Role of Terpenoids Active Ingredients Targeting for Neuroprotective Agents

Kashyap, Neelmani; Kumar, Roshan; Rana, Vinod; Sood, Prachi; Chauhan, Tanshavi

doi:10.55544/jrasb.2.3.5

Cited by 12 publications

(4 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Structurally, 2-BTHF has been identified as a heterocyclic tetrahydrofuran (THF) compound, specifically a cyclic ether . A high concentration of THF has also been reported in terpenoid research, demonstrating enhanced bioactivity, including anti-Aβ aggregation, antioxidant, and anti-inflammatory properties. , Crown ethers, which are cyclic polyethers, have also been reported to inhibit amyloidosis and the formation of amyloid fibrils . Therefore, it is possible that the cyclic ether 2-BTHF at 100 μM could interfere with fibrils in α-synuclein, acting as an effective dose for attenuating α-synuclein accumulation in transgenic C.…”

Section: Resultsmentioning

confidence: 99%

2-Butoxytetrahydrofuran, Isolated from Holothuria scabra, Attenuates Aggregative and Oxidative Properties of α-Synuclein and Alleviates Its Toxicity in a Transgenic Caenorhabditis elegans Model of Parkinson’s Disease

Promtang,

Sanguanphun,

Chalorak

et al. 2024

ACS Chem. Neurosci.

View full text Add to dashboard Cite

Aggregative α-synuclein and incurring oxidative stress are pivotal cascading events, leading to dopaminergic (DAergic) neuronal loss and contributing to clinical manifestations of Parkinson's disease (PD). Our previous study demonstrated that 2-butoxytetrahydrofuran (2-BTHF), isolated from Holothuria scabra (H. scabra), could inhibit amyloid-β aggregation and its ensuing toxicity, which leads to Alzheimer's disease. In the present study, we found that 2-BTHF also attenuated the aggregative and oxidative activities of α-synuclein and lessened its toxicity in a transgenic Caenorhabditis elegans (C. elegans) PD model. Such worms treated with 100 μM of 2-BTHF showed substantial reductions in αsynuclein accumulation and DAergic neurodegeneration. Mechanistically, 2-BTHF, at this concentration, significantly decreased aggregation of monomeric α-synuclein and restored locomotion and dopamine-dependent behaviors. Molecular docking exhibited potential bindings of 2-BTHF to HSF-1 and DAF-16 transcription factors. Additionally, 2-BTHF significantly increased the mRNA transcripts of genes encoding proteins involved in proteostasis, including the molecular chaperones hsp-16.2 and hsp-16.49, the ubiquitination/SUMOylation-related ubc-9 gene, and the autophagy-related genes atg-7 and lgg-1. Transcriptomic profiling revealed an additional mechanism of 2-BTHF in α-synuclein-expressing worms, which showed upregulation of PPAR signaling cascades that mediated fatty acid metabolism. 2-BTHF significantly restored lipid deposition, upregulated the fat-7 gene, and enhanced gcs-1-mediated glutathione synthesis in the C. elegans PD model. Taken together, this study demonstrated that 2-BTHF could abrogate aggregative and oxidative properties of α-synuclein and attenuate its toxicity, thus providing a possible therapeutic application for the treatment of α-synuclein-induced PD.

show abstract

Section: Resultsmentioning

confidence: 99%

2-Butoxytetrahydrofuran, Isolated from Holothuria scabra, Attenuates Aggregative and Oxidative Properties of α-Synuclein and Alleviates Its Toxicity in a Transgenic Caenorhabditis elegans Model of Parkinson’s Disease

Promtang,

Sanguanphun,

Chalorak

et al. 2024

ACS Chem. Neurosci.

View full text Add to dashboard Cite

show abstract

“…This, in turn, forces more NADH or FADH2 into the mitochondrial electron transport chain. As a result of the obstruction in electron transfer, molecular oxygen is able to generate superoxide with the assistance of coenzyme Q, which ultimately results in an excessive amount of reactive oxygen species (ROS) [20]. The dissociation of the relationship between reactive oxygen species (ROS) and hyperglycemia can be accomplished by uncoupling mitochondrial electron transport, which can be accomplished by overexpressing uncoupling protein (UCP) to collapse voltage gradient [21].…”

