Abstract:Tubulointerstitial fibrosis (TiF) is an important pathological change that occurs during the development of diabetic kidney disease. The epithelial-mesenchymal transition (eMT) of renal tubular epithelial cells is a manifestation of TiF. STaT1, a member of the STaT family of transcription factors, can be modified by the small ubiquitin-related modifier (SUMO), thus affecting the activity of STAT1. The present study investigated the role of STaT1 SuMoylation in high glucose-induced tubular eMT by western blotti… Show more
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