Abstract:Aldehyde dehydrogenase 2 (ALDH2) is important for the detoxification of 4‐hydroxy‐2‐nonenal (HNE), a toxic aldehyde produced by oxidative stress‐induced lipid peroxidation, which can form protein adducts and alter cell function. Tolerance to nitrates such as nitroglycerin (GTN) is associated with oxidative stress, inactivation of ALDH2, and decreased GTN‐induced cGMP accumulation and vasodilation. We hypothesized that GTN‐induced inactivation of ALDH2 results in increased HNE adduct formation of key proteins, … Show more
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