Role of Tamsulosin, Tadalafil, and Silodosin as the Medical Expulsive Therapy in Lower Ureteric Stone: A Randomized Trial (a Pilot Study)

Kumar, Sheetanshu; Jayant, Kumar; Agrawal, Mayank Mohan; Singh, Shrawan Kumar; Agrawal, Swati; Parmar, Kalpesh

doi:10.1016/j.urology.2014.09.022

Cited by 63 publications

(101 citation statements)

References 26 publications

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“…Our results are in agreement with those of Gupta et al [12] , who reported stone clearance rates of 82% and 58% for their silodosin and tamsulosin groups, respectively; and also in agreement with those of Kumar et al [13] , who reported stone clearance rates of 83.3% and 64.4% for their silodosin and tamsulosin groups, respectively. However, Imperatore et al [14] reported a nonsignificant difference of stone clearance rates between silodosin (88%) and tamsulosin (84%).…”

Section: Discussionsupporting

confidence: 93%

Comparative Efficacy of Silodosin vs Tamsulosin for Ureteric Calculus: A Single Centre Double Blind Randomised Controlled Trial

Antony¹

2017

jmscr

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Section: Discussionsupporting

confidence: 93%

Comparative Efficacy of Silodosin vs Tamsulosin for Ureteric Calculus: A Single Centre Double Blind Randomised Controlled Trial

Antony¹

2017

jmscr

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“…In a study by Kumar et al [21] the incidence of drug-related side effects like headache, dizziness, backache and orthostatic hypotension was significantly higher in the tadalafil group. Abnormal ejaculation was seen in 15.6%, and 5.9% of the patients in the silodosin, and tadalafil groups, respectively, without any statistically significant difference.…”

Section: Discussionmentioning

confidence: 91%

Safety and efficacy of silodosin and tadalafil in ease of negotiation of large ureteroscope in the management of ureteral stone: A prosective randomized trial

Bhattar¹,

Jain²,

Tomar³

et al. 2017

Turkish Journal of Urology

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Objective: To evaluate the safety and efficacy of silodosin and tadalafil in ease of negotiation of large size ureteroscope (8/9.8 Fr) in the management of ureteral stone. Material and methods:Between June 2015 and May 2016, 86 patients presented with ureteral stone of size 6-15 mm were on consent randomly assigned to 1 of 3 outpatient treatment arms: silodosin (Group A), tadalafil (Group B), and placebo (Group C). After two weeks of therapy 67 patients underwent ureteroscopy, and ureteral orifice configuration, ureteroscopic negotiation, ureteral dilatation, operating time, procedural complication and drug related side effects were noted in each group.Results: Ureteral negotiation was significantly better in Groups A (73.9%) and B (69.6%) as compared to Group C (38.1%) (p<0.01). Statistically significant difference was noted in the requirement for dilatation in Group C (71.4%) as compared to Groups A (26.1%) and B (39.1%) (p<0.01). Ureteral orifice was found to be more dilated in Groups A (69.6%) and B (60.9%) as compared to Group C (28.6%). Mean operating time was statistically lower in Groups A (35.2 min) and B (34.91 min) as compared to Group C (41.14 min) (p<0.01). Conclusion:Both silodosin and tadalafil not only relax ureteral smooth muscle but also help in forward propagation of large size ureteroscope (8/9.8 Fr) without any significant risk of adverse events.Keywords: Silodosin; tadalafil; ureteral stone; ureteroscope; ureteral orifice.Cite this article as: Bhattar R, Jain V, Tomar V, Yadav SS. Safety and efficacy of silodosin and tadalafil in ease of negotiation of large ureteroscope in management of ureteral stone: A prosective randomized trial. Turk J Urol 2017; 43(4): 484-9

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“…[14][15][16]19,20 Three studies reported the results of Silodosin compared with placebo for ureteral calculi; four studies compared the efficacy of Silodosin with that of tamsulosin or naftopidil for ureteral calculi and were included the final metaanalysis. In this meta-analysis, two studies reported sample size calculations.…”

Section: Resultsmentioning

confidence: 99%

“…In this meta-analysis, two studies reported sample size calculations. 13,19 The quality and detailed characteristics of included studies are shown in Table 1. Figure 2.…”

Section: Resultsmentioning

confidence: 99%

“…However, we also found the odds ratios were higher for Silodosin over tamsulosin when one would thought that it would be greater for Silodosin over placebo (OR ¼2.82 vs. 1.69); the cause may be that stones were mainly located at distal ureter in Silodosin over tamsulosin group, while stones were located at proximal, middle, and distal ureter in Silodosin over placebo group. Two studies 15,19 reported the mean stone expulsion time was shorter in Silodosin than tamsulosin group, but the pooled results showed there was no difference because of different stone locations between the two studies, and the result should be carefully interpreted. In the Tsuzaka et al's study, 20 the mean stone size was 4.6 mm and 4.2 mm in naftopidil group and Silodosin group, respectively.…”

Section: Discussionmentioning

confidence: 97%

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The role of Silodosin as a new medical expulsive therapy for ureteral stones: a meta-analysis

et al. 2016

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To evaluate the efficacy of Silodosin as a medical expulsive therapy of ureteral stones, we searched PubMed, EMBASE, the Cochrane Library, and CBM up to June 2015. All randomized controlled trials (RCTs) were identified in which patients were randomized to receive Silodosin versus placebo or other therapies for ureteral stones. Outcome measures assessed were overall stone expulsion rate (primary) and expulsion time, analgesics times, and the incidence of additional treatment and regarding treatment complications (secondary). Two authors independently assessed study quality and extracted data. All data were analyzed using RevMan 5.3. Seven RCTs with a total of 1035 patients met the inclusion criteria. The pooled meta-analysis showed a significant improvement in stone clearance with Silodosin (Silodosin versus placebo, OR ¼1.69, 95% CI [1.19-2.40], p ¼ 0.003; Silodosin versus tamsulosin, OR ¼2.82, 95% CI [1.79-4.44], p < 0.00001). According to the size and location of ureteral stone, the pooling effects of Silodosin were analyzed, with a meaningful expulsion rate in distal ureteral stone when the size was 5-10 mm. In addition, a shorter expulsion time, fewer analgesics times, and additional treatments were observed. The common side effect was retrograde ejaculation. In summary, Silodosin appears to be more effective than either placebo or tamsulosin. Within the limits of available data, highquality multicenter RCTs are needed to thoroughly evaluate the outcome in the future. ARTICLE HISTORY

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Role of Tamsulosin, Tadalafil, and Silodosin as the Medical Expulsive Therapy in Lower Ureteric Stone: A Randomized Trial (a Pilot Study)

Cited by 63 publications

References 26 publications

Comparative Efficacy of Silodosin vs Tamsulosin for Ureteric Calculus: A Single Centre Double Blind Randomised Controlled Trial

Comparative Efficacy of Silodosin vs Tamsulosin for Ureteric Calculus: A Single Centre Double Blind Randomised Controlled Trial

Safety and efficacy of silodosin and tadalafil in ease of negotiation of large ureteroscope in the management of ureteral stone: A prosective randomized trial

The role of Silodosin as a new medical expulsive therapy for ureteral stones: a meta-analysis

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