Role of the H-2 Complex in Preimplantation Mouse Embryo Development

Goldbard, Simon; Verbanac, Kathryn M.; Warner, Carol M.

doi:10.1095/biolreprod26.4.591

Cited by 56 publications

(17 citation statements)

References 13 publications

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“…At 96 h the mean number of normal blastocysts was 8.9 in Californians and 8.2 in New Zealands. These means are about equal to the number of young born (Torrbs et al, 1987 Golbard et al (1982a, b …”

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confidence: 99%

Early stages of embryonic development in two rabbit genotypes

Torrès¹,

Hulot²,

Sevellec³

1987

Reprod. Nutr. Dévelop.

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confidence: 99%

Early stages of embryonic development in two rabbit genotypes

Torrès¹,

Hulot²,

Sevellec³

1987

Reprod. Nutr. Dévelop.

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“…Many inbred strains and mutants exhibit impaired fertility and low embryonic viability that affect this effort. For example, in the mouse and rat, genotype is reported to influence ovulation rate in response to superovulatory treatments with gonadotropins (Bindon and Pennycuik 1974;Dorsch and Hedrich 1998;Durrant et al 1980;Schmidt et al 1989;, the ability of preimplantation mouse embryos to develop in vitro (Chatot et al 1990;Dandekar and Glass 1987;Pomp and Eisen, 1991;Scott and Whittingham, 1996), and the rate of development and quality grades of preimplantation embryos (Al-Shorepy et al 1992;Durrant et al 1980;Goldbard et al 1982;Wu et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting the Efficiency of Embryo Cryopreservation and Rederivation of Rat and Mouse Models

Rall

Schmidt²,

Lin³

et al. 2000

ILAR Journal

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The efficiency of embryo banking for rat and mouse models of human disease and normal biological processes depends on the ease of obtaining embryos. Authors report on the effect of genotype on embryo production and rederivation. In an effort to establish banks of cryopreserved embryos, they provide two databases for comparing banking efficiency: one that contains the embryo collection results from approximately 11,000 rat embryo donors (111 models) and another that contains the embryo collection results from 4,023 mouse embryo donors (57 induced mutant models). The genotype of donor females affected the efficiency of embryo collection in two ways. First, the proportion of females yielding embryos varied markedly among genotypes (rats: 16-100 %, mean =71 %; mice: 24-95 %, mean =65 %). Second, the mean number of embryos recovered from females yielding embryos varied considerably (rats: 4-10.6, mean =7.8; mice 5.3-32.2, mean =13.7). Genotype also affected the efficiency of rederivation of banked rat and mouse embryos models by embryo transfer. For rats, thawed embryos (n =684) from 33 genotypes were transferred into 66 recipient females (pregnancy rate, 78 %). The average rate of developing live newborns for individual rat genotypes was 30 % with a range of 10 to 58 %. For mice, thawed embryos (n =2,064) from 59 genotypes were transferred into 119 pseudopregnant females (pregnancy rate: 76 %). The average rate of development of individual mouse genotypes was 33 % with a range of 11 to 53 %. This analysis demonstrates that genotype is an important consideration when planning embryo banking programs.

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“…Two phenotypes of the Ped gene, fast and slow, have been defined. Ped fast preimplantation embryos develop at a significantly faster rate, both in vivo and in vitro, compared with Ped slow embryos (13,16,17). HLA-G is suggested to be the human functional homologue of the mouse Qa-2 protein (2,8,9).…”

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Down-regulation of HLA-G attenuates cleavage rate in human triploid embryos

Han

Sun

Haines

et al. 2009

Fertility and Sterility

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Introduction: HLA-G is a major histocompatibility complex (MHC), class Ib molecule that is selectively expressed at the fetal-maternal interface. It is thought to play a role in protecting the fetus from the maternal immune response. Interestingly, the preimplantation embryo development (Ped) gene product Qa-2 is also a mouse MHC class Ib protein that affects cleavage and division of preimplantation mouse embryos and subsequent embryonic survival. Data from many human in vitro fertilization (IVF) clinics suggest that the mouse Ped phenomenon also exists in human because embryos fertilized at the same time have different cleavage rates and consequently different IVF outcomes. As HLA-G is expressed in human early embryos, it is highly regarded as the functional homologue of Qa-2. Whether HLA-G expression is correlated with the cleavage rate of human embryos has great potential clinical value. Methods: In this study, 45 human early abnormal fertilized embryos (3 PN) from patients undergoing in vitro fertilization were used to test the effects of HLA-G knock-down via infection with adenovirus carrying its specific siRNA on the cleavage rate in a 2-day culture period. One-way ANOVA, Post hoc and Chi-square were used to compare groups. A p-value smaller than 0.05 was considered statistically significant. Results: Knocking-down HLA-G in human pre-implantation stage embryos resulted in a higher cell arrest rate and a slower cleavage rate. Conclusion:The results from the present study suggested that HLA-G might play an important role in early human embryo development.

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Role of the H-2 Complex in Preimplantation Mouse Embryo Development

Cited by 56 publications

References 13 publications

Early stages of embryonic development in two rabbit genotypes

Early stages of embryonic development in two rabbit genotypes

Factors Affecting the Efficiency of Embryo Cryopreservation and Rederivation of Rat and Mouse Models

Down-regulation of HLA-G attenuates cleavage rate in human triploid embryos

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