Role of the autonomic nervous system in atrial fibrillation pathogenesis

Popova, Ekaterine; Богова, О Т; Puzin, S. N; Фисенко, Владимир Петрович

doi:10.15829/1560-4071-2020-3663

Cited by 8 publications

(1 citation statement)

References 34 publications

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“…Current research suggests that air pollutants might cause acute cardiac events by affecting cardiac autonomic function, myocardial repolarization, local and systemic in ammation, reactive oxygen species, coagulation, and myocardial ischemia [29]. The development of AF involves three main mechanisms: in ammation, oxidative stress, and the autonomic nervous system [30][31][32][33]. Additionally, the Ang-II-MAPK and TGF-β1-Smad signaling pathways are thought to play central roles in regulating atrial brotic remodeling in AF.…”

Section: Mechanism Of Meteorological Factors Associated With Arrhythmiamentioning

confidence: 99%

Rapid weather changes are associated with daily hospital visitors for atrial fibrillation accompanied by abnormal ECG repolarization: A case-crossover study

Guo

Chen

et al. 2023

Preprint

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Background: Atrial fibrillation (AF) is highly prevalent in the population, yet the factors contributing to AF events in susceptible individuals remain partially understood. The potential relationship between meteorological factors and AF, particularly with abnormal electrocardiograph (ECG) repolarization, has not been adequately studied. This case-crossover study aims to investigate the association between meteorological factors and daily hospital visits for AFwith abnormal ECG repolarization in Shanghai, China. Methods: The study cohort comprised 10,325 patients with ECG-confirmed AF who sought treatment at Shanghai Sixth People's Hospital between 2015 and 2018. Meteorological and air pollutant concentration data were matched with the patient records. Using a case-crossover design, we analyzed the association between meteorological factors and the daily count of hospital visitors for AF with abnormal ECG repolarization at our AF center. Lag analysis models were applied to examine the temporal relationship between meteorological factors and AF events. Results: The analysis revealed statistically significant associations between AF occurrence and specific meteorological factors. AF events were significantly associated with average atmospheric pressure (lag0d,OR0.9901,95%CI0.9825~0.9977,P<0.05), average temperature (lag1d,OR0.9890,95%CI0.9789~0.9992,P<0.05), daily pressure range (lag7d,OR1.0195,95%CI1.0079~1.0312,P<0.01), and daily temperature range (lag5d,OR1.0208,95%CI1.0087~1.0331,P<0.01). Moreover, a significant correlation was observed between daily pressure range and daily temperature range with AF patients, particularly those with abnormal ECG repolarization, as evident in the case-crossover analysis. Conclusion:This study highlights a significant correlation between meteorological factors and daily hospital visits for AF in Shanghai, China. Additionally, AF patients with abnormal ECG repolarization were found to be more vulnerable to rapid daily changes in pressure and temperature compared to AF patients without such repolarization abnormalities.

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Section: Mechanism Of Meteorological Factors Associated With Arrhythmiamentioning

confidence: 99%

Rapid weather changes are associated with daily hospital visitors for atrial fibrillation accompanied by abnormal ECG repolarization: A case-crossover study

Guo

Chen

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Rapid weather changes are associated with daily hospital visitors for atrial fibrillation accompanied by abnormal ECG repolarization: a case-crossover study

