Role of the medial geniculate body in the production of conditioned reflexes to amplitude-modulated stimuli in rats

Grigor’eva, T. I.; Figurina, I I; Vasil'ev, A. G.

doi:10.1007/bf01186901

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Ablations and lesions of auditory cortex have been shown to interfere with the processing of temporal tasks, such as the order of events (193), discrimination between 10-and 300-Hz trains of noise bursts (277), the detection of AM frequencies below but not above ϳ30 Hz (89), and the perception of periodicity pitch (299), to name a few examples. Studies in patients with primary cortical lesions resulting in "word deafness" also show evidence for deteriorated temporal processing capacities (88).…”

Section: Neurophysiological and Psychological Studies In Humansmentioning

confidence: 99%

Neural Processing of Amplitude-Modulated Sounds

Joris

Schreiner

Rees

2004

Physiological Reviews

842

861

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Amplitude modulation (AM) is a temporal feature of most natural acoustic signals. A long psychophysical tradition has shown that AM is important in a variety of perceptual tasks, over a range of time scales. Technical possibilities in stimulus synthesis have reinvigorated this field and brought the modulation dimension back into focus. We address the question whether specialized neural mechanisms exist to extract AM information, and thus whether consideration of the modulation domain is essential in understanding the neural architecture of the auditory system. The available evidence suggests that this is the case. Peripheral neural structures not only transmit envelope information in the form of neural activity synchronized to the modulation waveform but are often tuned so that they only respond over a limited range of modulation frequencies. Ascending the auditory neuraxis, AM tuning persists but increasingly takes the form of tuning in average firing rate, rather than synchronization, to modulation frequency. There is a decrease in the highest modulation frequencies that influence the neural response, either in average rate or synchronization, as one records at higher and higher levels along the neuraxis. In parallel, there is an increasing tolerance of modulation tuning for other stimulus parameters such as sound pressure level, modulation depth, and type of carrier. At several anatomical levels, consideration of modulation response properties assists the prediction of neural responses to complex natural stimuli. Finally, some evidence exists for a topographic ordering of neurons according to modulation tuning. The picture that emerges is that temporal modulations are a critical stimulus attribute that assists us in the detection, discrimination, identification, parsing, and localization of acoustic sources and that this wide-ranging role is reflected in dedicated physiological properties at different anatomical levels.

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Section: Neurophysiological and Psychological Studies In Humansmentioning

confidence: 99%

Neural Processing of Amplitude-Modulated Sounds

Joris

Schreiner

Rees

2004

Physiological Reviews

842

861

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show abstract

“…Grigor'eva and Vasil'ev (1981) reported that rats with bilateral lesions of auditory cortex had impairments in discriminating modulated from un-modulated tones in a twochoice behavioral discrimination task. They found that rats with cortical lesions could not discriminate between an unmodulated 12 kHz tone and 12 kHz tone modulated at 5 Hz (sinusoidal modulation at 80% depth).…”

Section: Cortical Lesions and The Detection Of Am Soundsmentioning

confidence: 99%

Detection of sinusoidal amplitude modulated sounds: Deficits after bilateral lesions of auditory cortex in the rat

2007

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“…Specifically, such cortical ablation hindered identification of the order of signals in cats [36] and monkeys [37], discrimination between 10-and 300-Hz (corresponding to 3-to 100-ms intervals) trains of noise bursts in monkeys [38], detection of amplitude-modulation (AM) rate below but not above ~30 Hz (≥ 33-ms intervals) in rats [39], and detection of temporal gaps between noise in rats [40] and ferrets [41]. In general, such cortical ablation did not produce profound audiometric hearing loss [42][43][44].…”

Section: Cortical Ablation Studies On Animalsmentioning

confidence: 99%

“…Constraints on the shorter limiting pulse-interval for stimulus locking: It is noteworthy that the shorter limiting pulse-interval for stimulus locking (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) ms; open arrow, Figure 11) is akin to the transition point from the GABA A -receptor mediated IPSP (broken blue curve, left [adopted from Figure 8B]) and the NMDA-receptormediated EPSP (broken red curve, right). This value is compatible with the neurophysiology data on un-anesthetized animals [1,[61][62][63][64][65] but rather shorter than the data (40-200 ms) on pentbarbiturateanesthetized animals [75][76][77].…”

Section: Ramification Of the Full-version Modelmentioning

confidence: 99%

Neural Mechanisms of Fine-Grained Temporal Processing in Audition

Sakai¹

2012

Otolaryngology

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Role of the medial geniculate body in the production of conditioned reflexes to amplitude-modulated stimuli in rats

Cited by 4 publications

References 4 publications

Neural Processing of Amplitude-Modulated Sounds

Neural Processing of Amplitude-Modulated Sounds

Detection of sinusoidal amplitude modulated sounds: Deficits after bilateral lesions of auditory cortex in the rat

Neural Mechanisms of Fine-Grained Temporal Processing in Audition

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