Role of Sun Exposure in Melanoma

Abstract

The cause of melanoma is probably variable and multifactorial. Sun exposure may play a primary or supporting role in most melanoma tumors.

Regional differences in EpiPen prescriptions in the United States: The potential role of vitamin D

“…State-level data on average annual temperature, average annual precipitation, average January normal temperature, and average July normal temperature were obtained from the National Oceanic and Atmospheric Administration for 1971 to 2000. 11 Estimated 2004 melanoma incidence, an admittedly crude surrogate for sun exposure, 12,13 was obtained from the American Cancer Society. 14 …”

Sunscreens: An overview and update

“…[48][49][50] While sun protection is still recommended, its benefit may vary because of the role of individual genetic factors in melanoma development. 51 The multifactorial nature of melanoma may partly explain the inconsistent associations found between sunscreen use and melanoma development.…”

Melanoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology

“…In addition to genetic factors, environmental factors including excess sun exposure and UV-based artificial tanning contribute to the development of melanoma. [9][10][11] The interaction between genetic susceptibility and environmental exposure is illustrated in individuals with an inability to tan and fair skin that sunburns easily; these individuals have a greater risk of developing melanoma.12,13 However, melanoma can occur in any ethnic group and also in areas of the body without substantial sun exposure.As with nearly all malignancies, the outcome of melanoma depends on the stage at presentation.14 Experts estimate that, in the United States, 84% of patients with melanoma initially present with localized disease, 9% with regional disease, and 4% with distant metastatic disease. 15 In general, the prognosis is excellent for patients who present with localized disease and primary tumors 1.0 mm or less in thickness, with 5-year survival achieved in more than 90% of patients.…”

“…In addition to genetic factors, environmental factors including excess sun exposure and UV-based artificial tanning contribute to the development of melanoma. [9][10][11] The interaction between genetic susceptibility and environmental exposure is illustrated in individuals with an inability to tan and fair skin that sunburns easily; these individuals have a greater risk of developing melanoma. 12,13 However, melanoma can occur in any ethnic group and also in areas of the body without substantial sun exposure.…”