Role of supramolecular policosanol oleogels in the protection of retinyl palmitate against photodegradation

Tian, Yixing; Acevedo, Nuria C.

doi:10.1039/c9ra07820g

Cited by 10 publications

(1 citation statement)

References 37 publications

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“…Therefore, the intake of policosanol can be regulated by whole grains, nonpeeled fruits, or policosanol supplements. Aral administration of policosanol can significantly improve obesity and reduce triglyceride and cholesterol levels, whereas no significant toxicological effect has been reported in human and mouse models (Li et al., 2020; Tian & Acevedo, 2020). As indicated from the metabolic flow analysis, after the absorption into the body, policosanol is mainly distributed in the liver tissue, followed by adipose tissue and muscle, which demonstrates that its main target tissue is liver (Kabir & Kimura, 1995).…”

Section: Introductionmentioning

confidence: 99%

Policosanol alleviates hepatic lipid accumulation by regulating bile acids metabolism in C57BL6/mice through AMPK–FXR–TGR5 cross‐talk

Zhai

Niu

Liu

et al. 2021

Journal of Food Science

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Policosanol exhibits a lipid accumulation alleviating effect, but the underlying mechanisms remains unclear. Bile acids are a significant factor in regulating cholesterol and lipid metabolism homeostasis in mammals. This study was aimed to elucidate the alleviating effect and underlying mechanisms of policosanol on hepatic lipid accumulation through bile acid (BA) metabolism. Policosanol supplementation significantly reduced hepatic triglycerides (19.29%), cholesterol (30.38%) in high fat diet (HFD) induced obese mice (P < 0.05).Furthermore, compared with the control group, HFD decreased the levels of total BAs (TBAs, 37.67%) and cholic acid (CA, 62.74%) in the serum of mice (P < 0.05). Meanwhile, compared to HFD group, policosanol also increased the level of secondary BAs (SBAs) and muricholic acids (MCAs, P < 0.05).qRT-PCR combined with protein level analysis revealed that policosanol significantly decreased sterol regulatory element-binding protein (SREBP-1c) and CD36, and increased the expression level of cytochrome P450 family 7 subfamily A member 1 (CYP7A1) and cytochrome P450 Family 27 Subfamily A Member 1 (CYP27A1, P < 0.05). Additionally, in the liver, policosanol was found downregulated the expression of farnesoid X receptor (FXR)-small heterodimer partner (SHP), and activate the Takeda G-coupled protein receptor 5 (TGR5)adenosine-monophosphate-activated protein kinase (APMK) signaling pathway (P < 0.05). Peroxisome proliferator activated receptor (PPAR)-α, hormone sensitive lipase (HSL), and carnitine palmitoyltransferase (CPT)-1α also significantly increased in HP group (P < 0.05). The aforementioned results reveal that the potential mechanism of policosanol in alleviating liver lipid accumulation is to promote BA synthesis and lipolysis through regulating the cross-talk of the 5466

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Section: Introductionmentioning

confidence: 99%