Role of Sumac (Rhus coriaria L.) in the management of metabolic syndrome and related disorders: Focus on NAFLD-atherosclerosis interplay

Khalil, Mohamad; Hayek, Soukayna; Khalil, Nour; Serale, Nadia; Vergani, Laura; Calasso, Maria; Angelis, Maria De; Portincasa, Piero

doi:10.1016/j.jff.2021.104811

Cited by 21 publications

(17 citation statements)

References 134 publications

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“…It is recommended to use it at high temperatures [3]. Consumption of sumac can provide protection against atherosclerosis [14]. The antioxidant effect of sumac is 50 times stronger than that of vitamins C and E [15].…”

Section: Ofmentioning

confidence: 99%

Research and Development of Technology for Obtaining Red Food Coloring from Sumac Fruits

Hafizov¹

2023

Preprint

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In the East, it has already become a tradition to prepare dry powdered seasonings from the fruits of the sumac plant (Rhus coriaria L.). In this work, we tested their processing by extraction. Sumac was collected in mid-September in a mountain forest near the village of Gezik (Guba, Azerbaijan). Before extraction, it was first dehydrated in a drying cabinet SH-DO-149 FG (Southern Bark) to an air-dry state; then crushed in a Tube Mill control mill (Germany) into pieces of 1-3 mm in size. One- and two-stage maceration extraction was tested together with water or acidified water at temperatures from 20 to 80 °C. Evaporation of primary extracts was carried out in a rotary evaporator Lab Rot 2 L (China). The concentration of coloring substances in the extract (in units of optical density) was used as an output parameter. It was found that the use of two-stage extraction and acidified water with a concentration of citric acid 0.3 g/cm3 contributes to the extraction of the maximum amount of coloring substances and increases the transparency of the resulting extracts, which allows the extracted extracts to be concentrated directly to obtain a new type of natural food dye. The involvement of sumac fruits in industrial processing will increase the need for these medicinal fruits, and this, in turn, will serve as an incentive for the introduction of this medicinal plant into culture.

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Section: Ofmentioning

confidence: 99%

Research and Development of Technology for Obtaining Red Food Coloring from Sumac Fruits

Hafizov¹

2023

Preprint

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“…In younger subjects, low adherence to the MD can trigger functional gastrointestinal symptoms, as component of the irritable bowel syndrome and functional dyspepsia, mainly in younger subjects [ 217 ]. Unprocessed plant-based food such as fruits, vegetables, legumes, seeds, spices, and nuts, rich in polyphenols, are the principal aspect of the MD with a wide range of biological and pharmacological effects [ 218 , 219 , 220 , 221 ]. The polyphenols undergo biotransformation process by gut microbiota before reaching the liver by the portal vein with beneficial effects either locally (i.e., intestine) and systemically (i.e., liver, brain) [ 222 ].…”

Section: Diet Features and Effectsmentioning

confidence: 99%

“…Another biomarker for inflammation is C-reactive protein (CRP), and prolonged intake of the MD diminishes CRP and unusual quantity of cytokines and adipokines irrespective of weight loss increase [ 235 , 236 , 237 ]. Furthermore, the MD is associated with lower mortality and a decreased incidence of common chronic diseases such as CVD [ 238 ], several cancers [ 239 ], T2DM [ 240 ], fatty liver disease [ 241 ], and some types of allergies [ 242 ] as a result of the inhibition of oxidative stress, reduction in inflammation, and improved lipid profiles [ 218 , 219 , 243 , 244 , 245 ]. Along with improving physical health, long-term adherence to the MD also improves the quality of life and longevity [ 246 , 247 ].…”

Section: Diet Features and Effectsmentioning

confidence: 99%

The Potential of the Mediterranean Diet to Improve Mitochondrial Function in Experimental Models of Obesity and Metabolic Syndrome

et al. 2022

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The abnormal expansion of body fat paves the way for several metabolic abnormalities including overweight, obesity, and diabetes, which ultimately cluster under the umbrella of metabolic syndrome (MetS). Patients with MetS are at an increased risk of cardiovascular disease, morbidity, and mortality. The coexistence of distinct metabolic abnormalities is associated with the release of pro-inflammatory adipocytokines, as components of low-to-medium grade systemic inflammation and increased oxidative stress. Adopting healthy lifestyles, by using appropriate dietary regimens, contributes to the prevention and treatment of MetS. Metabolic abnormalities can influence the function and energetic capacity of mitochondria, as observed in many obesity-related cardio-metabolic disorders. There are preclinical studies both in cellular and animal models, as well as clinical studies, dealing with distinct nutrients of the Mediterranean diet (MD) and dysfunctional mitochondria in obesity and MetS. The term “Mitochondria nutrients” has been adopted in recent years, and it depicts the adequate nutrients to keep proper mitochondrial function. Different experimental models show that components of the MD, including polyphenols, plant-derived compounds, and polyunsaturated fatty acids, can improve mitochondrial metabolism, biogenesis, and antioxidant capacity. Such effects are valuable to counteract the mitochondrial dysfunction associated with obesity-related abnormalities and can represent the beneficial feature of polyphenols-enriched olive oil, vegetables, nuts, fish, and plant-based foods, as the main components of the MD. Thus, developing mitochondria-targeting nutrients and natural agents for MetS treatment and/or prevention is a logical strategy to decrease the burden of disease and medications at a later stage. In this comprehensive review, we discuss the effects of the MD and its bioactive components on improving mitochondrial structure and activity.

