Role of taurine on acid secretion in the rat stomach

“…It acts as an antioxidant, xenobiotic conjugant, osmoregulator, intracellular calcium flux regulator, bile acid conjugator, neuromodulator, cell membrane stabilizer, and also plays an important role in cell proliferation and viability (Huxtable 1992;Harada et al 2000;No authors listed 2001;Oja and Saransaari 2007). Taurine is known to have regulatory activities in gastrointestinal tract including modulation of acid secretion and gastric motility (Huang et al 2011); besides, it protects the gastrointestinal mucosa from the injuries (Son et al 1996). It could also enhance the absorption of some drugs (Kim et al 1982) and attenuates stress-induced gastrointestinal disease (Zeybek et al 2006) and drug-induced inflammation or damage (Balasubramanian et al 2004;Şener et al 2005).…”

Section: Introductionmentioning

confidence: 97%

Taurine attenuates chemotherapy-induced nausea and vomiting in acute lymphoblastic leukemia

et al. 2014

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Taurine has multiple physiological activities and it is decreased by chemotherapy. The purpose of our study was to evaluate the effect of oral taurine supplementation on the incidence of chemotherapy-induced nausea and vomiting in patients with acute lymphoblastic leukemia. Forty young patients aged over 16 (range: 16-23 years) suffering from acute lymphoblastic leukemia (all receiving same chemotherapy regimen) were recruited for the study at the beginning of maintenance course of their chemotherapy. The study population was randomized in a double-blind manner to receive either taurine or placebo (2 g per day orally, divided into two doses, taken 6 h after chemotherapeutic agents) for 6 months. Life quality and adverse effects including nausea and vomiting, taste and smell alterations, and weariness were assessed using a questionnaire. Data were analyzed using Pearson's Chi-square test. Of 40 participants, 32 finished the study (14 female and 18 male; mean age 19.2 ± 1.9 years). Four treatment and four placebo arm patients discontinued: one immigrated from the province, one died during the study, and six refused to continue. The results indicated that taurine-supplemented patients reported a significant (P < 0.05) improvement in chemotherapy-induced nausea and/or vomiting after taking taurine during study. Taurine significantly improved chemotherapy-induced taste and smell alterations (P < 0.05). Moreover, taurine significantly reduced weariness compared to placebo group (P < 0.05). This study showed that taurine co-administration decreased chemotherapy-induced nausea and vomiting during the maintenance therapy in acute lymphoblastic leukemia.

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“…Elevated concentration of taurine in plasma and urine has already been reported following surgical trauma [16], muscle necrosis [17], acetaminophen overdose [18] and heroin addiction [19]. Accumulating evidence indicates that taurine might function as an inhibitory modulator or neurotransmitter in many cerebral areas [20].…”

Section: Introductionmentioning

confidence: 99%