Role of targeting nanoparticles for cancer immunotherapy and imaging

Wen, Ru; Umeano, Afoma

doi:10.24294/ti.v1.i3.95

Cited by 4 publications

(3 citation statements)

References 58 publications

(60 reference statements)

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“…The development of a cancer vaccine potentiates the need for robust delivery systems applicable to various diseases and cancers. Nanoparticles can be used as delivery systems for various diseases, including cancer [17]. Nanoparticles can be used to deliver antigens and prime immune cells as vaccines, or as adjuvants to enhance cancer immune response.…”

Section: Nanoparticles As Vaccine Delivery Systemsmentioning

confidence: 99%

Nanoparticle systems for cancer vaccine

et al. 2019

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As effective tools for public health, vaccines prevent disease by priming the body's adaptive and innate immune responses against an infection. Due to advances in understanding cancers and their relationship with the immune system, there is a growing interest in priming host immune defenses for a targeted and complete antitumor response. Nanoparticle systems have shown to be promising tools for effective antigen delivery as vaccines and/or for potentiating immune response as adjuvants. Here, we highlight relevant physiological processes involved in vaccine delivery, review recent advances in the use of nanoparticle systems for vaccines and discuss pertinent challenges to viably translate nanoparticle-based vaccines and adjuvants for public use.

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Section: Nanoparticles As Vaccine Delivery Systemsmentioning

confidence: 99%

Nanoparticle systems for cancer vaccine

et al. 2019

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“…Several efforts have been made to enhance drug delivery to the brain, including: tight junction opening, via infusion of hyperosmotic agents; surfactants or bioactive molecules; chemical modification of the drug, in order to create more lipophilic prodrug; inhibition of efflux transporters present at the BBB, such as P-gp; convention-enhanced drug delivery; and craniotomy-based drug delivery [ 75 ]. Another recent and promising therapeutic strategy is based on nanotechnology [ 72 , 76 – 78 ]. Colloidal nanocarriers, liposomes, polymeric nanoparticles (PNPs) and lipid nanocapsules (LNCs) could ameliorate effectiveness, diminish non-specific toxicity and raise stability of drugs, and could also facilitate drug delivery to the brain tumors, which is hampered by the BBB [ 75 ].…”

Section: The Role Of Mif In Glioblastomamentioning

confidence: 99%

Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach

et al. 2018

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Macrophage Migration Inhibitory Factor (MIF) is a pro-inflammatory cytokine expressed by a variety of cell types. Although MIF has been primarily studied for its role in the pathogenesis of autoimmune diseases, it has also been shown to promote tumorigenesis and it is over expressed in various malignant tumors. MIF is able to induce angiogenesis, cell cycle progression, and to block apoptosis. As tailored therapeutic approaches for the inhibition of endogenous MIF are being developed, it is important to evaluate the role of MIF in individual neoplastic conditions that may benefit from specific MIF inhibitors. Along with this line, in this paper, we have reviewed the evidence of the involvement of MIF in the etiopathogenesis and progression of glioblastoma and the preclinical data suggesting the possible use of specific MIF inhibition as a potential novel therapeutic strategy for brain tumors.

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“…However, it is inevitable that cement ratio will increase in proportion to water added. Therefore, it would be desirable to obtain finer aggregates in order for a proper workability [43]. It is worth noting that the CaCO3 based aggregates produce materials that share similar chemical compositions with the dehydrated cement paste and hence it may be a viable approach to utilize the dehydrated concretes directly and avoiding the separation step.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties and Microstructures of Regenerated Cement From Waste Concrete

Zuo

2017

JESR

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It has been a long time since humans started using waste materials in engineering applications. This approach not only reduces the yield of waste, while minimizing the costs of disposal but also limit the cost of new materials. In the field of construction, the reuse of waste concretes has been a strong research in recent years. However the processing of the wastes normally involves complicated processing and lab equipment. In this report we crush and dehydrate waste concretes with normal lab facilities and re-make the cement composites. The waste concretes were crushed and dehydrated at two temperatures, 1280 and 1400 ˚C. To balance the concentration of silica and lime, extra lime at 28.5 % and 16 % were added to the waste concretes. The resultant materials were evaluated with respect to the chemical composition, mechanical properties, and microstructures. It is concluded that the material dehydrated at 1400 ˚C and containing 28.5 % lime presents the best mechanical performance. This report presents a simple and inexpensive method to reuse the waste concretes in applications such as pavements.

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Role of targeting nanoparticles for cancer immunotherapy and imaging

Cited by 4 publications

References 58 publications

Nanoparticle systems for cancer vaccine

Nanoparticle systems for cancer vaccine

Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach

Mechanical Properties and Microstructures of Regenerated Cement From Waste Concrete

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