Role of the JAK/STAT Pathway in the Regulation of Interleukin-8 Transcription by Oxidized Phospholipids in Vitro and in Atherosclerosis in Vivo

Gharavi, Nima M.; Alva, Jackelyn A.; Mouillesseaux, Kevin P.; Lai, Chi; Yeh, Michael W.; Yeung, Winnie; Johnson, Jaclyn P; Szeto, Wan Lam; Li, Hong; Fishbein, Michael; Wei, Lai; Pfeffer, Lawrence M.; Berliner, Judith A.

doi:10.1074/jbc.m704267200

Cited by 134 publications

(127 citation statements)

References 44 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, most of the pathways discussed below are also activated by PEIPC, the most active pro-inflammatory phospholipid in Ox-PAPC. The rapid activation of IL-8 transcription was demonstrated to be activated by a c-Src/JAK2/STAT3 pathway 27 , which is turned on within seconds following Ox-PAPC treatment and returns to baseline levels within 4-6 hours. This pathway directly regulates IL-8 transcription through binding to a novel gamma-interferon activation sequence (GAS) element in the IL-8 promoter.…”

Section: Chemokine Expressionmentioning

confidence: 99%

Endothelial cell regulation by phospholipid oxidation products

Berliner

Gharavi

2008

Free Radical Biology and Medicine

Self Cite

View full text Add to dashboard Cite

Oxidized phospholipids accumulate in atherosclerotic lesions, on lipoproteins, in other states of chronic inflammation, on apoptotic cells, necrotic cells and cells exposed to oxidative stress. These lipids regulate the transcription of over 1000 gene, regulating many endothelial functions, by activating several different cell surface receptors and multiple signaling pathways. These lipids also have important effects not involving transcription that regulate cell junctions and leukocyte binding. Thus these lipids are potent regulators of endothelial cell function with broad effects comparable in extent but differing from those of cytokines.

show abstract

Section: Chemokine Expressionmentioning

confidence: 99%

Endothelial cell regulation by phospholipid oxidation products

Berliner

Gharavi

2008

Free Radical Biology and Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Hence, reduction of TGF-, PDGF in lung tissues and TNF- in BALF is possibly seen as a result of the reduction of the infiltration of inflammatory cells and as a result of the decreased release by these inflammatory cells. It is also possibly seen as a result of the down-regulation of the STAT1 signaling pathway, which has been shown to be involved in cytokine effects on immunity and inflammation (9)(10)(11)(12). Accordingly, the decreased inflammatory mediators, in turn, decreased infiltration of inflammatory cells.…”

Section: Figure 4 Rt-pcr Results Of Type I Collagen (A and C) And mentioning

confidence: 99%

“…The first discovered STAT protein was STAT1, which correlated with immunity and inflammation. Several studies showed that STAT1 correlated with the occurrence and development of inflammatory and immune diseases (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Aerosolized STAT1 Antisense Oligodeoxynucleotides on Rat Pulmonary Fibrosis

et al. 2009

View full text Add to dashboard Cite

“…In contrast, in many diseases, the STAT proteins are persistently activated. Many studies supported that abnormal STAT activation was involved in many diseases such as tumors, inflammatory diseases and so on (7,8).…”

Section: Introductionmentioning

confidence: 97%

“…The first discovered STAT protein was STAT1, which correlated with the occurrence and development of inflammatory and immune diseases (7)(8)(9). In previous study, we found that there was abnormal STAT1 activation in AMs of rats with bleomycin (BLM)-induced IPF based on nuclear transportation of STAT1, which led to upregulation of STAT1-dependent immune response gene intercellular adhesion molecule (ICAM-1) expression.…”

Section: Introductionmentioning

confidence: 99%