Role of substance P in immediate-type skin reactions induced by staphylococcal enterotoxin B in unsensitized monkeys

Involvement of substance P as a mediator in capsaicin-induced mouse ear oedema

“…Repeated application of capsaicin to monkey skin caused a significant reduction of cutaneous SP content and inhibition of neurally mediated increases in vascular permeability [21]. It has been reported that levels of SP in rat skin fall to approximately 50% of the normal value, 4 days after topical application of 33 mM capsaicin although afferent and efferent C-fiber function is normal [3].…”

The pharmacological profile of mouse hind paw inflammation induced by staphylococcal enterotoxin type A

“…Based on similarities between the possible mediators involved in the paw edema and neutrophil migration into the peritoneal cavity caused by SE type B (SEB) in mice [6,7] on the one hand, and the vomiting, the main symptom of food poisoning and experimental enterotoxemia caused by SE in monkeys [8][9][10][11][12], on the other, we have proposed that the phlogistic reaction in mice may serve as a valuable model for investigating the pathophysiologic mechanism of enterotoxemias.…”

Activation of mucosal Vβ3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B

“…This enterotoxic effect is thought to be related to the immediatetype skin reactions elicited in unsensitized monkeys by staphylococcal enterotoxin B (SEB) [2]. SEB induces neuropeptide release by sensory neurons [3] which in turn causes massive mast cell degranulation and mediator release .The rapid onset of symptoms after ingestion of SEB is also consistent with this notion. However, SE are also powerful T cell superantigens, able to stimulate, when presented by class I1 major histocompatibility complex molecules on antigen-presenting cells, subsets of T cells that use certain Vp gene segments of the T cell antigen receptor (TCR) [4, 51.…”