Role of the nervous system in cancer metastasis

Kuol, Nyanbol; Stojanovska, Lily; Apostolopoulos, Vasso; Nurgali, Kulmira

doi:10.1186/s13046-018-0674-x

Cited by 107 publications

(94 citation statements)

References 156 publications

(162 reference statements)

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“…Neural microenvironment and cancer-related axonogenesis constitute new fields for investigation that require further exploration in PC and other neoplasms [18][19][20][21][22][25][26][27][28][29]. Future studies are needed to advance current understanding of molecular mechanism and neural signaling pathways that mediate neoneurogenesis and their impact on cancer development and progression.…”

Section: Discussionmentioning

confidence: 99%

“…The relevance of nerves infiltration for tumor dissemination was previously believed to be a mostly passive process in which nerves act as roots for cancer cell migration. However, studying the role of neurotrophic factors and NT secreted by axons and nerve endings, and also the active role of Schwann cells, has shed a new light on this mechanism [19,21,22]. In parallel, cancer cells are also able to release neurogenic factors and axon guidance molecules to promote new axon development within the tumors, in part similar to the process of angiogenesis.…”

Section: Pni In Pcmentioning

confidence: 99%

“…In vitro studies revealed that axonal stimulation may be related to more aggressive behavior and formation of distant metastases [22,78]. A study by Magnon et al [30] was pioneering in this area.…”

Section: Axonal Network In Tme and Nerve Fiber Density In Pcmentioning

confidence: 99%

“…Immune system regulation by neural tissue is supported mainly by the β-adrenergic pathway. In lung and breast in vitro cancer models, stimulation of β-adrenergic receptors resulted in increased metastatic potential of cancer cells among others via NK-cell, macrophages signaling or osteoblast stimulation [22]. Moreover, sympathetic nervous system regulates pathological gene expression in human tumors leading to DNA damage repair inhibition, oncogene activation, apoptosis and anoikis suppression [23].…”

Section: Introductionmentioning

confidence: 99%

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Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

et al. 2020

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The tumor microenvironment (TME) plays an essential role in the development and progression of neoplasms. TME consists of the extracellular matrix and numerous specialized cells interacting with cancer cells by paracrine and autocrine mechanisms. Tumor axonogenesis and neoneurogenesis constitute a developing area of investigation. Prostate cancer (PC) is one of the most common malignancies in men worldwide. During the past years, more and more studies have shown that mechanisms leading to the development of PC are not confined only to the epithelial cancer cell, but also involve the tumor stroma. Different nerve types and neurotransmitters present within the TME are thought to be important factors in PC biology. Moreover, perineural invasion, which is a common way of PC spreading, in parallel creates the neural niche for malignant cells. Cancer neurobiology seems to have become a new discipline to explore the contribution of neoplastic cell interactions with the nervous system and the neural TME component, also to search for potential therapeutic targets in malignant tumors such as PC.

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Section: Discussionmentioning

confidence: 99%

Section: Pni In Pcmentioning

confidence: 99%

Section: Axonal Network In Tme and Nerve Fiber Density In Pcmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

et al. 2020

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“…Interestingly, neurotransmitters and neuropeptides are also regulators of angiogenesis, and thus the nervous system has an influence on the vasculature [100]. Stimulation of the β-ARs increased the production of IL-6 in MDA-MB-231 and MDA-MB-231BR breast cancer cell lines and VEGF production in MDA-MB-231BR cells [101].…”

Section: The Role Of Nerve Cells In Bone Metastasesmentioning

confidence: 99%

Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment

et al. 2020

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Bone is the most common metastatic site in breast cancer. Upon arrival to the bone, disseminated tumor cells can undergo a period of dormancy but often eventually grow and hijack the bone microenvironment. The bone marrow microenvironment consists of multiple cell types including the bone cells, adipocytes, endothelial cells, and nerve cells that all have crucial functions in the maintenance of bone homeostasis. Tumor cells severely disturb the tightly controlled cellular and molecular interactions in the bone marrow fueling their own survival and growth. While the role of bone resorbing osteoclasts in breast cancer bone metastases is well established, the function of other bone cells, as well as adipocytes, endothelial cells, and nerve cells is less understood. In this review, we discuss the composition of the physiological bone microenvironment and how the presence of tumor cells influences the microenvironment, creating a pathological crosstalk between the cells. A better understanding of the cellular and molecular events that occur in the metastatic bone microenvironment could facilitate the identification of novel cellular targets to treat this devastating disease.

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Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges

Dang,

Zuo,

et al. 2024

Cancer Medicine

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BackgroundColorectal cancer (CRC) is among the most hackneyed malignancies. Even patients with identical clinical symptoms and the same TNM stage still exhibit radically different clinical outcomes after receiving equivalent treatment regimens, indicating extensive heterogeneity of CRC. Myriad molecular subtypes of CRC have been exploited for decades, including the most compelling consensus molecular subtype (CMS) classification that has been broadly applied for patient stratification and biomarker‐drug combination formulation. Encountering barriers to clinical translation, however, CMS classification fails to fully reflect inter‐ or intra‐tumor heterogeneity of CRC. As a consequence, addressing heterogeneity and precisely managing CRC patients with unique characteristics remain arduous tasks for clinicians.ReviewIn this review, we systematically summarize molecular subtypes of CRC and further elaborate on their clinical applications, limitations, and future orientations.ConclusionIn recent years, exploration of subtypes through cell lines, animal models, patient‐derived xenografts (PDXs), organoids, and clinical trials contributes to refining biological insights and unraveling subtype‐specific therapies in CRC. Therapeutic interventions including nanotechnology, clustered regulatory interspaced short palindromic repeat/CRISPR‐associated nuclease 9 (CRISPR/Cas9), gut microbiome, and liquid biopsy are powerful tools with the possibility to shift the immunologic landscape and outlook for CRC precise medicine.

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Role of the nervous system in cancer metastasis

Cited by 107 publications

References 156 publications

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment

Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges

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