Role of T cells in abscess formation

Tzianabos, Arthur O.; Kasper, Dennis L.

doi:10.1016/s1369-5274(02)00292-8

Cited by 34 publications

(25 citation statements)

References 16 publications

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“…Only recently, some of the cells and mechanisms involved in abscess formation by other pathogens, e.g., Staphylococcus aureus and Bacillus fragilis, were characterized (50). So far, formation of structural containments for bacteria has mainly been attributed to granulocytes, macrophages, and T cells (1,51,52).…”

Section: Discussionmentioning

confidence: 99%

“…So far, formation of structural containments for bacteria has mainly been attributed to granulocytes, macrophages, and T cells (1,51,52). T cells activate macrophages and polymorphonuclear cells, which then adhere to locally activated mesothelium, a requirement for the initiation of abscess formation (50). In acute murine listeriosis, granulocytes and macrophages play a major role in abscess formation in the liver, where DCs were shown to be absent (7).…”

Section: Discussionmentioning

confidence: 99%

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Indoleamine 2,3-dioxygenase–expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection

Попов¹,

Abdullah²,

et al. 2006

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Control of pathogens by formation of abscesses and granulomas is a major strategy of the innate immune system, especially when effector mechanisms of adaptive immunity are insufficient. We show in human listeriosis that DCs expressing indoleamine 2,3-dioxygenase (IDO), together with macrophages, are major cellular components of suppurative granulomas in vivo. Induction of IDO by DCs is a cell-autonomous response to Listeria monocytogenes infection and was also observed in other granulomatous infections with intracellular bacteria, such as Bartonella henselae. Reporting on our use of the clinically applied anti-TNF-α antibody infliximab, we further demonstrate in vitro that IDO induction is TNF-α dependent. Repression of IDO therefore might result in exacerbation of granulomatous diseases observed during anti-TNF-α therapy. These findings place IDO + DCs not only at the intersection of innate and adaptive immunity but also at the forefront of bacterial containment in granulomatous infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Indoleamine 2,3-dioxygenase–expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection

Попов¹,

Abdullah²,

et al. 2006

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“…They also do not share properties with classical superantigens as we initially hypothesized. These polysaccharides exhibit a particular charge pattern (38), which is characterized by alternating positive and negative charges and a minimal M r of ϳ17 kDa (39). How the Zps are sensed by the TCR FIGURE 4.…”

Section: Discussionmentioning

confidence: 99%

Zwitterionic Polysaccharides Stimulate T Cells with No Preferential Vβ Usage and Promote Anergy, Resulting in Protection against Experimental Abscess Formation

Stingele

Corthésy

Kusy

et al. 2004

The Journal of Immunology

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Zwitterionic polysaccharides (Zps) from pathogenic bacteria, such as Bacteroides fragilis, are virulence factors responsible for abscess formation associated with intra-abdominal sepsis. The underlying cellular mechanism for abscess formation requires T cell activation. Conversely, abscess formation can be prevented by prophylactic s.c. injection of purified Zps alone, a process also dependent on T cells. Hence, the modulatory role of T cells in abscess formation was investigated. We show that Zps interact directly with T cells with fast association/dissociation kinetics. Vβ repertoire analysis using RT-PCR demonstrates that Zps have broad Vβ usage. Zps-specific hybridomas responded to a variety of other Zps, but not to a nonzwitterionic polysaccharide, indicating cross-reactivity between different Zps. Furthermore, Zps-reactive T cell hybridomas could effectively transfer protection against abscess formation. Analysis of the proliferative capacity of T cells recovered from Zps-treated animals revealed that these T cells are anergic to subsequent stimulation by the different Zps or to alloantigens in an MLR. This anergic response was relieved by addition of IL-2. Taken together, the data show that this class of polysaccharides interacts directly with T cells in a nonbiased manner to elicit an IL-2-dependent anergic response that confers protection against abscess formation.

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“…However, both of these studies examined acute SA infections in contrast to the assessment of chronic disease described here. Furthermore, the infection routes (intraperitoneal) and the parameters used to assess disease were significantly different in both studies (20,70). These differences make it difficult to reconcile the antiinflammatory effects of Map described in a thioglycollate-induced peritonitis model with the abscesses and severe joint disease caused by a chronic SA infection (20).…”

Section: Figurementioning

confidence: 99%

The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell–mediated responses

Lee¹,

Miyamoto²,

McIntyre³

et al. 2002

J. Clin. Invest.

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Role of T cells in abscess formation

Cited by 34 publications

References 16 publications

Indoleamine 2,3-dioxygenase–expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection

Indoleamine 2,3-dioxygenase–expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection

Zwitterionic Polysaccharides Stimulate T Cells with No Preferential Vβ Usage and Promote Anergy, Resulting in Protection against Experimental Abscess Formation

The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell–mediated responses

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