Role of Survivin Gene Promoter Polymorphism (−31G&gt;C) in Susceptibility and Survival of Esophageal Cancer in Northern India

Upadhyay, Rohit; Khurana, Rohini; Kumar, Shaleen; Ghoshal, Uday C; Mittal, Balraj

doi:10.1245/s10434-010-1371-y

Cited by 47 publications

(40 citation statements)

References 37 publications

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“…Jaiswal et al (2011) have determined carrying homozygous C allele for -31 G/C polymorphism increases 2.6 fold risk of bladder cancer. Also, homozygous C allele for survivin -31 C/G has been shown that increased cancer risk in urothelial cancer (Wang et al, 2009), bladder cancer (Kawata et al, 2011), nasopharyngeal carcinoma (Ma et al, 2011), esophagus cancer (Upadhyay et al, 2011), prostate cancer (Chen et al, 2013) and colorectal cancer (Gazouli et al, 2009; studies. Yazdani et al (2012) also have demonstrated that GC and CC genotype distributions of survivin -31 G/C polymorphism were found statistically significant differences between thyroid cancer patients and controls.…”

Section: Discussionmentioning

confidence: 99%

Association Between Survivin Gene Polymorphisms and the Susceptibility to Colon Cancer Development in the Turkish Population

Yamak

Yaykaşlı²,

Yılmaz³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Colon cancer is one of the most common cancers worldwide. Apoptosis is a necessary physiological process for cell elimination which is very important both cellular homeostasis and cell proliferation and differantiation. Dysregulation can lead to uncontrolled cell growth and tumor development. Survivin, a member of the IAP family, plays a key role in promotion of cell proliferation as well as inhibition of apoptosis in cancer cells. The aim of this study was to investigate whether specific genetic polymorphisms of survivin could be associated with colon cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between colon cancer risk and survivin gene polymorphisms. Materials and Methods: The relation between colon cancer and survivin -31 G/C (rs9904341), -241 C/T (rs17878467) and -625 C/G (rs8073069) polymorphism in promotor site of survivin gene associated with apoptosis was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Individuals with -31C allele and CC genotype were found to have a higher risk of developing colon cancer (OR=13.4, p=0.01). The -241 CT genotype considerably increased the risk of colon cancer (OR=12.0, p=0.0001). However, there was no significant varaition of the survivin -625 C/G polymorphism among colon cancer patients and controls in our study. Conclusions: This study provides the first evidence that survivin -31 G/C and -241 C/T SNP significantly contribute to the risk of colon cancer in the Turkish population.

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Section: Discussionmentioning

confidence: 99%

Association Between Survivin Gene Polymorphisms and the Susceptibility to Colon Cancer Development in the Turkish Population

Yamak

Yaykaşlı²,

Yılmaz³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Survivin is highly expressed in various human malignancies, but its expression is very low or below the level of detection in normal adult tissues (Ambrosini et al, 1998;Yazdani et al, 2012). Survivin is usually expressed in the G 2 /M phase of the cell cycle, when it is thought to disrupt the apoptosis signaling pathways and to promote the survival of abnormal cells, offering a significant advantage to tumor cells overexpressing survivin (Upadhyay et al, 2011). The elevated expression of survivin is thought to be a negative prognostic factor for tumors and its overexpression is reported to be associated with shortened survival (Altieri, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Clarification of the survivin signaling pathway will provide new predictive and prognostic information for cancer diagnosis and could lead to the development of new therapeutic alternatives for a variety of cancers (Altieri, 2001;Yamamoto and Tanigawa, 2001). High survivin expression has been detected in several cancer types in humans, including colorectal cancer, hepatocellular cancer, lung cancer, pancreatic cancer, and osteosarcoma (Wang et al, 2009;Yang et al, 2009;Theodoropoulos et al, 2010;Upadhyay et al, 2011; Borges et al, 2011;Srivastava et al, 2012). Survivin is also expressed in breast cancer (Yamashita et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…The G > C mutation correlates with the increased expression of survivin at both the transcriptional and translational levels (Yazdani et al, 2012). Several case-control studies have examined the association between the -31G > C polymorphism and the risk of cancer (Srivastava et al, 2012), including nasopharyngeal carcinoma (Yang et al, 2009), esophageal cancer (Upadhyay et al, 2011), gastric cancer (Yang et al, 2009;Borges et al, 2011), hepatocellular carcinoma (Bayram et al, 2011), pancreatic cancer (Theodoropoulos et al, 2010), and urothelial carcinoma (Wang et al, 2009), but the results are controversial.…”

