Role of Systemic Inflammatory Indices in the Prediction of Moderate to Severe Bronchopulmonary Dysplasia in Preterm Infants

Çakır, Ufuk; Tayman, Cüneyt; Tugcu, Ali Ulas; Yildiz, Duran

doi:10.1016/j.arbres.2023.01.003

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…It has been reported that an SII level ≥78.2 after birth may be a risk factor for the development of RDS in preterms ≤32 weeks of gestation 15 . It was found that the high SIRI value could predict moderate to severe BPD in preterm infants 16 . According to these results, when using systemic inflammatory indices in the evaluation of neonatal diseases, it seems to be a more accurate approach to evaluate each index specific to the diseases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of systemic inflammatory indices in determining mortality in very low birth weight infants

Çakır¹,

Tayman²,

Tugcu³

2023

Rev. Assoc. Med. Bras.

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OBJECTIVE:In our study, we aimed to investigate whether systemic inflammatory indices could be an indicator of mortality in very low birth weight (<1,500 g) preterm infants. METHODS: Very low birth weight preterm infants were included in our study, and patient data were recorded retrospectively. Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, systemic immune-inflammation index, pan-immune-inflammation value, and systemic inflammation response index were calculated and recorded. The survivors and infants who died were compared for systemic inflammatory indices. RESULTS: A total of 1,243 very low birth weight infants were included in the study. Of the patients, 1,034 survived and 209 died. Neutrophil-tolymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, pan-immune-inflammation value, systemic immune-inflammation index, and systemic inflammation response index were found to be statistically significantly lower in the mortality group than those in the survivor group (p=0. 039, p=0.001, p<0.001, p<0.001, p<0.001, and p=0.002, respectively). According to the receiver operating curve analysis, systemic immuneinflammation index with the highest area under the curve (0.844) was found to be the most effective systemic inflammatory indices in predicting mortality with a cutoff level of ≤28.87 (p=0.0001). Multiple regression analysis showed that a lower level of systemic immune-inflammation index (≤28.87) was independently associated with mortality (OR: 1.677, 95%CI 1.061-2.685, p=0.001). CONCLUSION: We have shown that low systemic immune-inflammation index value in very low birth weight preterm infants may be a novel systemic inflammatory index that can be used to predict mortality.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of systemic inflammatory indices in determining mortality in very low birth weight infants

Çakır¹,

Tayman²,

Tugcu³

2023

Rev. Assoc. Med. Bras.

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“…In recent years, inflammatory parameters such as NLR, PLR, and SII have been used as an indicator in various diseases [27][28][29][30][31][32][33][34]. Karabulut et al [28] suggested that NLR and mean platelet volume (MPV) may be used in addition to conventional parameters such as CRP in the diagnosis and subsequent management of early-onset neonatal sepsis.…”

Section: Discussionmentioning

confidence: 99%

“…Li et al [29] demonstrated that there existed a relationship between NLR and the presence of neonatal sepsis. Cakır et al [30] suggested that systemic inflammation response index (SIRI) may be a useful biomarker for predicting moderate to severe bronchopulmonary dysplasia (BPD) and a marker of clinical importance in the follow-up of infants with BPD. In current study, although CRP levels are within normal limits, G6PD was negatively strongly correlated with NLR and SII.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Glucose 6-Phosphate Dehydrogenase and Pyruvate Kinase Deficiency with New Generation Inflammation Biomarkers of in Term Newborns with Prolonged Neonatal Jaundice

