Role of the cerebellum in spatial orientation in the rat

Dahhaoui, M.; Lannou, J.; Stelz, T.; Caston, J.; Guastavinot, J.M.

doi:10.1016/0163-1047(92)90440-f

Cited by 34 publications

(17 citation statements)

References 24 publications

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“…Our prediction on the cerebellar role in path integration is in line with earlier proposals [92]–[94]. More recently, Korelusova et al [95] observed that, in a group of lurcher mice, those mice that in addition suffered from a retinal degeneration were not able to use idiothetic navigation to solve a spatial orientation task.…”

Section: Discussionsupporting

confidence: 91%

Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory

et al. 2012

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Complementing its primary role in motor control, cerebellar learning has also a bottom-up influence on cognitive functions, where high-level representations build up from elementary sensorimotor memories. In this paper we examine the cerebellar contribution to both procedural and declarative components of spatial cognition. To do so, we model a functional interplay between the cerebellum and the hippocampal formation during goal-oriented navigation. We reinterpret and complete existing genetic behavioural observations by means of quantitative accounts that cross-link synaptic plasticity mechanisms, single cell and population coding properties, and behavioural responses. In contrast to earlier hypotheses positing only a purely procedural impact of cerebellar adaptation deficits, our results suggest a cerebellar involvement in high-level aspects of behaviour. In particular, we propose that cerebellar learning mechanisms may influence hippocampal place fields, by contributing to the path integration process. Our simulations predict differences in place-cell discharge properties between normal mice and L7-PKCI mutant mice lacking long-term depression at cerebellar parallel fibre-Purkinje cell synapses. On the behavioural level, these results suggest that, by influencing the accuracy of hippocampal spatial codes, cerebellar deficits may impact the exploration-exploitation balance during spatial navigation.

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Section: Discussionsupporting

confidence: 91%

Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory

et al. 2012

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“…In effect, the behaviour of cerebellectomized rats (Dahhaoui et al 1992b) and of 3-AP-treated rats (unpublished results) was similar to that in the Morris water maze: lesioned animals learned the spatial task but their learning behaviour strongly suggested that the information processing had been altered by the lesion. However, the lesion (cerebellectomy or destruction of the IOC) done before the initial learning does not alter memory, since during the retrieval test the behaviour of these animals was similar to that of C rats.…”

Section: Discussionsupporting

confidence: 61%

Effects of lesion of the inferior olivary complex by 3-acetylpyridine on learning and memory in the rat

1992

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DA/HAN-strained male rats (pigmented rats) were submitted to two experimental tasks consisting of spatial learning (water-escape) and a passive avoidance conditioning. Both these tasks were performed by different animals. In order to destroy the inferior olivary complex, the animals were injected with 3-acetylpyridine either 9 days prior to the initial learning session or 24 h after completion of the learning task. They were retested (retrieval test) 10 days after the initial learning was achieved. Learning and retention were compared to those noted in control rats. Administration of 3-acetylpyridine before the initial learning did not prevent the spatial learning but the scores were greatly altered and the number of trials needed to reach the fixed learning criterion was much greater than in controls. However, 10 days later the animals had memorized their initial experience. Injection of 3-acetylpyridine after the initial learning session impaired memory: the animals had completely forgotten their initial learning. It can therefore be concluded that lesion of the afferent climbing fibres to the cerebellar cortex alters learning and retention of a spatial task. Such a lesion does not interfere with learning and retention of a passive avoidance conditioning, since in this condition the experimental animals injected with 3-acetylpyridine either before or after the initial learning behave similarly to controls. The effects of the inferior olivary complex lesion are obviously different according to the task to be learnt, suggesting that these two tasks do not require the integrity of the same nervous structures.

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“…The cerebellum plays a role in processing spatial information and in the acquisition of procedural components of spatial tasks (Dahhaoui et al 1992a; Flament et al 1996; Joyal et al 1996; Petrosini et al 1996). Specifically, cerebellar lesions or Purkinje cell loss can disrupt spatial learning and spatial memory without disrupting motor behavior (Dahhaoui et al 1992b; Joyal et al 1996; Leggio et al 1999; Martin et al 2003).…”

Section: Discussionmentioning

confidence: 99%

∆9-Tetrahydrocannabinol-dependent mice undergoing withdrawal display impaired spatial memory

et al. 2011

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Rationale Cannabis users display a constellation of withdrawal symptoms upon drug discontinuation, including sleep disturbances, irritability, and possibly memory deficits. In cannabinoid-dependent rodents, the CB1 antagonist rimona-bant precipitates somatic withdrawal and enhances forskolin-stimulated adenylyl cyclase activity in cerebellum, an effect opposite that of acutely administered Δ9-tetrahydrocannabinol (THC), the primary constituent in cannabis. Objectives Here, we tested whether THC-dependent mice undergoing rimonabant-precipitated withdrawal display short-term spatial memory deficits, as assessed in the Morris water maze. We also evaluated whether rimonabant would precipitate adenylyl cyclase superactivation in hippocampal and cerebellar tissue from THC-dependent mice. Results Rimonabant significantly impaired spatial memory of THC-dependent mice at lower doses than those necessary to precipitate somatic withdrawal behavior. In contrast, maze performance was near perfect in the cued task, suggesting sensorimotor function and motivational factors were unperturbed by the withdrawal state. Finally, rimonabant increased adenylyl cyclase activity in cerebellar, but not in hippocampal, membranes. Conclusions The memory disruptive effects of THC undergo tolerance following repeated dosing, while the withdrawal state leads to a rebound deficit in memory. These results establish spatial memory impairment as a particularly sensitive component of cannabinoid withdrawal, an effect that may be mediated through compensatory changes in the cerebellum.

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Role of the cerebellum in spatial orientation in the rat

Cited by 34 publications

References 24 publications

Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory

Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory

Effects of lesion of the inferior olivary complex by 3-acetylpyridine on learning and memory in the rat

∆9-Tetrahydrocannabinol-dependent mice undergoing withdrawal display impaired spatial memory

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