Role of the Anterior Cingulate Cortex in the Control of Micturition Reflex in a Rat Model of Parkinson's Disease

Kitta, Takeya; Chancellor, Michael B.; Groat, William C. de; Shinohara, Nobuo; Yoshimura, Naoki

doi:10.1016/j.juro.2015.11.039

Cited by 24 publications

(15 citation statements)

References 27 publications

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“…In contrast to previous studies in healthy volunteers, neither the pons nor the ACC were activated during bladder filling in patients with Parkinson's disease [65]. In 6-OHDA injected rats, electrical stimulation of the ACC supressed the micturition reflex suggesting the ACC exerts inhibitory effects on micturition [66].…”

Section: The Role Of the Prefrontal Anterior Cingulate And Insula Cocontrasting

confidence: 97%

Lower urinary tract symptoms in Parkinson's disease: Prevalence, aetiology and management

McDonald

Winge

Burn

2017

Parkinsonism & Related Disorders

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Lower urinary tract symptoms (LUTS) are common in Parkinson's disease (PD), effecting 27-85% of patients with PD. Irritative symptoms predominate and urodynamic studies confirm high prevalence of detrusor overactivity in PD. LUTS are present early in PD and are more common in PD than in age matched controls. The assessment of LUTS in PD is complicated by coexisting bradykinesia and cognitive impairment. Although LUTS become more troublesome as PD progresses it remains unclear if LUTS severity correlates with motor symptoms and/or duration of PD. The underlying cause of LUTS in PD remains to be fully elucidated. Animal and human studies suggest the net effect of the basal ganglia is to supress micturition. Although LUTS are a common in PD, few studies have examined the assessment and management of LUTS specifically in patients with PD. Pilot studies have suggested that bladder training, antimuscarinic drugs and intravesical botulinum toxin maybe helpful but these trials have been small and frequently lacked a suitable control group making them vulnerable to the placebo effect. Furthermore the adverse effects of antimuscarinic drugs on cognitive and gastrointestinal function may limit the use of these drugs in PD. In this review we summarise the literature describing the prevalence of LUTS in PD, discuss the emerging data delineating the underlying pathophysiology of LUTS and examine interventions helpful in the management of LUTS in people with PD.

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Section: The Role Of the Prefrontal Anterior Cingulate And Insula Cocontrasting

confidence: 97%

Lower urinary tract symptoms in Parkinson's disease: Prevalence, aetiology and management

McDonald

Winge

Burn

2017

Parkinsonism & Related Disorders

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“…In the study reported herein, we found that the selective dopamine D1‐like receptor agonist, (±)‐SKF 38393 hydrochloride, increased the A‐URE value. Dopamine depletion in the nigrostriatal bundle can cause progressive degeneration of bladder function . We also demonstrated that (±)‐SKF 38393 hydrochloride enhanced urethral closure pressure, whereas the selective dopamine D2‐like receptor agonist, (–)‐quinpirole hydrochloride, impaired urethral closure in the bladder storage phase of PD rats.…”

Section: Discussionmentioning

confidence: 58%

“…Dopamine depletion in the nigrostriatal bundle can cause progressive degeneration of bladder function. 7,23 We also demonstrated that (±)-SKF 38393 hydrochloride enhanced urethral closure pressure, whereas the selective dopamine D2-like receptor agonist, (-)-quinpirole hydrochloride, impaired urethral closure in the bladder storage phase of PD rats. The detrusor overactivity has also been well known as supraspinal site through dopamine D1like receptors may mediate inhibition of the micturition reflex in both the normal and dopaminergic cell depleted condition.…”

