Role of the Liver in the Conjugation of Histamine in Intact Animals

Livingston, R. H.; Code, Charles F.

doi:10.1152/ajplegacy.1955.181.2.428

Cited by 17 publications

(4 citation statements)

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“…There was no evidence of acetylation of the injected histamine. This is in agreement with Livingston & Code (1955), who did not find any increase in the excretion of conjugated histamine in urine during an intraportal infusion of histamine in dogs.…”

Section: Discussionsupporting

confidence: 93%

METABOLISM OF [¹⁴C]‐HISTAMINE IN HEART‐LUNG‐LIVER PREPARATIONS OF CATS

Lilja¹,

Lindell²

1961

British Journal of Pharmacology and Chemotherapy

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The metabolism of injected ["C]-histamine was studied in heart-lung-liver preparations and heart-lung preparations from cats. When the liver was included in the circulation the injected histamine was rapidly eliminated from the blood, some of its metabolites appearing in the blood within 2 min after the injection. More than 70% of the injected histamine was metabolized to 1-methylimidazol-4-ylacetic acid. In the heart-lung preparations ["C]-histamine disappeared much more slowly from the blood and the major metabolite was 4-(2-aminoethyl)-1-methylimidazole (methylhistamine). Less than 4% of the injected "4C was recovered in the form of imidazol-4(or 5)-ylacetic acid. In none of the experiments was there any measurable formation of acetylhistamine.

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Section: Discussionsupporting

confidence: 93%

METABOLISM OF [¹⁴C]‐HISTAMINE IN HEART‐LUNG‐LIVER PREPARATIONS OF CATS

Lilja¹,

Lindell²

1961

British Journal of Pharmacology and Chemotherapy

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“…None the less, it is probable that some intestinal absorption takes place since histamine given orally or administered into isolated segments of the intestine raises the concentration of free histamine in the blood (Duncan & Waton, 1968) and urine (e.g. Millican, Rosenthal & Tabor, 1949;Livingston & Code, 1955;Irvine, Duthie, Ritchie & Waton, 1959). In sheep also, urinary excretion of free histamine increases following oral administration (Sjaastad, 1967 d).…”

Section: Absorption and Catabolism Of Histaminementioning

confidence: 99%

Absorption and catabolism of histamine in sheep

Kay¹,

Sjaastad²

1974

The Journal of Physiology

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4. When jejunal loops isolated between two pairs of re-entrant cannulas were perfused with 0-9 % NaCl solution containing histamine a considerable fraction of the histamine was absorbed from the loops. 5. When [14C]histamine and 200 mg histamine diphosphate were administered into the rumen an average of 9 % of the radioactivity appeared in the urine. When histamine was given into the abomasum the corresponding figure in a single experiment was 25 %. 6. Between 11 and 34 % of the radioactivity administered into the rumen as [14C]histamine was exhaled as 14CO2 Most of the 14CO2 seemed to stem from metabolism of [14C]histamine in the ruminoreticulum whereas the contribution of the intestines to 14CO2 was very small. 7. When [3H]histamine was administered into the rumen most of the radioactivity in the urine a few days after administration was in the form of tritiated water. The formation of 3H20 is probably a result of histamine metabolism in the fore-stomach, analogous to the formation of 14CO2.

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“…At that time Livingstone and Code [13] showed in dogs that only small amounts of a huge oral load of histamine was found in the urine suggesting that uptake of histamine from the gut is small if it at all exists. The ingested dose of histamine was so great that already a fraction of this would have serious circulatory and respiratory effects.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of diamine oxidase promotes uptake of putrescine from rat small intestine

1996

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In blood from the portal vein of anaesthetized rats the levels of histamine and putrescine were 2-3-fold lower compared to arterial blood. Putrescine concentration was increased severalfold and the difference between portal and arterial blood abolished in animals pretreated with the specific diamine oxidase inhibitor aminoguanidine. Histamine concentration was 40% lower in portal compared to arterial blood in animals treated with the mast cell degranulator compound 48/80. In animals pretreated with aminoguanidine, compound 48/80 enhanced the level of histamine and no difference was observed between arterial and portal blood. The amounts of intravenously injected [14C]-labeled histamine was about 15% lower in portal compared to arterial blood. The uptake of [14C]-putrescine from the small intestine was estimated. In urine from animals pretreated with aminoguanidine the concentration of [14C]-putrescine was more than 40-times higher than in control animals corresponding to a calculated uptake of about 7% in aminoguanidine treated animals. Our results suggest that intestinal diamine oxidase clears the blood from diamines and prevents luminal uptake of putrescine.

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Role of the Liver in the Conjugation of Histamine in Intact Animals

Cited by 17 publications

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METABOLISM OF [¹⁴C]‐HISTAMINE IN HEART‐LUNG‐LIVER PREPARATIONS OF CATS

METABOLISM OF [¹⁴C]‐HISTAMINE IN HEART‐LUNG‐LIVER PREPARATIONS OF CATS

Absorption and catabolism of histamine in sheep

Inhibition of diamine oxidase promotes uptake of putrescine from rat small intestine

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Role of the Liver in the Conjugation of Histamine in Intact Animals

Cited by 17 publications

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METABOLISM OF [14C]‐HISTAMINE IN HEART‐LUNG‐LIVER PREPARATIONS OF CATS

METABOLISM OF [14C]‐HISTAMINE IN HEART‐LUNG‐LIVER PREPARATIONS OF CATS

Absorption and catabolism of histamine in sheep

Inhibition of diamine oxidase promotes uptake of putrescine from rat small intestine

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METABOLISM OF [¹⁴C]‐HISTAMINE IN HEART‐LUNG‐LIVER PREPARATIONS OF CATS

METABOLISM OF [¹⁴C]‐HISTAMINE IN HEART‐LUNG‐LIVER PREPARATIONS OF CATS