Role of surgical treatment for hepatolithiasis-associated intrahepatic cholangiocarcinoma: A retrospective study in a single institution

Zhu, Jisheng; Liu, Zhanying; Wan, Renhua; Li, Yong; Xiao, Weidong

doi:10.4103/jcrt.jcrt_356_17

Cited by 13 publications

(12 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CCA arises from bile duct epithelial cells, and there are three subtypes based on anatomic location: Intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA). The etiology of CCA includes lithiasis (2), primary sclerosing cholangitis (3), parasitic infection (4), congenital abnormalities (5), chronic liver disease (6), cirrhosis (6), metabolic abnormalities (7), and lifestyle (7). The incidence of iCCA appears to be increasing (8); the rates of CCA in North America, Japan, and Australia have been rising over the past two decades (9).…”

Section: Introductionmentioning

confidence: 99%

Aspirin inhibits cholangiocarcinoma cell proliferation via cell cycle arrest in vitro and in vivo

Shi

Fujita

et al. 2020

Int J Oncol

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Aspirin inhibits cholangiocarcinoma cell proliferation via cell cycle arrest in vitro and in vivo

Shi

Fujita

et al. 2020

Int J Oncol

View full text Add to dashboard Cite

“…1,2 The early symptoms of CCA associated with HL (HL-CCA) are not obvious, and they are easily confused with biliary inflammation caused by gallstones. 3,4 Accurate diagnosis of HL-CCA is challenging and it is usually at an advanced stage when diagnosed, which indicates a worse prognosis and treatment outcomes. In addition, studies have reported an increased incidence of concurrent CCA in patients with HL.…”

mentioning

confidence: 99%

<p>Identification of Cholangiocarcinoma Associated with Hepatolithiasis via the Combination of miRNA and Ultrasound</p>

Jiang¹,

Deng²,

Zhu³

et al. 2020

CMAR

View full text Add to dashboard Cite

Background: Identification of cholangiocarcinoma (CCA) associated with hepatolithiasis (HL) is difficult. There is no effective method to discriminate CCA associated with HL (HL-CCA) from HL currently. Objective: To explore the value of clinical data, ultrasonic characteristics and miRNA expression level in the identification of HL-CCA. Methods: Thirty-one patients with HL-CCA in Huazhong University of Science and Technology Union Shenzhen Hospital were enrolled in the observation group, while 40 patients with HL alone were included in the control group. The clinical data, ultrasonic characteristics, and miRNA expression level of the two groups were recorded and analyzed to explore the potential indicators for the identification of HL-CCA. Results: The accuracy of ultrasound in the diagnosis of HL-CCA was low (54.84%). Multivariate logistic regression analysis showed that liver abscess (P=0.021), indistinct border demarcation (P=0.015), non-homogenous echotexture (P=0.019), missed portal vein around lesion (P=0.032), miRNA-21 (P=0.018) and miRNA-221 (P=0.009) were the potential indicators for the identification of HL-CCA. The combined diagnosis based on logistic regression contained liver abscess, border demarcation, echotexture, portal vein around lesion, miRNA-21 and miRNA-221. The results showed that the accuracy of combined diagnosis identifying HL-CCA was the most accurate (AUC=0.911), which was significantly greater than the AUC of miRNA-21 or miRNA-221 individually (P<0.05), with a sensitivity and specificity of 77.42% and 97.50%, respectively. Conclusion: Patients with HL-CCA show high incidence of hepatic abscess and elevated miRNA-21 and miRNA-221 expression level. The ultrasonic features are more likely to show indistinct border demarcation, non-homogenous echotexture, and missed portal vein around lesion. The combined diagnosis is more accurate in the identification of HL-CCA.

show abstract

“…Hepatolithiasis is mainly caused by bacterial infection, parasites, bile stasis, anatomical variation, dietary structure, and genetics, with the pathological changes of hepatobiliary cholestasis, acute and chronic inflammation, inflammatory stenosis, and proximal dilation. [ 14 , 15 ] The accumulating stones in dilated bile ducts could further aggravate the obstruction, leading to repeated inflammation, abscesses, systemic sepsis, and even biliary ulceration. Hepatectomy is the main method to remove stones, correct bile duct stenosis, smooth bile duct drainage, and prevent disease recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…The conventional open hepatectomy and the emerging minimally invasive surgery are believed to be different in intraoperative blood loss, intestinal function recovery time, hospital stay, and postoperative complications, [ 5 , 16 , 17 ] which will also be evaluated by different meta-analysis. [ 12 , 14 , 18 , 19 ] However, in addition to surgical risks and short-term postoperative complications, long-term postoperative complications, stone clearance and recurrence, cholangitis recurrence, the need for reoperation, morbidity, and mortality are also important indicators for evaluating the efficacy.…”

Section: Discussionmentioning

confidence: 99%

Long-term efficacy and advantages of minimally invasive hepatectomy for hepatolithiasis

Jianyang

Xu²,

Luo

et al. 2020

Medicine

View full text Add to dashboard Cite

Background: Hepatolithiasis commonly occurs in the bile duct proximal to the confluence of the right and left hepatic ducts, regardless of the coexistence of gallstones in gallbladder or the common bile duct. Clinical research proves that minimally invasive surgery is effective in the treatment of hepatolithiasis. Although previous meta-analysis also shows that it could reduce intraoperative bleeding and blood transfusion, and shorten hospital stay time, there are few meta-analyses on its long-term efficacy. We conducted the meta-analysis and systematic review to systematically evaluate the long-term efficacy and advantages of minimally invasive hepatectomy in the treatment of hepatolithiasis. Methods: Articles of randomized controlled trials will be searched in the PubMed, Medline, Embase, Cochrane Library, China National Knowledge Infrastructure, Chongqing VIP Chinese Science and Technology Periodical Database, Chinese Biological and Medical database, and Wanfang database until September, 2020. Literature extraction and risk of bias assessment will be completed by 2 reviewers independently. Statistical analysis will be conducted in RevMan 5.3. Results: This study will summarize the present evidence by exploring the long-term efficacy and advantages of minimally invasive hepatectomy in the treatment of hepatolithiasis Conclusions: The findings of the study will help to determine potential long-term efficacy and advantages of minimally invasive hepatectomy in the treatment of hepatolithiasis. Ethics and dissemination: The private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences. OSF Registration number: DOI 10.17605/OSF.IO/H6WRV.

show abstract

Role of surgical treatment for hepatolithiasis-associated intrahepatic cholangiocarcinoma: A retrospective study in a single institution

Abstract: Radical resection is the most effective therapy for HL-iCCA. Regional lymphadenectomy is strongly recommended in resectable HL-iCCA, which is helpful in tumor staging and long-term survival.

Cited by 13 publications

References 1 publication

Aspirin inhibits cholangiocarcinoma cell proliferation via cell cycle arrest in vitro and in vivo

Aspirin inhibits cholangiocarcinoma cell proliferation via cell cycle arrest in vitro and in vivo

<p>Identification of Cholangiocarcinoma Associated with Hepatolithiasis via the Combination of miRNA and Ultrasound</p>

Long-term efficacy and advantages of minimally invasive hepatectomy for hepatolithiasis

Contact Info

Product

Resources

About