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confidence: 67%

Dopaminergic urethral closure mechanisms in a rat model of Parkinson's disease

Ouchi

Kitta

Kanno

et al. 2019

Neurourology and Urodynamics

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Aims Urinary incontinence is prevalent among patients with Parkinson's disease (PD). In the present study, we investigated urethral functions in a rat model of PD induced by 6‐hydroxydopamine injection at their substantia nigra pars compacta as well as the roles of selective agonists/antagonist of dopamine D1‐ and D2‐like receptors in active urethral closure mechanisms. Methods We measured changes in the urethral pressure amplitude during electrical stimulation, urethral baseline pressure, and leak point pressure after intravenous administration of selective agonists or antagonists of the dopamine D1‐ and D2‐like receptors in a rat model of PD. Results The mean leak point pressure and the mean active urethral response values were significantly smaller for the untreated PD rat group compared with the control group. In PD model, the active urethral response increased significantly after treatment with the dopamine D1‐like receptor agonist, whereas that induced by the dopamine D2‐like receptor agonist decreased significantly. The response to the D2‐like receptor agonist was suppressed in the PD rat by the dopamine D2‐like receptor antagonist. Conclusion Our results suggest that the active urethral closure mechanisms are significantly impaired when dopamine is depleted. In the PD rat, dopamine D1‐like receptor activity on the central nervous system appear to partially compensate for urethral functions negatively impacted by the lack of dopamine, whereas dopamine D2‐like receptor activity might exacerbate urinary leakage owing to the negative effect of this activated receptor on urethral pressure under increased intra‐abdominal pressure.

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“…PD-UU can be caused by the neurodegenerative processes of the prefrontal cortex since the frontal cortex-basal ganglia circuit plays a prominent role not only in modulating EF and goal-directed behavior (Funahashi, 2001) but also in suppressing micturition (Winge, 2015). Neuroimaging studies identified that the prefrontal cortex is activated during bladder filling (Kitta et al, 2016) and that progressive neurodegenerative changes in PD cause disruptions of these patterns (Kitta et al, 2006;Fowler and Griffiths, 2010). The causality of connection between EF and PD-UU should be considered as bidirectional, as executive impairment might additionally prevent PD patients from planning or inhibiting physiological processes that lead to PD-UU.…”

Section: Discussionmentioning

confidence: 99%

Executive Function Is Related to the Urinary Urgency in Non-demented Patients With Parkinson’s Disease

Tkaczynska

Becker

Maetzler

et al. 2020

Front. Aging Neurosci.

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Introduction: Evidence suggests urinary urgency is associated with cognitive impairment in a subtype of Parkinson's disease (PD) patients. This study investigates if cognitive impairment independently predicts the presence of urinary dysfunction. Methods: We report data of 189 idiopathic PD patients, excluding those with concomitant diseases or medication interacting with bladder function. A standardized questionnaire was used to define the presence of urinary urgency. All patients underwent a comprehensive motor, cognitive non-motor and health-related quality of life (HRQoL) assessment. Multivariable linear regression analysis was performed to identify independent variables characterizing urinary urgency in PD (PD-UU), which were assigned as discriminant features to estimate their individual contribution to the phenotype of the PD-UU group. Results: Of 189 PD patients, 115 (60.8%) reported PD-UU. The linear regression analysis showed that among cognitive domains, executive function (EF; p = 0.04) had a significant negative association with PD-UU. In a second model, scores of the Montreal Cognitive Assessment (MoCA) significantly differentiated between study groups (p = 0.007) and also non-motor symptom (NMS) burden (p < 0.001). The third model consisted of reports of HRQoL, of which stigma was the only subscale of the Parkinson's Disease Questionnaire (PDQ-39) differentiating between patients with and without PD-UU (p = 0.02). The linear discriminant analysis provided evidence that the combination of EF, NMS burden, nocturia, and stigma discriminated between groups with 72.4% accuracy. Conclusion: In our large, non-demented PD cohort, urinary urgency was associated with executive dysfunction (EF), supporting a possible causative link between both symptoms. A combination of neuropsychological and non-motor aspects identified patients with PD-UU with high discriminative accuracy.

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Role of the Anterior Cingulate Cortex in the Control of Micturition Reflex in a Rat Model of Parkinson's Disease

Cited by 24 publications

References 27 publications

Lower urinary tract symptoms in Parkinson's disease: Prevalence, aetiology and management

Lower urinary tract symptoms in Parkinson's disease: Prevalence, aetiology and management

Dopaminergic urethral closure mechanisms in a rat model of Parkinson's disease

Executive Function Is Related to the Urinary Urgency in Non-demented Patients With Parkinson’s Disease

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