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“…Sumac with a fatty diet effectively decreased blood cholesterol and may possibly help in both prevention and treatment of hyperlipidemia in a small sample of white Wistar rats (Soltani et al, 2017). Clinical studies using sumac or its major constituents, proposed that this herbal product may represent an appropriate therapeutic tool in the management of metabolic-related conditions such as liver-atherosclerosis disorders (Khalil et al, 2021a). It has been reported that some active bio-active constituents of sumac have impacts against metabolic syndrome, such as Gallic acid on diabetes, obesity, NAFLD, oxidative-inflammatory damage; Methyl gallate on oxidative-inflammatory damage, cancer and obesity; Quercetin on obesity and hypertension, Myricetin on obesity and NAFLD; and Cyanidin, delphinidin on obesity, NAFLD, diabetes, and inflammation (Khalil et al, 2021a).…”

Section: Potential Health Benefits In Modern Pharmaceutical Sciencementioning

confidence: 99%

“…Clinical studies using sumac or its major constituents, proposed that this herbal product may represent an appropriate therapeutic tool in the management of metabolic-related conditions such as liver-atherosclerosis disorders (Khalil et al, 2021a). It has been reported that some active bio-active constituents of sumac have impacts against metabolic syndrome, such as Gallic acid on diabetes, obesity, NAFLD, oxidative-inflammatory damage; Methyl gallate on oxidative-inflammatory damage, cancer and obesity; Quercetin on obesity and hypertension, Myricetin on obesity and NAFLD; and Cyanidin, delphinidin on obesity, NAFLD, diabetes, and inflammation (Khalil et al, 2021a). Sumac fruit powder improved intestinal morphology of rainbow trout, and it may boost antioxidant status in rainbow trout, but dietary sumac fruit powder did not influence the serum biochemistry in rainbow trout (Diler et al, 2021).…”

Section: Potential Health Benefits In Modern Pharmaceutical Sciencementioning

confidence: 99%

Using sumac (Rhus coriaria L.), as a miraculous spice with outstanding pharmacological activities

Shahrajabian

Sun

2022

Not Sci Biol

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Sumac is the wine-colored ground spice, belonging to the cashew family (Anacardiaceae). The most important components of sumac ethanolic extract obtained from sumac are Trans-Caryophyllene, diethyl ester, Butanedioic acid, Cembrene, 1,7-Nonadien-4-ol,4,8-dimethyl, Malate, Palmitate, 9-Octadecenoic acid, Ethyl Linoleic acid, Phytol and Ethyl Linoleate. In the Middle East, sumac is used as a spice and is extensively consumed with Kebabs and grilled meats. It is traditionally used by native Indians of North America in the treatments of bacterial diseases, such as syphilis, gonorrhea, gangrene and dysentery. In traditional medicine of Middle Eastern countries, it has been used for cholesterol reduction and sweating because it has shown antibacterial, hypoglycemic activities and even antioxidant properties due to the presence of tannin fractions in both of their fruits and leaves. The most important health benefits of sumac are reduced cholesterol, balance blood sugar levels, rich in antioxidants, calms muscle aches, reduce the chance of bone depletion, and it can help in the fight against cancer. In this review article all relevant papers of different scholars and researchers were searched in Google Scholar, Science Direct, Scopus and PubMed. Sumac has numerous health benefits and important pharmacological activities, and it can be considered as a valuable source of nutraceuticals, and an efficient natural drug.

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Role of Sumac (Rhus coriaria L.) in the management of metabolic syndrome and related disorders: Focus on NAFLD-atherosclerosis interplay

Cited by 21 publications

References 134 publications

Research and Development of Technology for Obtaining Red Food Coloring from Sumac Fruits

Research and Development of Technology for Obtaining Red Food Coloring from Sumac Fruits

The Potential of the Mediterranean Diet to Improve Mitochondrial Function in Experimental Models of Obesity and Metabolic Syndrome

Using sumac (Rhus coriaria L.), as a miraculous spice with outstanding pharmacological activities

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