Okuyan,

Elgormus,

Dumur

et al. 2024

Preprint

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Background: Glucose 6-phosphate dehydrogenase (G6PD) deficiency increases the risk of neonatal hyperbilirubinemia. The aim of the study is to evaluate the clinical findings of glucose 6 phosphate dehydrogenase (G6PD) and pyruvate kinase (PK) deficiency, to prevent further examinations for prolonged jaundice, and to contribute by regulating its treatment. At the same time, it is to determine whether systemic-immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can be used in addition to conventional complete blood count (CBC) parameters in the diagnosis of neonatal prolonged jaundice. Methods: In full term neonates with hyperbilirubinemia who were admitted to Medicine Hospital between January 2019 and January 2024 with the complaint of jaundice, 167 infants with a serum bilirubin level above 5 mg/dL, whose jaundice persisted after the 10th day, were included in the study. Results: 63.5% of the patients were male and the mean age was 31±6 days. G6PD was negatively perfectly correlated with NLR (r: -1; p

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“…Several inflammatory markers, including the pan-immune-inflammation value (PIV), systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR) and C reactive protein (CRP), have been considered in the development and progression of inflammatory and infectious diseases. 6–10 Interestingly, studies have also identified positive associations between inflammatory markers, such as CRP 10–12 and NLR, 13 14 and the risk of LUTS, suggesting that inflammation may play an important role in the development of LUTS. For instance, prostate tissue samples taken from individuals with benign prostatic hyperplasia (BPH), a condition often associated with LUTS resulting from bladder outlet obstruction, commonly exhibit acute and chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Association between immune-inflammatory indexes and lower urinary tract symptoms: an analysis of cross-sectional data from the US National Health and Nutrition Examination Survey (2005–2008)

Liu,

Wang,

Wang

et al. 2024

BMJ Open

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ObjectiveThis study aimed to systematically investigate the relationship between immune-inflammatory indexes with lower urinary tract symptoms (LUTSs).DesignCross-sectional study.SettingNational Health and Nutrition Examination Survey (NHANES) (2005–2008).ParticipantsA total of 2709 men with complete information for immune-inflammatory indexes and LUTSs were included from NHANES 2005–2008.Outcomes and analysesAutomated haematology analysing devices are used to measure blood cell counts, and LUTSs were presented by standard questionnaires. Non-linear and logistic regression analyses were used to estimate their association after adjustment for confounders.ResultsMultivariate logistic regression showed that pan-immune-inflammation value (OR (95% CI)=1.60 (1.14 to 2.23)), systemic inflammation response index (SIRI) (OR (95% CI)=1.82 (1.21 to 2.73)), neutrophil/lymphocyte ratio (NLR) (OR (95% CI)=1.81 (1.31 to 2.49)), derived NLR (dNLR) (OR (95% CI)=1.91 (1.35 to 2.70)) and C reactive protein (CRP) (OR (95% CI)=1.71 (1.05 to 2.79)) was positively associated with LUTS. Additionally, composite immune-inflammation markers exhibited a stronger association with LUTS than any single index, with the ORs for high SIRI+high CRP, high NLR+high CRP and high dNLR+high CRP being 2.26, 2.44 and 2.16, respectively (all p<0.05). Furthermore, subgroup analyses revealed that age, smoking status and hypertension have different effects on the relationship between immune-inflammatory markers and LUTS.ConclusionsThis study indicated that high levels of immune-inflammatory markers were associated with an increased risk of clinical LUTS. The combination of CRP with SIRI, NLR and dNLR, respectively, showed a stronger positive correlation with clinical LUTS compared with any single index.

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Role of Systemic Inflammatory Indices in the Prediction of Moderate to Severe Bronchopulmonary Dysplasia in Preterm Infants

Cited by 7 publications

References 34 publications

Evaluation of the efficacy of systemic inflammatory indices in determining mortality in very low birth weight infants

Evaluation of the efficacy of systemic inflammatory indices in determining mortality in very low birth weight infants

Relationship between Glucose 6-Phosphate Dehydrogenase and Pyruvate Kinase Deficiency with New Generation Inflammation Biomarkers of in Term Newborns with Prolonged Neonatal Jaundice

Association between immune-inflammatory indexes and lower urinary tract symptoms: an analysis of cross-sectional data from the US National Health and Nutrition Examination Survey (2005–2008)

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