Wu,

Guo,

Chen

et al. 2024

Eur J Med Res

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Background Atrial fibrillation (AF) is highly prevalent in the population, yet the factors contributing to AF events in susceptible individuals remain partially understood. The potential relationship between meteorological factors and AF, particularly with abnormal electrocardiograph (ECG) repolarization, has not been adequately studied. This case-crossover study aims to investigate the association between meteorological factors and daily hospital visits for AF with abnormal ECG repolarization in Shanghai, China. Methods The study cohort comprised 10,325 patients with ECG-confirmed AF who sought treatment at Shanghai Sixth People's Hospital between 2015 and 2018. Meteorological and air pollutant concentration data were matched with the patient records. Using a case-crossover design, we analyzed the association between meteorological factors and the daily count of hospital visitors for AF with abnormal ECG repolarization at our AF center. Lag analysis models were applied to examine the temporal relationship between meteorological factors and AF events. Results The analysis revealed statistically significant associations between AF occurrence and specific meteorological factors. AF events were significantly associated with average atmospheric pressure (lag 0 day, OR 0.9901, 95% CI 0.9825–0.9977, P < 0.05), average temperature (lag 1 day, OR 0.9890, 95% CI 0.9789–0.9992, P < 0.05), daily pressure range (lag 7 days, OR 1.0195, 95% CI 1.0079–1.0312, P < 0.01), and daily temperature range (lag 5 days, OR 1.0208, 95% CI 1.0087–1.0331, P < 0.01). Moreover, a significant correlation was observed between daily pressure range and daily temperature range with AF patients, particularly those with abnormal ECG repolarization, as evident in the case-crossover analysis. Conclusion This study highlights a significant correlation between meteorological factors and daily hospital visits for AF accompanied by abnormal ECG repolarization in Shanghai, China. In addition, AF patients with abnormal ECG repolarization were found to be more vulnerable to rapid daily changes in pressure and temperature compared to AF patients without such repolarization abnormalities.

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Does it make sense to study heart rate variability in episodes of paroxysmal atrial fibrillation during the 24-hour electrocardiographic monitoring?

et al. 2022

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Aim. To study the characteristics of heart rate variability (HRV) in episodes of paro xysmal atrial fibrillation (AF) and sinus rhythm (SR) during the 24-hour Holter electro cardiographic (ECG) monitoring and to assess the presence and nature of their relationships.Material and methods. We analyzed 37 records of 24-hour Holter ECG monitoring obtained from patients with paroxysmal AF. For analysis, records were selected from the Long Term Atrial Fibrillation database (LTAFDB) (n=26), as well as from the long-term storage database “Myocard-holter” of the Sverdlovsk Regional Clinical Hospital № 1 (n=11). Each record contained at least 120 min of SR and at least 120 min of paroxysmal AF episodes. In addition, 48 HRV indices were calculated independently for SR and for AF episodes, after which the 96 HRV parameters obtained for each record were subjected to exploratory data analysis.Results. Analysis of HRV in AF paroxysm showed a significant increase in the RMSSD, SD1, pNN50 indices, which confirmed the great importance of parasympathetic influence in the regulation of AF. Despite the fact that single HRV parameters in AF are not directly related to any single parameters in SR, we have shown that the AF is not completely chaotic and independent of the characteristics of baseline HR variability. We found that for some of the HRV indices determined during AF paroxysm (PAF_CVI, PAF_pNN20, PAF_pNN50, PAF_ApEn, PAF_SDNN, PAF_SD2), up to 74% of the variance of these indices can be explained using multivariate linear models, including 4 HRV indices for SR and taken as predictors. It was shown that among all the indices analyzed, only the PAF_HTI, calculated in paroxysmal AF, had a moderate negative correlation with the duration of AF episodes (r=0,60, p<0,01).Conclusion. It is shown that the study of HRV indices on AF paroxysm has a wide clinical and electrophysiological potential. The paper proposes statistical models that demonstrate the relationship between HRV in SR and in the rhythm of AF episode. The PAF_HTI index, assessed on episodes of AF, showed a relationship with the duration of AF episodes, which suggests the expediency of using HRV characteristics on AF to assess the possibility of SR recovery.

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Role of the autonomic nervous system in atrial fibrillation pathogenesis

Cited by 8 publications

References 34 publications

Rapid weather changes are associated with daily hospital visitors for atrial fibrillation accompanied by abnormal ECG repolarization: A case-crossover study

Rapid weather changes are associated with daily hospital visitors for atrial fibrillation accompanied by abnormal ECG repolarization: A case-crossover study

Rapid weather changes are associated with daily hospital visitors for atrial fibrillation accompanied by abnormal ECG repolarization: a case-crossover study

Does it make sense to study heart rate variability in episodes of paroxysmal atrial fibrillation during the 24-hour electrocardiographic monitoring?

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