Role of T-box transcription factor 3 in gastric cancers

Abstract

The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis. Considering its pivotal role in the initiation and progression of cancers, TBX3 could be a promising therapeutic target for gastric cancers.

An eco-friendly one-pot extraction process for curcumin and its bioenhancer, piperine, from edible plants in exosome-like nanovesicles

“…Considering the oral therapeutic potential of curcumin/piperine formulations for metabolic diseases, we also investigated the stability of ENVs in a simulated gastrointestinal digestion model in vitro. 71 Upon gastric-and intestinal-mimetic in vitro digestion, the size distribution of TENVs slightly shifted to a larger size likely due to aggregation of some ENVs (Fig. 9A).…”

Role of miR-155 gene expression in Rheumatoid arthritis

“…While another study explained that anti-CCP antibodies are produced in lymph nodes or ectopic lymphoid structures in synovial tissues, not in circulation, and that treatment affects the peripheral B-cell subpopulation and its ability to produce anti-CCP antibodies in patients with rheumatoid arthritis (RA), a transient increase in post-switch memory B cells after treatment may indicate that this is the case (30). This study by Julien and colleagues showed that miRNA155 is increased in patients with (RA) (31). Studies on related disorders have revealed that miRNA155 highly expressed may encourage the development of synoviocytes that resemble fibroblasts and secrete cytokines, which can impact the pathophysiology of RA.…”