Section: Introductionmentioning

confidence: 99%

Diabetic Retinopathy: Current Understanding, Mechanisms and Treatment Strategies

Amjad,

Gupta,

Anamika

et al. 2024

J. Res. Appl. Sci. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Researchers have been assuming about the possible connection between the eye and the central nervous system (CNS) for a considerable amount of time. This is primarily due to the fact that the eye is considered to be an extension of the brain, which is a reasonable assumption. The neural tube is the beginning of both structures, and neurons are the building blocks of both structures. Retinal ganglionic cells, also known as RGCs, are a specific type of cell that are found in the retina. These cells are responsible for receiving light signals from the environment around them and then transmitting them to photoreceptors, which are involved in the process of vision. The retina, which is found inside the eye, is responsible for converting light into electrical impulses, which are then sent to the brain through the optic nerve. Glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy are only few of the eye illnesses that can be caused by chronic progressive neurodegeneration of the retina, which is more prevalent in older people. It is the elderly who are most likely to be affected by these eye disorders; nevertheless, younger people are also susceptible to them and may experience permanent vision loss or a reduction in their eyesight. In most cases, neurodegenerative disorders that are characteristic of CSN are characterised by common symptoms and a cause that is only partially understood. Although certain risk factors have been identified, they do not account for all instances. On the other hand, according to a number of studies, several illnesses of the central nervous system (CNS), such as Alzheimer's disease (AD) and Parkinson's disease (PD), which are responsible for a significant amount of mortality and morbidity on a global scale, display distinctive alterations at the ocular level. It is helpful to be aware of potential linkages in order to have a better understanding of the mechanics on which onset occurs. In addition, experts have not yet reached a consensus regarding the factors that are responsible for these various disorders. In this overview, the symptoms of ocular illnesses are discussed in detail, with a particular focus on the interaction between the brain and the eye. At some point in the future, a more in-depth understanding could be of assistance in the development of innovative treatments that could help reduce or prevent blindness and improve quality of life.

show abstract

“…Here, we looked into whether or not different MHR preparations could prevent heart damage that had been caused in the lab. We utilised the nonselectiveadrenergic agonist isoproterenol (ISO; 1-(3′,4′dihydroxyphenyl)-2-isopropylaminoethanol hydrochloride), which produces infarct-like necrosis of the heart muscle in rats [15][16][17], followed by leaking of cardiac enzymes into the circulation. The cardioprotective effects of MHR were investigated in rats exposed to isoproterenol.…”

Section: Introductionmentioning

confidence: 99%

Plant & its Bioactive Components Uses in Cardio-Potential Diseases: A Sectional Study for Different Herbs

Kumar,

Sood,

Nirala

et al. 2023

J. Res. Appl. Sci. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Thirty percent of all deaths that occur each year can be attributed to heart disease, stroke, and other forms of cardiovascular disease. The World Health Organisation (WHO) predicts that by the year 2030, the annual death toll from cardiovascular diseases will have increased to 22.2 million, up from the present annual total of 17.9 million. Mortality rates tend to go up in populations as they get older. The chance of dying from cardiovascular disease is significantly higher for females (51%) than it is for males (42%). The majority of people treat and prevent cardiovascular disease by using plant-based medications (also known as phytochemicals), either in addition to or in instead of pharmaceuticals that are readily available on the market. In this study, the efficacy of treating cardiovascular illness is evaluated using 92 different plants, including 15 terrestrial plants. A number of different medicinal herbs, including Daucus carota, Nerium oleander, Amaranthus Viridis, Ginkgo biloba, Terminalia arjuna, Picrorhiza kurroa, Salvia miltiorrhiza, Tinospora cordifolia, Mucuna pruriens, Hydrocotyle asiatica, Bombax ceiba, and Andrographis paniculate, are utilised to treat cardiovascular disease. There are a variety of active phytochemicals found in these plants, some of which include flavonoids, polyphenols, plant sterols, plant sulphur compounds, and terpenoids. Flavonoids, in general, are known to increase vasodilation by inhibiting the oxidation of low-density lipoprotein (LDL). Plant sterols reduce the amount of cholesterol in the blood, which in turn protects against cardiovascular disease. Plant sulphur compounds protect against cardiovascular disease in addition to their role in the activation of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) and the inhibition of cholesterol formation. The incidence of cardiovascular disease can be reduced by increasing the synthesis of ATP in mitochondria, and terpenoids can diminish atherosclerotic lesion in the aortic valve. Even though several physiologically active compounds with acknowledged biological functions have been found in a wide variety of plants, the prevalence of cardiovascular disease continues to rise, making it imperative that effective CVD prevention and treatment strategies be developed. More research is required to understand both the mechanism and the individual phytochemicals in plants that treat CVD. GRAPHICAL ABSTRACT

show abstract

Role of Terpenoids Active Ingredients Targeting for Neuroprotective Agents

Cited by 12 publications

References 109 publications

2-Butoxytetrahydrofuran, Isolated from Holothuria scabra, Attenuates Aggregative and Oxidative Properties of α-Synuclein and Alleviates Its Toxicity in a Transgenic Caenorhabditis elegans Model of Parkinson’s Disease

2-Butoxytetrahydrofuran, Isolated from Holothuria scabra, Attenuates Aggregative and Oxidative Properties of α-Synuclein and Alleviates Its Toxicity in a Transgenic Caenorhabditis elegans Model of Parkinson’s Disease

Diabetic Retinopathy: Current Understanding, Mechanisms and Treatment Strategies

Plant & its Bioactive Components Uses in Cardio-Potential Diseases: A Sectional Study for Different Herbs

Contact Info

Product

Resources

About