low-grade vascular inflammation, and oxidative stress cause progressive endothelial damage in the coronary arteries, leading to CAV initiation and progression [ 4 , 5 , 7 ]. To minimize damage caused by ROS, the body uses enzymatic and nonenzymatic antioxidant systems that restore the proper oxidative-antioxidant balance [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, new noninvasive sensitive and specific tools are necessary for detecting CAV early, which may result in the modification of immunosuppressive therapy, increase in statin doses, and intensive treatment of CAV-related comorbidities. There are numerous immune and nonimmune factors in the donor and recipient that are related to the presence of CAV, but a clear concept of the pathophysiological pathways associated with the development and progression of CAV is still lacking, in particular regarding the role of oxidative stress in CAV development [ 4 , 5 ]. Oxidative stress is defined as an imbalance between the production of reactive oxygen species (ROS) and the ability of antioxidant mechanisms to neutralize it [ 4 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…There are numerous immune and nonimmune factors in the donor and recipient that are related to the presence of CAV, but a clear concept of the pathophysiological pathways associated with the development and progression of CAV is still lacking, in particular regarding the role of oxidative stress in CAV development [ 4 , 5 ]. Oxidative stress is defined as an imbalance between the production of reactive oxygen species (ROS) and the ability of antioxidant mechanisms to neutralize it [ 4 , 6 ]. Disturbances in the balance of the oxidative-antioxidative system lead to damage to the vascular endothelium, which regulates the flow of macromolecules and cells circulating from the blood to the tissues, increases vascular endothelial permeability, and promotes leukocyte adhesion, which are combined with changes in endothelial signal transduction and transcription-regulated factors, influencing the initiation and progression of CAV [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the Role of Oxidative Stress and Factors Associated with Cardiac Allograft Vasculopathy in Patients after Heart Transplantation

Szczurek

Gąsior

Romuk

et al. 2020

Oxidative Medicine and Cellular Longevity

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Oxidative stress is defined as an imbalance between the production of free radicals and their elimination by the antioxidant defense system. However, the role of oxidative stress in cardiac allograft vasculopathy (CAV) has not been fully understood. Therefore, this study is aimed at determining the role of oxidative-antioxidative balance disturbances in patients after HT. Furthermore, we sought to analyze factors associated with the presence of CAV, with particular emphasis placed on oxidative stress markers. The study analyzed data of 194 consecutive patients after HT who underwent routine visits in the Transplantation Clinic between 2015 and 2016. Total oxidant status (TOS) and total antioxidant capacity (TAC) were measured by the method described by Erel. The oxidative stress index (OSI) was defined as the ratio of the TOS to TAC levels. Patients’ mean age was 55.4±15.0 years, and 73.4% were men. The frequency of CAV was 50%. The area under the receiver operating characteristic curves indicated a good discriminatory power of TAC and TOS (0.8940 (0.8515-0.9365); 0.8620 (0.8126-0.9114), respectively) as well as excellent discriminatory power of OSI (0.9530 (0.9279-0.9781)) for CAV detection. Multivariate analysis of the Cox proportional hazard model confirmed that OSI (hazard ratio HR=1.294 (1.204-1.391), p<0.0001), age (HR=1.023 (1.006-1.041), p=0.0091), and high-sensitivity C-reactive protein (HR=1.049 (1.016-1.083), p=0.0151) were independently associated with CAV presence. In conclusion, TAC and TOS had a good discriminatory power and OSI had excellent strength for detecting CAV. The independent factors of CAV were higher OSI and CRP levels, as well as older recipient age.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of the Role of Oxidative Stress and Factors Associated with Cardiac Allograft Vasculopathy in Patients after Heart Transplantation

Szczurek

Gąsior

Romuk

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Oxidative as well as antioxidative pathways are involved in various immune and inflammatory reactions and may play a role in the development of transplant vasculopathy [3]. As for heart transplant recipients, an increase in oxidative stress and antioxidant enzyme activity was shown to be associated with development of cardiac allograft vasculopathy [4].…”

Section: Introductionmentioning

confidence: 99%

Sodium Sulfite Exacerbates Allograft Vasculopathy and Affects Tryptophan Breakdown in Murine Heterotopic Aortic Transplantation

