Role of the golgi apparatus in cellular pathology

Morré, Dorothy M.

doi:10.1002/jemt.1060170207

Cited by 8 publications

(4 citation statements)

References 126 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These changes could be due to an increased secretory activity of thyroid follicular cells after treatment with OeþPr, although the Golgi com-plex has also been observed to decrease when secretion is stimulated (Morre, 1991). In contrast to these findings in pigs, in rats neonataly treated with estradiol alone, ultrastructural features of thyroid follicular cells showed suggestive signs of decreased ability for biosynthesis and reabsorbtion of thyroglobuline: the cells had decreased number of polysomes, cysternoid and less developed GER, reduced Golgi complex, and rare microvilli (Sekulić, 1988).…”

Section: The Effect Of Oeþpr On Thyroid Glandmentioning

confidence: 99%

Effect of estradiol and progesterone on thyroid gland in pigs: A histochemical, stereological, and ultrastructural study

Sekulić¹,

Šošić‐Jurjević²,

Filipović³

et al. 2006

Microscopy Res & Technique

View full text Add to dashboard Cite

The cellular and subcellular organization of thyroid follicular cells in peripubertal (6-month-old) male pigs treated with estradiol-dipropionate (Oe) plus progesterone (Pr) in combination on the first postnatal day was studied. A stereological method was used for morphometric determinations of the relative volume densities of the follicular epithelium, colloid and interstitium, and for establishing the epithelial height and index of activation rate. Statistically significant differences of the examined parameters between the control and Oe+Pr -treated groups were determined by Student's t-test. The subcellular organization of thyroid follicular cells was studied using transmission electron microscopy (TEM). When compared with the control group, in the Oe+Pr -treated pigs, thyroid follicles possessed a noticeably higher follicular epithelium when compared with the control animals. The observed changes were quantified and comparison between the experimental groups showed that the height, volume density of follicular epithelium, and index of activation rate were significantly (P < 0.05) increased, whereas the relative volume density of the colloid was significantly (P < 0.05) decreased. At the subcellular level the thyroid follicular cells of Oe+Pr -treated pigs were characterized by increased number of polysomes and dense bodies and extensive endoplasmatic reticulum. It was concluded that a single neonatal treatment with female gonadal steroids exerted a prolonged effect on the pig's thyroid, characterized by increased biosynthesis and reabsorption of the colloid by the follicular cells.

show abstract

Section: The Effect Of Oeþpr On Thyroid Glandmentioning

confidence: 99%

Effect of estradiol and progesterone on thyroid gland in pigs: A histochemical, stereological, and ultrastructural study

Sekulić¹,

Šošić‐Jurjević²,

Filipović³

et al. 2006

Microscopy Res & Technique

View full text Add to dashboard Cite

show abstract

“…The putative localization of the GalNAc-transferases to the Golgi apparatus was further corroborated by simultaneous staining with a nucleus specific stain using conventional or confocal microscopy ( Figure 6). Morphological changes of the Golgi apparatus are associated with pathological changes such as hypertrophy, atrophy, dilation, or collapse of Golgi elements (Morre, 1991).…”

Section: Subcellular Localization Of Galnac-transferasesmentioning

confidence: 99%

Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family

Mandel¹,

et al. 1999

View full text Add to dashboard Cite

Mucin-type O-glycosylation is initiated by a large family of UDP-GalNAc: polypeptide N-acetyl-galactosaminyltransferases (GalNAc-transferases). Individual GalNAc-transferases appear to have different functions and Northern analysis indicates that they are differently expressed in different organs. This suggests that O-glycosylation may vary with the repertoire of GalNAc-transferases expressed in a given cell. In order to study the repertoire of GalNAc-transferases in situ in tissues and changes in tumors, we have generated a panel of monoclonal antibodies (MAbs) with well defined specificity for human GalNAc-T1, -T2, and -T3. Application of this panel of novel antibodies revealed that GalNAc-transferases are differentially expressed in different cell lines, in spermatozoa, and in oral mucosa and carcinomas. For example, GalNAc-T1 and -T2 but not -T3 were highly expressed in WI38 cells, and GalNAc-T3 but not GalNAc-T1 or -T2 was expressed in spermatozoa. The expression patterns in normal oral mucosa were found to vary with cell differentiation, and for GalNAc-T2 and -T3 this was reflected in oral squamous cell carcinomas. The expression pattern of GalNAc-T1 was on the other hand changed in tumors to either total loss or expression in cytological poorly differentiated tumor cells, where the normal undifferentiated cells lacked expression. These results demonstrate that the repertoire of GalNActransferases is different in different cell types and vary with cellular differentiation, and malignant transformation. The implication of this is not yet fully understood, but it suggests that specific changes in sites of O-glycosylation of proteins may occur as a result of changes in the repertoire of GalNActransferases.

show abstract

“…COP I recycles proteins from the cis–Golgi apparatus to the ER while COP II selectively transports synthesized proteins from the ER to the Golgi apparatus [ 14 ]. The major enzymes present in the Golgi matrix have been largely elucidated and arranged in an ordered manner as a series of steps where the cargo is passed from the cis–Golgi to the media–Golgi and then to the trans–Golgi ( Figure 2 ) [ 2 , 3 , 15 , 16 , 17 ]. Regularly arranged enzymes require metal ions to maintain the structure and function of the Golgi apparatus in order for it to be the Golgi apparatus [ 18 ].…”

Section: The Role Of the Golgi Apparatusmentioning

confidence: 99%

Emerging Evidence of Golgi Stress Signaling for Neuropathies

Shirai,

Yamauchi

2024

Neurology International

View full text Add to dashboard Cite

The Golgi apparatus is an intracellular organelle that modifies cargo, which is transported extracellularly through the nucleus, endoplasmic reticulum, and plasma membrane in order. First, the general function of the Golgi is reviewed and, then, Golgi stress signaling is discussed. In addition to the six main Golgi signaling pathways, two pathways that have been increasingly reported in recent years are described in this review. The focus then shifts to neurological disorders, examining Golgi stress reported in major neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. The review also encompasses findings related to other diseases, including hypomyelinating leukodystrophy, frontotemporal spectrum disorder/amyotrophic lateral sclerosis, microcephaly, Wilson’s disease, and prion disease. Most of these neurological disorders cause Golgi fragmentation and Golgi stress. As a result, strong signals may act to induce apoptosis.

show abstract

Role of the golgi apparatus in cellular pathology

Cited by 8 publications

References 126 publications

Effect of estradiol and progesterone on thyroid gland in pigs: A histochemical, stereological, and ultrastructural study

Effect of estradiol and progesterone on thyroid gland in pigs: A histochemical, stereological, and ultrastructural study

Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family

Emerging Evidence of Golgi Stress Signaling for Neuropathies

Contact Info

Product

Resources

About