Role of tapentadol in pain management

Mendis, Victor

doi:10.4038/slja.v22i1.6239

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…Tramadol is metabolised to an active O-desmethyl metabolite which is responsible for these side effects. [ 8 18 19 ] Several authors have observed an increased incidence of PONV and sedation with tramadol. [ 4 9 ] Sedation was observed in six patients in tramadol group and none in tapentadol group ( P = 0.027) in this study; nevertheless, tapentadol appears to have a better central nervous system and gastrointestinal tolerability profile owing to lack of significant serotonergic activity.…”

Section: Discussionmentioning

confidence: 99%

“…[ 4 9 ] Sedation was observed in six patients in tramadol group and none in tapentadol group ( P = 0.027) in this study; nevertheless, tapentadol appears to have a better central nervous system and gastrointestinal tolerability profile owing to lack of significant serotonergic activity. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

“…These mechanisms complement each other and clearly have a role in nociceptive and neuropathic pain management. [ 8 ] Tapentadol is one of the most promising opioid analgesics and has never been tested for its potential in the management of CRBD.…”

Section: Introductionmentioning

confidence: 99%

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Comparison between pre-emptive oral tramadol and tapentadol for attenuation of catheter-related bladder discomfort and surgical stress response in patients undergoing transurethral resection of prostate: A prospective, randomised, double-blind trial

Kumar¹,

Bindal²,

Oberoi³

et al. 2021

Indian J Anaesth

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Background and Aims: Surgical interventions involving urinary catheterisation often lead to catheter-related bladder discomfort (CRBD). With a very high incidence rate of 47%–90%, CRBD often leads to a distressing and painful recovery after surgery. Although many opioids have been used for the treatment of CRBD, the search for the best is still going on. This study investigated the efficacy and tolerability of oral tapentadol and tramadol on postoperative CRBD. Methods: This was a prospective, randomised double-blind study. 100 patients, undergoing transurethral resection of the prostate were randomly assigned into two groups to receive tramadol 100 mg (Group A) or tapentadol 50 mg (Group B) orally 1 h before surgery. CRBD was evaluated on a 4-point severity scale in the post-operative area at 0, 0.5, 1, 2, 3, 4, 5 and 6 h. Pain and adverse effects were assessed postoperatively. Serum cortisol levels before and after the procedure were noted. Statistical analysis was done with the analysis of variance, t test. Results: Postoperative CRBD, 2 h after surgery was significantly reduced in group B than group A ( P = 0.012). Cortisol levels, postoperatively were significantly lower in Group B (113 ± 65.45) ( P = 0.001) than group A (162.64 ± 118.84 ng/dL). Dry mouth was seen in four, nausea in eight and sedation in six patients in group A while none in group B. 14 patients in Group A and one patient in Group B needed intravenous paracetamol ( P = 0.000). Conclusions: Premedication with tapentadol was more effective in reducing CRBD and pain postoperatively. The surgical stress response and side effects were significantly reduced with tapentadol.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison between pre-emptive oral tramadol and tapentadol for attenuation of catheter-related bladder discomfort and surgical stress response in patients undergoing transurethral resection of prostate: A prospective, randomised, double-blind trial

Kumar¹,

Bindal²,

Oberoi³

et al. 2021

Indian J Anaesth

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“…It has been advised not to use tapentadol when the patient has CNS and/or respiratory depression. [ 12 ] Tapentadol has no active metabolites. The respiratory rate and oxygen saturation were similar between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Comparison of tapentadol with tramadol for analgesia after cardiac surgery

et al. 2015

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Background:Tapentadol is a relatively new analgesic. We decided to compare it with tramadol for their various effects after cardiac surgery.Setting:A study in a tertiary care hospital.Materials and Methods:Sixty adults undergoing cardiac surgery were divided into 2 groups of 30 each by computerized random allotment (Group X = tapentadol 50 mg oral and Group Y = tramadol 100 mg oral). Informed Consent and Institutional Ethics Committee approval were obtained. The patients were given either drug X or drug Y after extubation in this single blinded study, wherein the data collectors and analyzers were blinded to the study. All patients received oral paracetamol qds and either drug X or drug Y tds. The pain score was noted on a Visual Analog Scale before each drug dose, 3 h later and on coughing. Heart rate, respiratory rate, and blood pressure were recorded before the drug dose and 3 h later. Postoperative nausea or vomiting (PONV), temperature, and modified Glasgow Coma Scale readings were recorded. The above readings were obtained for 6 doses (up to 48 h after extubation).Statistics:t-test, Pearson Chi-square test, Fisher exact test, and Mantel–Haenszel test were used for statistics.Results:Tapentadol group patients had significantly better analgesia 3 h after the drug and “on coughing” than tramadol group. The difference in their effects on blood creatinine levels, temperature, hemodynamics, oxygen saturation, and respiratory rate were not clinically significant. Tapentadol produced lesser drowsiness and lesser vomiting than tramadol.Conclusions:Tapentadol, due to its norepinephrine reuptake inhibition properties, in addition to mu agonist, is a better analgesic than tramadol and has lesser PONV.

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“…Ninguno de los metabolitos contribuye a la actividad analgésica. 11 Tapentadol es 18 veces menos potente que la morfina para unirse al receptor opioide μ humano y 2-3 veces menos potente para producir analgesia en los modelos animales, lo cual es consistente con su mecanismo de acción combinada. En modelos preclínicos, la actividad analgésica debida a los agonistas opioides del receptor μ de tapentadol se puede modular mediante antagonistas selectivos de los receptores opioides μ (por ej., naloxona), mientras que la recaptación de la inhibición de noradrenalina es sensible a los moduladores de norepinefrina.…”

Section: Introductionunclassified