Sucher

Hautz

Mohr

et al. 2019

Oxidative Medicine and Cellular Longevity

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Graft vasculopathy is the main feature of chronic rejection in organ transplantation, with oxidative stress being a major trigger. Inflammation-associated prooxidant processes may be controlled by antioxidants; however, interference with redox-regulated mechanisms is a complex endeavor. An essential feature of the cellular immune response is the acceleration of tryptophan (Trp) breakdown, leading to the formation of several bioactive catabolites. Long-term activation of this immunobiochemical pathway contributes to the establishment of a tolerogenic environment, thereby supporting allograft survival. Herein, the impact of the antioxidant sodium sulfite on the development of graft vasculopathy was assessed in murine aortic transplantation. Allogeneic (BALB/c to C57BL/6) heterotopic murine aortic transplantations were performed. Animals were left untreated or were treated with 10 μl of 0.1 M, of 0.01 M sodium sulfite, or of 0.1 M sodium sulfate, intraperitoneally once/day, until postoperative day (POD) 100. Grafts were assessed by histology, immunohistochemistry, and adhesion molecule gene expression. Serum concentrations of tryptophan and its catabolite kynurenine (Kyn) were measured. On day 100, graft vasculopathy was significantly increased upon treatment with 0.1 M sodium sulfite, compared to allogeneic untreated controls (p=0.004), which correlated with a significant increase of α-smooth-muscle-actin, Vcam-1, and P-selectin. Serum Kyn concentrations increased in the allogeneic control group over time (p<0.05, POD≥50), while low-dose sodium sulfite treatment (0.01 M) treatment resulted in a decrease in Kyn levels over time (p<0.05, POD≥10), compared to the respective baselines (p<0.05). Longitudinal analysis of serum metabolite concentrations in the different treatment groups further identified an overall effect of sodium sulfite on Kyn concentrations. Antioxidative treatment may result in ambivalent consequences. Our data reveal that an excess of antioxidants like sodium sulfite can aggravate allograft vasculopathy, which further highlights the challenges associated with interventions that interfere with the complex interplay of redox-regulated inflammatory processes.

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PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress

Lan

et al. 2023

Int J Oral Sci

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Xenogenic organ transplantation has been considered the most promising strategy in providing possible substitutes with the physiological function of the failing organs as well as solving the problem of insufficient donor sources. However, the xenograft, suffered from immune rejection and ischemia-reperfusion injury (IRI), causes massive reactive oxygen species (ROS) expression and the subsequent cell apoptosis, leading to the xenograft failure. Our previous study found a positive role of PPAR-γ in anti-inflammation through its immunomodulation effects, which inspires us to apply PPAR-γ agonist rosiglitazone (RSG) to address survival issue of xenograft with the potential to eliminate the excessive ROS. In this study, xenogenic bioroot was constructed by wrapping the dental follicle cells (DFC) with porcine extracellular matrix (pECM). The hydrogen peroxide (H2O2)-induced DFC was pretreated with RSG to observe its protection on the damaged biological function. Immunoflourescence staining and transmission electron microscope were used to detect the intracellular ROS level. SD rat orthotopic transplantation model and superoxide dismutase 1 (SOD1) knockout mice subcutaneous transplantation model were applied to explore the regenerative outcome of the xenograft. It showed that RSG pretreatment significantly reduced the adverse effects of H2O2 on DFC with decreased intracellular ROS expression and alleviated mitochondrial damage. In vivo results confirmed RSG administration substantially enhanced the host’s antioxidant capacity with reduced osteoclasts formation and increased periodontal ligament-like tissue regeneration efficiency, maximumly maintaining the xenograft function. We considered that RSG preconditioning could preserve the biological properties of the transplanted stem cells under oxidative stress (OS) microenvironment and promote organ regeneration by attenuating the inflammatory reaction and OS injury.

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Role of the oxidative stress index, myeloperoxidase, catalase activity for cardiac allograft vasculopathy in heart transplant recipients

Abstract: An increase in the serum level of OSI, MPO, and CAT was associated with CAV in HTRs.

Cited by 8 publications

References 45 publications

Investigation of the Role of Oxidative Stress and Factors Associated with Cardiac Allograft Vasculopathy in Patients after Heart Transplantation

Investigation of the Role of Oxidative Stress and Factors Associated with Cardiac Allograft Vasculopathy in Patients after Heart Transplantation

Sodium Sulfite Exacerbates Allograft Vasculopathy and Affects Tryptophan Breakdown in Murine Heterotopic Aortic Transplantation

PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress

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