Section: Introductionmentioning

confidence: 99%

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The effect of survivin gene promoter polymorphism on breast cancer

Altiparmak¹,

Bilgiç²,

Dener³

et al. 2014

Turk J Biol

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Breast cancer is the most common malignant tumor in women and accounts for about 25% of all cancer diagnoses. Survivin is a member of the apoptosis inhibitor protein family of antiapoptotic proteins. In our study, we investigated one of those, the survivin gene promoter 31G/C polymorphism. Included in this study were 111 breast cancer patients who were operated on in our hospital and 101 healthy female subjects. Blood samples from the healthy subjects and paraffin-embedded tissue samples from the patients were used for DNA extraction and subsequent genetic analysis. PCR-RFLP was used for genotype analysis. We established the clinicopathologic characteristics of patients. No significant difference was found between survivin 31G/C promoter polymorphism of tumor characteristics and breast cancer. Between the control and breast cancer groups, survivin promoter polymorphism 31G/C differences were not significantly different (P = 0.058). The risk of developing cancer, having the relevant GC or CC genotype, is 1.413 times higher than those having genotype GG (95% confidence interval: 1.040 to 1.918). Carrying the C allele was statistically significant in terms of susceptibility to breast cancer. In conclusion, the use of survivin gene polymorphism as a risk factor in breast cancer is recommended based on the results of this study.

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“…12 Following this finding, researchers used in vitro promoter assays to demonstrate that the À31G allele had significantly lower transcriptional activity than the À31C allele, suggesting that the À31G/C polymorphism influences survivin expression, thus contributing to the genetic susceptibility to lung cancer. 13 Recently, many studies have investigated the role of the survivin À31G4C polymorphism in the etiology of various type of cancers, [13][14][15][16][17][18][19][20][21][22][23][24][25] including lung, gastric, bladder, esophageal, colorectal, urothelial, and pancreatic cancer. However, the results of these studies remain inconclusive.…”

Section: Introductionmentioning

confidence: 99%

Association between survivin −31G>C promoter polymorphism and cancer risk: a meta-analysis

Wang

Huang

et al. 2012

Eur J Hum Genet

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Survivin is an inhibitor of apoptosis protein and has a crucial role in the development of cancer. The survivin À31G4C (rs9904341) promoter polymorphism influences survivin expression and has been implicated in cancer risk. However, conflicting results have been published from studies on the association between survivin À31G4C polymorphism and the risk of cancer. To clarify the role of this polymorphism in cancer, we performed a meta-analysis of all available and relevant published studies, involving a total of 3485 cancer patients and 3964 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. The overall results indicated that the variant genotypes were associated with a significantly increased cancer risk (CC vs GG: OR¼1.58, 95% CI¼1.20-2.10; CC/GC vs GG: OR¼1.23, 95% CI¼1.00-1.51; CC vs GG/GC: OR¼1.51, 95% CI¼1.23-1.85). In the stratified analyses, significantly increased risk was associated with the Asian populations (CC vs GG: OR¼1.67, 95% CI¼1.16-2.40; CC vs GG/GC: OR¼1.50, 95% CI¼1.17-1.91). We also performed the analyses by cancer type, and no statistical association was observed. The results suggest that the survivin À31G4C promoter polymorphism might be associated with an increased risk of cancer, especially in the Asian populations.

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Role of Survivin Gene Promoter Polymorphism (−31G>C) in Susceptibility and Survival of Esophageal Cancer in Northern India

Abstract: Survivin promoter region polymorphism (-31G>C) is associated with susceptibility and clinical characteristics but not prognosis of esophageal cancer in northern Indian population.

Cited by 47 publications

References 37 publications

Association Between Survivin Gene Polymorphisms and the Susceptibility to Colon Cancer Development in the Turkish Population

Association Between Survivin Gene Polymorphisms and the Susceptibility to Colon Cancer Development in the Turkish Population

The effect of survivin gene promoter polymorphism on breast cancer

Association between survivin −31G>C promoter polymorphism and cancer risk: a meta-analysis

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