Role of the IL-11/STAT3 signaling pathway in human chronic atrophic gastritis and gastric cancer

Wang, D Q; Ding, Xiaoyu; Yin, Shi; Mao, Yanfang

doi:10.4238/gmr.15027358

Cited by 12 publications

(11 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that the IL-11 was one of the top ten down-regulated genes in the down-regulated gene subgroup. Given that previous studies [ 26 , 27 ] have reported that IL-11/STAT3 can regulate metastasis, we reasoned that KRT8 may promote metastatic cell survival through IL-11/STAT3 signaling activation. To further validate the effects of KRT8 on IL-11/STAT3 signaling in vitro , we measured IL-11 mRNA and protein levels in different ACHN, Caki-1, and 786-O cell clones and found that KRT8 knockdown significantly decreased IL-11 mRNA and protein levels in ACHN-SH and Caki-1-SH cells.…”

Section: Resultsmentioning

confidence: 99%

KRT8 upregulation promotes tumor metastasis and is predictive of a poor prognosis in clear cell renal cell carcinoma

Tan

Jiang

et al. 2017

Oncotarget

View full text Add to dashboard Cite

Keratin 8 (KRT8) plays an essential role in the development and metastasis of multiple human cancers. However, its role in clear cell renal cell carcinoma (ccRCC) remains unexplored. Here, we investigated the expression pattern, clinical significance, and function of KRT8 in ccRCC. KRT8 mRNA and protein levels were determined in two large cohorts using quantitative real-time polymerase chain reaction (qRT-PCR) and tissue microarray (TMA) immunohistochemistry (IHC), respectively. We found that KRT8 expression was upregulated in ccRCC and vein tumor thrombi (VTTs). KRT8 overexpression in ccRCC was significantly correlated with aggressive characteristics and was predictive of a poor prognosis in ccRCC patients. Moreover, KRT8 overexpression in renal cancer cell lines promoted cell migration and invasion. In contrast, KRT8 knockdown suppressed ccRCC metastasis both in vitro and in vivo. In addition, our findings showed that KRT8 promoted ccRCC metastasis by increasing IL-11 expression, causing IL-11 autocrine induction, and triggering STAT3 signaling. Overall, this study established the significance of KRT8-IL-11 axis activation in aggressive ccRCC and defined a novel critical signaling mechanism that drives human ccRCC invasion and metastasis.

show abstract

Section: Resultsmentioning

confidence: 99%

KRT8 upregulation promotes tumor metastasis and is predictive of a poor prognosis in clear cell renal cell carcinoma

Tan

Jiang

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…The formation of tumor microenvironment could lead to the infiltration of immunosuppressive cells such as myeloid derived suppressor cell, regulatory T cell and tumor associated macrophage, upregulation of a series of proinflammatory factors, and accumulation of a large number of inflammatory cytokines such as IL-6, IL-11, TGF- β , and MMP. These cytokines could promote the immune escape and metastasis of tumors by STAT3, NF- κ B signal pathway, and so on [23–27]. …”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Preoperative Albumin and Globulin Ratio in Patients with Gastric Cancer Undergoing Treatment

Mao

Wei

Sheng

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

Background. The pretreatment albumin and globulin ratio (AGR) was an inflammation-associated factor which was related to the overall survival in various malignancies. The aim of this study was to evaluate the prognostic value of AGR in patients with gastric cancer. Method. This retrospective study included 862 cases pathologically diagnosed with gastric cancer. All patients were randomly divided into the testing group (431 cases) and validation group (431 cases). The relationships of AGR with clinicopathologic characteristics and prognosis were analyzed by Kaplan-Meier and Cox regression methods. Results. In the testing group, the median overall survival was 26.90 months and the cutoff value of AGR was 1.50 based on R language. Kaplan-Meier analysis showed that lower AGR was correlated with poorer overall survival. Multivariate analysis demonstrated that AGR was an independent prognostic factor for overall survival (HR: 0.584, 95% CI = 0.351–0.973, and p = 0.039). In the validation group, the median overall survival was 24.10 months. Lower AGR (≤1.50) also had a significantly poorer overall survival by Kaplan-Meier analysis. According to multivariate analysis, the AGR was also confirmed to be an independent prognostic factor for overall survival (HR: 0.578, 95% CI = 0.373–0.897, and p = 0.015). Conclusions. Our study suggested that the pretreatment AGR could be a prognostic biomarker for overall survival in patients with gastric cancer.

show abstract

“…High levels of IL-6, IL-10, IL-11, IL-32, and chemokine C-C motif ligands (CCL)7 and CCL21 in circulation, high expression of CXC chemokine receptor 4, chemokine C-C motif receptor 3 (CCR3), CCR4, CCR5, CCR7 and orphan nuclear receptor 4A2 in tumors were found to be associated with disease progression and an unfavorable prognosis in gastric cancer [72,73]. IL-6 and TNF are expressed at high levels in human gastric cancer samples.…”

Section: Pro-inflammatory Mediators and Growth Factors In The Gastmentioning

confidence: 99%

NF‐κB Signaling in Gastric Cancer

Sokolova

Naumann

2017

Toxins

175

122

View full text Add to dashboard Cite

Gastric cancer is a leading cause of cancer death worldwide. Diet, obesity, smoking and chronic infections, especially with Helicobacter pylori, contribute to stomach cancer development. H. pylori possesses a variety of virulence factors including encoded factors from the cytotoxin-associated gene pathogenicity island (cagPAI) or vacuolating cytotoxin A (VacA). Most of the cagPAI-encoded products form a type 4 secretion system (T4SS), a pilus-like macromolecular transporter, which translocates CagA into the cytoplasm of the host cell. Only H. pylori strains carrying the cagPAI induce the transcription factor NF-κB, but CagA and VacA are dispensable for direct NF-κB activation. NF-κB-driven gene products include cytokines/chemokines, growth factors, anti-apoptotic factors, angiogenesis regulators and metalloproteinases. Many of the genes transcribed by NF-κB promote gastric carcinogenesis. Since it has been shown that chemotherapy-caused cellular stress could elicit activation of the survival factor NF-κB, which leads to acquisition of chemoresistance, the NF-κB system is recommended for therapeutic targeting. Research is motivated for further search of predisposing conditions, diagnostic markers and efficient drugs to improve significantly the overall survival of patients. In this review, we provide an overview about mechanisms and consequences of NF-κB activation in gastric mucosa in order to understand the role of NF-κB in gastric carcinogenesis.

show abstract

Role of the IL-11/STAT3 signaling pathway in human chronic atrophic gastritis and gastric cancer

Cited by 12 publications

References 23 publications

KRT8 upregulation promotes tumor metastasis and is predictive of a poor prognosis in clear cell renal cell carcinoma

KRT8 upregulation promotes tumor metastasis and is predictive of a poor prognosis in clear cell renal cell carcinoma

Clinical Significance of Preoperative Albumin and Globulin Ratio in Patients with Gastric Cancer Undergoing Treatment

NF‐κB Signaling in Gastric Cancer

Contact Info

Product

Resources

About