Role of surgical treatment in endometriosis

D’Alterio, Maurizio Nicola; Saponara, Stefania; D'Ancona, Gianmarco; Russo, Margherita; Laganà, Antonio Simone; Sorrentino, Felice; Nappi, Luigi; Angioni, Stefano

doi:10.23736/s2724-606x.21.04737-7

Cited by 22 publications

(21 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S2d). For all the endpoints described above, findings were consistent when analyzed using the PP set (assessed at weeks [4][5][6][7][8][9][10][11][12].…”

Section: Secondary and Exploratory Efficacy Endpointsmentioning

confidence: 70%

Assessment of Two Formulations of Triptorelin in Chinese Patients with Endometriosis: A Phase 3, Randomized Controlled Trial

Shi

et al. 2022

Adv Ther

View full text Add to dashboard Cite

Introduction: This phase 3, randomized, openlabel, active-controlled, multicenter study investigated the efficacy of triptorelin pamoate prolonged-release (PR) 3-month in Chinese patients with endometriosis by demonstrating the noninferiority of the 3-month formulation to the standard of care, triptorelin acetate PR 1-month. Methods: The trial was conducted in 24 clinical centers in China, and included 300 Chinese women (18-45 years) with endometriosis and regular menstrual cycles who required treatment with a gonadotropin-releasing hormone agonist for 6 months. One group of patients

show abstract

“…S2d). For all the endpoints described above, findings were consistent when analyzed using the PP set (assessed at weeks [4][5][6][7][8][9][10][11][12].…”

Section: Secondary and Exploratory Efficacy Endpointsmentioning

confidence: 70%

Assessment of Two Formulations of Triptorelin in Chinese Patients with Endometriosis: A Phase 3, Randomized Controlled Trial

Shi

et al. 2022

Adv Ther

View full text Add to dashboard Cite

show abstract

“…However, women without positive recall of their previous pregnancies were not included in the study. Finally, the statistical power of our study was not adequate to stratify the results according to the different phenotypes of endometriosis, i.e., deep, ovarian or peritoneal, nor to detect differences in obstetrical outcome between surgically [ 20 ] and medically treated women.…”

Section: Discussionmentioning

confidence: 95%

Impact of endometriosis on obstetric outcome after natural conception: a multicenter Italian study

Berlanda

Alio

Angioni

et al. 2021

Arch Gynecol Obstet

View full text Add to dashboard Cite

Purpose To evaluate obstetric outcome in women with endometriosis who conceive naturally and receive standard obstetric care in Italy. Methods Cases were consecutive women with endometriosis managed in eleven Italian referral centers. Controls were women in whom endometriosis was excluded. All women filled in a questionnaire addressing previous natural pregnancies. Marginal logistic regression models were fitted to evaluate the impact of endometriosis on obstetric outcome. A post hoc analysis was performed within the endometriosis group comparing women with severe adenomyosis versus women with absent or mild adenomyosis. Results Three hundred and fifty-five pregnancies in endometriosis group and 741 pregnancies in control group were included. Women with endometriosis had a higher risk of preterm delivery < 34 weeks (6.4% vs 2.8%, OR 2.42, 95% CI 1.22–4.82), preterm delivery < 37 weeks (17.8% vs 9.7%, OR 1.98, 95% CI 1.23–3.19), and neonatal admission to Intensive Care Unit (14.1% vs 7.0%, OR 2.04, 95% CI 1.23–3.36). At post hoc analysis, women with endometriosis and severe adenomyosis had an increased risk of placenta previa (23.1% vs 1.8%, OR 16.68, 95% CI 3.49–79.71), cesarean delivery (84.6% vs 38.9%, OR 8.03, 95% CI 1.69–38.25) and preterm delivery < 34 weeks (23.1% vs 5.7%, OR 5.52, 95% CI 1.38–22.09). Conclusion Women with endometriosis who conceive naturally have increased risk of preterm delivery and neonatal admission to intensive care unit. When severe adenomyosis is coexistent with endometriosis, women may be at increased risk of placenta previa and cesarean delivery. Trial registration Clinical trial registration number: NCT03354793.

show abstract

“…This modality is to ensure complete removal of all endometriotic lesions, avoid pelvic pain, recurrence, and fertility as well as preserve the functionality of the involved organs. 10 The radical approach involves segmental colorectal resection with or without a diverting stoma whereas conservative surgical options include rectal shaving, full-thickness rectal wall excision or disc resection, all of which are performed trans-anally. 11 There are various surgical devices procedures using resection including ultrasonic and plasma energy, cold scissors, and lasers, which over the years have advanced into using CO 2 , Nd:YAG, potassium titanyl phosphate, and the argon.…”

Section: Discussionmentioning

confidence: 99%

“…Surgery remains the mainstay of treatment for such cases and can be divided into either a radical or conservative approach. This modality is to ensure complete removal of all endometriotic lesions, avoid pelvic pain, recurrence, and fertility as well as preserve the functionality of the involved organs 10 . The radical approach involves segmental colorectal resection with or without a diverting stoma whereas conservative surgical options include rectal shaving, full‐thickness rectal wall excision or disc resection, all of which are performed trans‐anally 11 .…”

Section: Discussionmentioning

confidence: 99%

Surgery for deep infiltrating rectal endometriosis—Selecting the right approach

Jeyabalan

Ambikapathi

Subramaniam

et al. 2022

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Endometriosis involving the bowel is a form of deep infiltrating endometriosis (DIE). The endometriotic lesions can infiltrate the bowel layers mimicking a malignancy. The majority of bowel involvement happens in the colon and rectum. We report our experience in surgically managing rectal endometriosis in two patients, one via a conservative approach and the other with a more radical approach and their associated short-term and long-term outcomes are observed. In principle, surgery remains the mainstay of treatment in managing rectal DIE with adjuvant hormonal therapy. The selection of surgical approach should be based on disease factors such as the size of the lesions and extent of the disease, patient factors including fitness for surgery and expectations as well as logistics and resource limitations.

show abstract

Role of surgical treatment in endometriosis

Cited by 22 publications

References 88 publications

Assessment of Two Formulations of Triptorelin in Chinese Patients with Endometriosis: A Phase 3, Randomized Controlled Trial

Assessment of Two Formulations of Triptorelin in Chinese Patients with Endometriosis: A Phase 3, Randomized Controlled Trial

Impact of endometriosis on obstetric outcome after natural conception: a multicenter Italian study

Surgery for deep infiltrating rectal endometriosis—Selecting the right approach

Contact Info

Product

Resources

About