Role of the epidermis and other epithelia in wound healing: Selected concepts

Lambert, W. Clark; Cohen, Philip; Lambert, Muriel W.

doi:10.1016/0738-081x(84)90024-5

Cited by 8 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rittié [22] described this phenomenon by the fact that “no outgrowth has to migrate farther than half the distance that separates two adnexal structures before meeting another outgrowth moving in the opposite direction.” With regard to human partial thickness wounds, cells have to cover approximately 500 µm of distance and complete epithelialization normally within 8-10 days [23]. The resurfacing of an epidermal wound by migrating keratinocytes was initially described by the term of leapfrogging cells that progressively fall over each other and onto the wound bed without certain migrational activity [25,26]. Other authors depicted leader cells or even entire cell rows that drag others with them to crawl over the wound [27,28,29,30].…”

Section: Epithelialization In Skin Wound Healingmentioning

confidence: 99%

Skin Wound Healing: An Update on the Current Knowledge and Concepts

Sorg

Tilkorn²,

Hager³

et al. 2016

Eur Surg Res

900

691

View full text Add to dashboard Cite

Background: The integrity of healthy skin plays a crucial role in maintaining physiological homeostasis of the human body. The skin is the largest organ system of the body. As such, it plays pivotal roles in the protection against mechanical forces and infections, fluid imbalance, and thermal dysregulation. At the same time, it allows for flexibility to enable joint function in some areas of the body and more rigid fixation to hinder shifting of the palm or foot sole. Many instances lead to inadequate wound healing which necessitates medical intervention. Chronic conditions such as diabetes mellitus or peripheral vascular disease can lead to impaired wound healing. Acute trauma such as degloving or large-scale thermal injuries are followed by a loss of skin organ function rendering the organism vulnerable to infections, thermal dysregulation, and fluid loss. Methods: For this update article, we have reviewed the actual literature on skin wound healing purposes focusing on the main phases of wound healing, i.e., inflammation, proliferation, epithelialization, angiogenesis, remodeling, and scarring. Results: The reader will get briefed on new insights and up-to-date concepts in skin wound healing. The macrophage as a key player in the inflammatory phase will be highlighted. During the epithelialization process, we will present the different concepts of how the wound will get closed, e.g., leapfrogging, lamellipodial crawling, shuffling, and the stem cell niche. The neovascularization represents an essential component in wound healing due to its fundamental impact from the very beginning after skin injury until the end of the wound remodeling. Here, the distinct pattern of the neovascularization process and the special new functions of the pericyte will be underscored. At the end, this update will present 3 topics of high interest in skin wound healing issues, dealing with scarring, tissue engineering, and plasma application. Conclusion: Although wound healing mechanisms and specific cell functions in wound repair have been delineated in part, many underlying pathophysiological processes are still unknown. The purpose of the following update on skin wound healing is to focus on the different phases and to brief the reader on the current knowledge and new insights. Skin wound healing is a complex process, which is dependent on many cell types and mediators interacting in a highly sophisticated temporal sequence. Although some interactions during the healing process are crucial, redundancy is high and other cells or mediators can adopt functions or signaling without major complications.

show abstract

Section: Epithelialization In Skin Wound Healingmentioning

confidence: 99%

Skin Wound Healing: An Update on the Current Knowledge and Concepts

Sorg

Tilkorn²,

Hager³

et al. 2016

Eur Surg Res

900

691

View full text Add to dashboard Cite

show abstract

“…The tensile stretch values are comparable to the values obtained by Ankersen et al . who, on the basis of tensile tests, showed the similarity of rat skin to human skin. When skin is extremely stretched, collagen fibers immediately arrange themselves parallel to each other, leading to an increase in friction to prevent further movement.…”

Section: Discussionmentioning

confidence: 99%

Combination of Er:YAG Laser and CO₂ Laser Treatment on Skin Tissue

Baleg

Bidin

Suan

et al. 2014

Photochem & Photobiology

View full text Add to dashboard Cite

Skin is the most important organ in our body, as it protects us from external environmental effects. Study the ability of the skin to stretch and the histological examinations of irradiated tissues have significant values in scientific and medical applications. Only a few studies have been done to study the correlation between epidermis ablation and the changes that occur at dermal levels when using dual lasers in ablative resurfacing mode. The aim of this work is to determine this correlation and to estimate the effects of multiple pulses on induced collagen remodeling and the strength of skin exposed with dual lasers in an in vivo rat model. All laser exposures led to mark improvement in the skin's strength compared to their own controls. The histological investigation indicated that there was a thickness loss in the epidermis layer with the induction of deep collagen coagulation in the dermis layer as the dual laser pulses increased. Additionally, more collagen fibers were remolded in the treated samples by dual wavelengths. We conclude that by combining dual lasers with multiple pulses targeted at not only the epidermis layer of the skin, it could also induce some heat diffusion in the dermis layer which causes more coagulation of collagen fibers. The tensile results confirmed by our histological data demonstrate that the strength of irradiated skin with dual wavelengths increased more than using both lasers separately on the skin tissue since more collagen is induced.

show abstract

“…Within 24 hours of wounding, keratinocytes migrate from wound edges and intact appendageal structures to repopulate the epidermis. 7,10 Fibroblasts begin to reconstitute the dermis with collagen, proteoglycans, and elastin within 3 to 4 days. 6,11 A separate proliferative phenotypethe myofibroblast-mediates wound contraction.…”

Section: Inflammatory Phasementioning

confidence: 99%

Scars after Second Intention Healing

Donaldson

Coldiron²

2012

Facial plast Surg

View full text Add to dashboard Cite

Second intention healing (SIH) is useful for many defects after skin cancer removal. SIH decreases intraoperative morbidity and reduces procedure costs. Granulating wounds are rarely infected, have minimal pain or bleeding, and care is simple. Location is the key determinant in cosmetic outcomes of SIH. Concavities of the face including the medial canthus and conchal bowl often heal imperceptibly. Defects on convex surfaces such as the nasal tip and malar cheek can heal poorly with depressed scars. Flat areas of the cheeks, forehead, and chin heal favorably but cosmesis can be unpredictable. These regions are often described by NEET (concavities of the nose, eyes, ears, and temple), NOCH (convexities of nose, oral lips, cheek, chin, and helix), and FAIR (flat areas of the forehead, antihelix of the ear, eyelids, and rest of the nose, lips, and cheeks). We review the limited literature describing SIH based on regional anatomy of the face. Complications of SIH include exuberant granulation tissue, hypopigmented or telangiectatic scars, and distortion of free lid margins. SIH should be an integral part of the surgeon's reconstructive algorithm after skin cancer removal.

show abstract

Role of the epidermis and other epithelia in wound healing: Selected concepts

Cited by 8 publications

References 41 publications

Skin Wound Healing: An Update on the Current Knowledge and Concepts

Skin Wound Healing: An Update on the Current Knowledge and Concepts

Combination of Er:YAG Laser and CO₂ Laser Treatment on Skin Tissue

Scars after Second Intention Healing

Contact Info

Product

Resources

About

Role of the epidermis and other epithelia in wound healing: Selected concepts

Cited by 8 publications

References 41 publications

Skin Wound Healing: An Update on the Current Knowledge and Concepts

Skin Wound Healing: An Update on the Current Knowledge and Concepts

Combination of Er:YAG Laser and CO2 Laser Treatment on Skin Tissue

Scars after Second Intention Healing

Contact Info

Product

Resources

About

Combination of Er:YAG Laser and CO₂ Laser Treatment on Skin Tissue