Role of tau protein on neocortical and hippocampal oscillatory patterns

Cantero, José L.; Moreno‐López, Bernardo; Portillo, Fédérico; Rubio, Alicia; Hita-Yáñez, Eva; Ávila, Jesús

doi:10.1002/hipo.20798

Cited by 28 publications

(23 citation statements)

References 66 publications

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“…These place cells encode a spatial map of the animal's environment (O'Keefe and Nadel, ; Moser et al, ). Furthermore, tau knockout mice show different oscillatory patterns (Cantero et al, ).…”

Section: Discussionmentioning

confidence: 99%

Tau phosphorylation‐associated spine regression does not impair hippocampal‐dependent memory in hibernating golden hamsters

et al. 2015

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The microtubule-associated protein tau, in its hyperphosphorylated form, is the major component of paired helical filaments and other aggregates in neurodegenerative disorders commonly referred to as "tauopathies". Recent evidence, however, indicates that mislocalization of hyperphosphorylated tau to subsynaptic sites leads to synaptic impairment and cognitive decline even long before formation of tau aggregates and neurodegeneration occur. A similar, but reversible hyperphosphorylation of tau occurs under physiologically controlled conditions during hibernation. Here, we study the hibernating Golden hamster (Syrian hamster, Mesocricetus auratus). A transient spine reduction was observed in the hippocampus, especially on apical dendrites of hippocampal CA3 pyramidal cells, but not on their basal dendrites. This distribution of structural synaptic regression was correlated to the distribution of phosphorylated tau, which was highly abundant in apical dendrites but hardly detectable in basal dendrites. Surprisingly, hippocampal memory assessed by a labyrinth maze was not affected by hibernation. The present study suggests a role for soluble hyperphosphorylated tau in the process of reversible synaptic regression, which does not lead to memory impairment during hibernation. We hypothesize that tau phosphorylation associated spine regression might mainly affect unstable/dynamic spines while sparing established/stable spines.

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Section: Discussionmentioning

confidence: 99%

Tau phosphorylation‐associated spine regression does not impair hippocampal‐dependent memory in hibernating golden hamsters

et al. 2015

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“…Tau knockout mice have decreased peak frequency of theta waves in the hippocampus and decreased coherence of gamma waves in the frontal cortex (Cantero et al). The potential effects of these alterations on Aβ-induced dysrythmias and cognitive abnormalities remain to be determined.…”

Section: Mechanisms By Which Tau Contributes To Diseasementioning

confidence: 99%

The Many Faces of Tau

Morris

Maeda

Vossel

et al. 2011

Neuron

745

699

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“…Cantero and colleagues examined the local field potential from various cortical regions and hippocampus of tau knockout mice to determine if delayed axonal maturation of tau knockout neurons observed in vitro [40] could possibly affect neuronal circuit formation in vivo [51]. They found slower theta rhythms of the hippocampus and reduced gamma synchronization between cortical brain regions in tau knockout mice, which may suggest impaired circuit formation.…”

Section: Deficits In Tau Knockout Micementioning

confidence: 99%

Lessons from Tau-Deficient Mice

Suchowerska

Hoven

et al. 2012

International Journal of Alzheimer's Disease

100

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Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. This unifying pathology led to the umbrella term “tauopathies” for these conditions, also emphasizing the central role of tau in AD and FTD. Generation of transgenic mouse models expressing human tau in the brain has contributed to the understanding of the pathomechanistic role of tau in disease. To reveal the physiological functions of tau in vivo, several knockout mouse strains with deletion of the tau-encoding MAPT gene have been established over the past decade, using different gene targeting constructs. Surprisingly, when initially introduced tau knockout mice presented with no overt phenotype or malformations. The number of publications using tau knockout mice has recently markedly increased, and both behavioural changes and motor deficits have been identified in aged mice of certain strains. Moreover, tau knockout mice have been instrumental in identifying novel functions of tau, both in cultured neurons and in vivo. Importantly, tau knockout mice have significantly contributed to the understanding of the pathophysiological interplay between Aβ and tau in AD. Here, we review the literature that involves tau knockout mice to summarize what we have learned so far from depleting tau in vivo.

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Role of tau protein on neocortical and hippocampal oscillatory patterns

Cited by 28 publications

References 66 publications

Tau phosphorylation‐associated spine regression does not impair hippocampal‐dependent memory in hibernating golden hamsters

Tau phosphorylation‐associated spine regression does not impair hippocampal‐dependent memory in hibernating golden hamsters

The Many Faces of Tau

Lessons from Tau-Deficient Mice

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