Role of T2 mapping of magnetic resonance imaging in the differentiation of endometrial cancer and benign endometrial lesions

Abstract

The T2 mapping of magnetic resonance imaging (MRI) in endometrial cancer (EC), benign endometrial lesions (BELs), and normal endometrium (NE) has rarely been reported. This study aimed to determine the T2 values of MRI in EC, BELs, and NE to investigate whether the T2 values can differentiate them and to assess the aggressiveness of EC. METHODSIn total, 73 patients [EC, 51 (age, 57.4 ± 5.4 years); BELs, 22 (age, 57.8 ± 11.8 years)] and 23 normal volunteers (age, 56.1 ± 6.6 years) were included. The T2 values of MRI of the EC (type I and II), BEL, and NE groups were described and compared. The relationships between the T2 values of MRI in EC and the pathological characteristics [International Federation of Gynecology and Obstetrics (FIGO) stage and grade] were analyzed. RESULTSThe median T2 values of NE, BEL, and EC were 197.5 (142.9-324.0) ms, 131.1 (103.2-247.9) ms, and 103.0 (71.6-243.5) ms (P < 0.001), respectively. The median T2 values of type I and type II EC were 100.8 (71.62-130.44) ms and 125.7 (119.7-243.5) ms, respectively. There were significant differences in the T2 values among the NE, BEL, type I EC, and type II EC groups (P < 0.001) except for between the type II EC and BEL groups (P = 0.938). The T2 value of MRI in type I EC was significantly lower than that in type II EC (P = 0.001). There were no significant differences in patients with type I EC having different FIGO stages (P = 0.273) or tumor grades (P = 0.686). CONCLUSIONT2 mapping of MRI has the potential to quantitatively differentiate between EC, BELs, and NE as well as between type I and type II EC.

Multimodal MRI for Estimating Her-2 Gene Expression in Endometrial Cancer

“…Quantitative parametric imaging in MRI allows preoperative non-invasive assessment of the expression of EC Her-2 gene status. As a non-invasive MR imaging technique at the molecular level, APTw can reflect the metabolic and pathophysiological information of the lesion by measuring the quantitative parameter APT value [21,22]. Meanwhile, APTw signals can reflect protein and peptide content of tumor tissue [23], which increases with increased cell density, heterotypy, microvascular density (MVD), and microscopic necrosis of tumor tissue [24,25], resulting in increased APT values.…”

The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma

“…Ge et al (26) found that T2 mapping was highly effective in the quantitative detection of lymph node metastasis in rectal cancer. Regarding the uterine tumours, T2 values derived from T2 mapping have been shown to be valuable in the differentiation of cervical cancer, stage of LVSI, and benign and malignant endometrial lesions (27, 28).…”