Role of systematic ultrasound‐guided staging biopsies in predicting extraprostatic extension and seminal vesicle invasion in men with prostate cancer

Okihara, Koji; Kamoi, Kazumi; Lane, Roger B.; Evans, Robert B.; Troncoso, Patricia; Babaian, R. Joseph

doi:10.1002/jcu.10052

Cited by 14 publications

(3 citation statements)

References 28 publications

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“…Although, TRUS images the entire prostate gland, in its current form, it cannot detect spatially localized or grade prostate adenocarcinoma. TRUS has low sensitivity for the detection of ECE and SVI [29,30]. It is most widely used to guide transrectal prostate biopsy.…”

Section: Mri Techniques For Prostate Cancer Detection and Localizationmentioning

confidence: 99%

Radical prostatectomy: value of prostate MRI in surgical planning

et al. 2011

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The introduction of serum prostate-specific antigen to the prostate cancer screening algorithm has led to an increase in prostate cancer diagnosis as well as a migration toward lower-stage cancer at the time of diagnosis. This stage migration has coincided with changes in treatment options; these include active surveillance, new therapies, and advances in surgical techniques. Use of robot-assisted radical prostatectomy (RARP) as a surgical technique has seen a significant increase over the past several years: the number of patients undergoing RARP has risen from 1% to 40% of all prostatectomies from 2001-2006 to as many as 80% in 2010. The robotic interface provides a 3D magnified view of the surgical field, intuitive instrument manipulation, motion scaling, tremor filtration, and excellent dexterity and range of motion. However, in some cases, the lack of tactile (haptic) feedback may limit the surgeon's decision making ability in assessing malignant involvement of the neurovascular bundles. Pre-operative planning relies on nomograms based on limited clinical and prostate biopsy information. The surgical decision to spare or resect the neurovascular bundles is based on clinical information which is not spatially or anatomically based. Advances in magnetic resonance imaging (MRI) may provide spatially localized information to fill this void and aid surgical planning, particularly for robotic surgeons. In this review, we discuss the potential role of pre-operative MRI in surgical planning for radical prostatectomy.

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Section: Mri Techniques For Prostate Cancer Detection and Localizationmentioning

confidence: 99%

Radical prostatectomy: value of prostate MRI in surgical planning

et al. 2011

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“…The magnitude of the problem can be expected to increase for several reasons: As *Address correspondence to this author at the Departamento de Medicina, Universidad de Cádiz, c/. Dr. Marañón, nº 3, 11002-Cádiz, Spain; Tel: +34-956-015324; Fax: +34-956-015280; E-mail: juanbosco.lopez@uca.es the average life expectancy is prolonged, the proportion of elderly in the population will increase, and this will result in an increased incidence of the disease, since it is directly related to age [4].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Methods in the Detection of Prostate Cancer: Prospective Observational Study

López-Sáez¹,

Otero²,

Dominguez‐Villar³

et al. 2007

CMIR

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Objective: The last decade has seen numerous modifications in the way the prostate cancer is diagnosed. Current diagnostic methods in prostate cancer lacking the ability to predict individual patient outcome, which highlights the need for more sensitive approaches. We investigated the value of digital rectal examination (DRE), transrectal ultrasonography (TRUS) and prostatic specific antigen (PSA) analysis as aids in general clinical practice and in the early detection of prostate cancer. The purpose of this paper is to evaluate the efficiency and effectiveness of analytical and imaging methods for diagnosing prostate cancer in the north-west Spain.Material and Methods: We investigated prospectively two groups of patients (in all 760) with pathological DRE or PSA. Sensitivity (Se), specificity (Sp), Positive predictive Value (PPV), Negative Predictive Value (NPV), Receiver Operating Characteristics (ROC) curves and other analyses were performed to determine the relative contributions of PSA, DRE, TRUS, Colour Doppler Ultrasound (CDUS), symptoms and patient age to cancer prediction.Results: The presence of prostatic disease symptoms did not distinguish between subjects with and without cancer (p=0.8450). The most sensitive (98%) was total PSA (>4 ng/ml) and the most specific were DRE (78%) and TRUS (65%). The contribution of PSA, DRE and TRUS to the diagnosis of prostate cancer was significant (p<0.05). In patients with a PSA of 4-10 ng/ml, using a threshold PSA specificity increased, using a free/total PSA ratio of 15%. Both echographic methods were effective (p<0.05), with greater specificity for CDUS.Conclusion: The PSA continues to be the most sensitive method for prostate cancer diagnosis. DRE tends to be more negative at early stages of cancer detection. Comparing the conventional TRUS echography with the CDUS, the latter is a better detector in the diagnosis of cancer.

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“…The magnitude of the problem can be expected to increase for several reasons: as the average life expectancy is prolonged, the proportion of the elderly in the population will increase, resulting in an increased incidence of the disease because it is directly related to age. 4 Pca is a remarkably heterogeneous disease. Some tumors are very small, well to moderately differentiated, and confined to the prostate.…”

mentioning

confidence: 99%

Prospective Observational Study to Assess Value of Prostate Cancer Diagnostic Methods

López-Sáez

Otero

Senra-Varela

et al. 2004

Journal of Diagnostic Medical Sonography

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The purpose of this article is to evaluate the efficiency and effectiveness of analytical and imaging methods for diagnosing prostate cancer in northwest Spain. The authors investigated prospectively two groups of patients with a pathological digital rectal examination (DRE) or prostate-specific antigen (PSA). Sensitivity, specificity, positive predictive value, negative predictive value, receiver operating characteristics curves, and other analyses were performed to determine the relative contributions of PSA, DRE, gray-scale transrectal ultrasonography (TRUS), color Doppler ultrasound (CDUS), symptoms, and patient age to cancer prediction. The presence of prostatic disease symptoms did not distinguish between subjects with and without cancer. The most sensitive (98%) was total PSA (> 4 ng/mL), and the most specific (78%) was DRE and TRUS (65%). The contribution of PSA, DRE, and TRUS to the diagnosis of prostate cancer was significant. In patients with a PSA between 4 and 10 ng/mL, PSA specificity increased, using a free/total PSA ratio of 15%. The PSA continues to be the most sensitive method for prostate cancer diagnosis. DRE tends to be more negative at early stages of cancer detection. Comparing the conventional TRUS echography with the CDUS, the latter is a better detector in the diagnosis of cancer.

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Role of systematic ultrasound‐guided staging biopsies in predicting extraprostatic extension and seminal vesicle invasion in men with prostate cancer

Cited by 14 publications

References 28 publications

Radical prostatectomy: value of prostate MRI in surgical planning

Radical prostatectomy: value of prostate MRI in surgical planning

Diagnostic Methods in the Detection of Prostate Cancer: Prospective Observational Study

Prospective Observational Study to Assess Value of Prostate Cancer Diagnostic Methods

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