Role of the Monocyte–Macrophage System in Normal Pregnancy and Preeclampsia

Vishnyakova, Polina; Elchaninov, Andrey; Fatkhudinov, Timur; Сухих, Г. Т.

doi:10.3390/ijms20153695

Cited by 61 publications

(53 citation statements)

References 118 publications

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“…There has been growing evidence of and interest in the possible clinical uses of monocyte subsets analyses by flow cytometry for inflammation [447,448], autoimmune diseases [449], infection [100,[450][451][452][453][454][455][456][457], and cancer [458][459][460]. Monocyte subpopulation analyses are also used in the diagnosis of chronic myelomonocytic leukaemia [458][459][460] and may contribute to the prognostic evaluation of patients' MDS [459,460].…”

Section: Discussionmentioning

confidence: 99%

Standardization of sampling and sample preparation for analysis of human monocyte subsets in peripheral blood

Rundgren

Bruserud

Ryningen

et al. 2018

Journal of Immunological Methods

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Section: Discussionmentioning

confidence: 99%

Standardization of sampling and sample preparation for analysis of human monocyte subsets in peripheral blood

Rundgren

Bruserud

Ryningen

et al. 2018

Journal of Immunological Methods

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“…The expression of CD80 and CD86 in macrophages from RSA patients is higher than that in controls, and this abnormal macrophage subset might also influence the immunosuppressive effects of Tregs (37). Villitis of unknown etiology (VUE), chorioamnionitis-induced spontaneous preterm birth, severe preeclampsia, and HELLP syndrome are related to a shift in the macrophage phenotype from M1 to M2, and this shift is accompanied by a change in the phenotypic markers from CD80/CD86 to CD163/CD206 (38,39). T. gondii infection increases the expression of B7-2 on macrophages (40).…”

Section: B7-1 and B7-2mentioning

confidence: 99%

The Role of B7 Family Molecules in Maternal–Fetal Immunity

2020

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Pregnancy is a complex but well-arranged process, and a healthy fetus requires immune privilege and surveillance in the presence of paternally derived antigens. Maternal and fetal cells interact at the maternal-fetal interface. The upregulation and downregulation of maternal immunity executed by the leukocyte population predominantly depend on the activity of decidual natural killer cells and trophoblasts and are further modulated by a series of duplex signals. The B7 family, which consists of B7-1, B7-2, B7-H1, B7-DC, B7-H2, B7-H3, B7-H4, B7-H5, BTNL2, B7-H6, and B7-H7, is one of the most characterized and widely distributed signaling molecule superfamilies and conducts both stimulatory and inhibitory signals through separate interactions. In particular, the roles of B7-1, B7-2, B7-H1, and their corresponding receptors in the progression of normal pregnancy and some pregnancy complications have been extensively studied. Together with the TCR-MHC complex, B7 and its receptors play a critical role in cell proliferation and cytokine secretion. Depending on this ligand-receptor crosstalk, the balance between the tolerance and rejection of the fetus is perfectly maintained. This review aims to provide an overview of the current knowledge of the B7 family and its functions in regulating maternal-fetal immunity through individual interactions.

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“…The resident macrophages of islets, that under normal conditions can exert homeostatic and regenerative properties can become pro-inflammatory under pathologic conditions such as obesity and/or diabetes. Noteworthily, the in vivo maintenance of macrophages anti-inflammatory phenotype could be achieved by blocking IL-6 signaling or by treatment with IL-4 and IL-10 [67]. However, IL-6 is increased in GDM while IL-4 and IL-10 are in general decreased, thus suggesting that the GDM environment favors macrophages transition to a pro-inflammatory M1 phenotype.…”

Section: Inflammation Underlying Gdm Development and Derived Adverse mentioning

confidence: 99%

Molecular Modelling of Islet β-Cell Adaptation to Inflammation in Pregnancy and Gestational Diabetes Mellitus

Lorenzo

Martín-Montalvo

Vuilleumier

et al. 2019

IJMS

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Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late pregnancy, is currently one of the most common complications affecting pregnancy. The polygenic nature of GDM, together with the interplay between different genetic variants with nutritional and environmental factors has hindered the full understanding of the etiology of this disease. However, an important genetic overlap has been found with type 2 diabetes mellitus (T2DM) and, as in the case of T2DM, most of the identified loci are associated with β-cell function. Early detection of GDM and adequate interventions to control the maternal glycemia are necessary to avoid the adverse outcomes for both the mother and the offspring. The in utero exposure to the diabetic milieu predispose these children for future diseases, among them T2DM, originating a vicious circle implicated in the increased prevalence of both GDM and T2DM. The involvement of inflammatory processes in the development of GDM highlights the importance of pancreatic β-cell factors able to favor the adaptation processes required during gestation, concomitantly with the protection of the islets from an inflammatory milieu. In this regard, two members of the Pax family of transcription factors, PAX4 and PAX8, together with the chromatin remodeler factor HMG20A, have gained great relevance due to their involvement in β-cell mass adaptation together with their anti-inflammatory properties. Mutations in these factors have been associated with GDM, highlighting these as novel candidates for genetic screening analysis in the identification of women at risk of developing GDM.

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Role of the Monocyte–Macrophage System in Normal Pregnancy and Preeclampsia

Cited by 61 publications

References 118 publications

Standardization of sampling and sample preparation for analysis of human monocyte subsets in peripheral blood

Standardization of sampling and sample preparation for analysis of human monocyte subsets in peripheral blood

The Role of B7 Family Molecules in Maternal–Fetal Immunity

Molecular Modelling of Islet β-Cell Adaptation to Inflammation in Pregnancy and Gestational Diabetes Mellitus

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