Role of the GRP/GRPR System in Regulating Brain Functions

Zhao, Tiantian; Chen, Aiwen; Dai, Danqing; Li, Zhen; Gao, Xiao-Fei; Xiong, Lize

doi:10.1021/acschemneuro.3c00392

“…In addition, in the teleosts closely related to hadal snail sh, there are usually two copies of grpr encoding the gastrin-releasing peptide receptor; we noticed that in hadal snail sh one of them is absent and the other is barely expressed in brain (Figure 4C), whereas a previous study found that the grpr gene in the mouse suprachiasmatic nucleus (SCN) did not uctuate signi cantly during a 24-hour light/dark cycle and had a relatively stable expression (Pembroke, Babbs, Davies, Ponting, & Oliver, 2015) (Figure 4-gure supplements 1). It has been reported that grpr de cient mice, while exhibiting normal circadian rhythms, show signi cantly increased locomotor activity in dark conditions (Wada et al, 1997;Zhao et al, 2023). We might therefore speculate that the absence of that gene might in some way bene t the activity of hadal snail sh under complete darkness.…”

Section: Circadian Rhythm Decoupled From Sunlight and Dark Adaptationmentioning

confidence: 85%

Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates

Xu,

Zhu,

Gao

et al. 2023

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As the deepest vertebrate in the ocean, the hadal snailfish (Pseudoliparis swirei), which lives at a depth of 6,000~8,000m, is a representative case for studying adaptation to extreme environments. Despite some preliminary studies on this species in recent years, including their loss of pigmentation, visual and skeletal calcification genes, and the role of TMAO in adaptation to high-hydrostatic pressure, it is still unknown how they evolved and why they are among the few vertebrate species that have successfully adapted to the deep sea environment. Using genomic data from different trenches, we found that the hadal snailfish may have entered and fully adapted to such extreme environments only in the last few million years. Meanwhile, phylogenetic relationships show that they spread into different trenches in the Pacific Ocean within a million years. Comparative genomic analysis has also revealed that the genes associated with perception, circadian rhythms, and metabolism have been extensively modified in the hadal snailfish to adapt to its unique environment. More importantly, the tandem duplication of a gene encoding ferritin significantly increased their tolerance to reactive oxygen species, which may be one of the important factors in their adaptation to high-hydrostatic pressure.

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Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates

Xu

¹

,

Zhu

²

,

Gao

³

et al. 2023

eLife

1

0

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As the deepest vertebrate in the ocean, the hadal snailfish (Pseudoliparis swirei), which lives at a depth of 6,000~8,000m, is a representative case for studying adaptation to extreme environments. Despite some preliminary studies on this species in recent years, including their loss of pigmentation, visual and skeletal calcification genes, and the role of TMAO in adaptation to high-hydrostatic pressure, it is still unknown how they evolved and why they are among the few vertebrate species that have successfully adapted to the deep sea environment. Using genomic data from different trenches, we found that the hadal snailfish may have entered and fully adapted to such extreme environments only in the last few million years. Meanwhile, phylogenetic relationships show that they spread into different trenches in the Pacific Ocean within a million years. Comparative genomic analysis has also revealed that the genes associated with perception, circadian rhythms, and metabolism have been extensively modified in the hadal snailfish to adapt to its unique environment. More importantly, the tandem duplication of a gene encoding ferritin significantly increased their tolerance to reactive oxygen species, which may be one of the important factors in their adaptation to high-hydrostatic pressure.

show abstract

Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates

Xu,

Zhu,

Gao

et al. 2023

Preprint

0

View full text Add to dashboard Cite

As the deepest vertebrate in the ocean, the hadal snailfish (Pseudoliparis swirei), which lives at a depth of 6,000~8,000m, is a representative case for studying adaptation to extreme environments. Despite some preliminary studies on this species in recent years, including their loss of pigmentation, visual and skeletal calcification genes, and the role of TMAO in adaptation to high-hydrostatic pressure, it is still unknown how they evolved and why they are among the few vertebrate species that have successfully adapted to the deep sea environment. Using genomic data from different trenches, we found that the hadal snailfish may have entered and fully adapted to such extreme environments only in the last few million years. Meanwhile, phylogenetic relationships show that they spread into different trenches in the Pacific Ocean within a million years. Comparative genomic analysis has also revealed that the genes associated with perception, circadian rhythms, and metabolism have been extensively modified in the hadal snailfish to adapt to its unique environment. More importantly, the tandem duplication of a gene encoding ferritin significantly increased their tolerance to reactive oxygen species, which may be one of the important factors in their adaptation to high-hydrostatic pressure.

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Role of the GRP/GRPR System in Regulating Brain Functions

Cited by 4 publications

References 90 publications

Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates

Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates

Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates

Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates

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