Role of Subplasmalemmal Mitochondria in Angiotensin II–Mediated Contraction

Sheldon, Kely L.; Martín, Alejandra San

doi:10.1161/circresaha.115.307795

Cited by 1 publication

(2 citation statements)

References 31 publications

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“…Although production of ROS by mitochondria appears to be an independent process under most conditions, recent reports indicate that ROS production by mitochondria can promote ROS production by the extramitochondrial NADPH oxidase system, or vice versa, via a positive feedback system (23,31,37,134,138). Thus, the interaction between the mitochondria and the cytosolic NADPH oxidase axis leads to cellular damage due to excessive production of ROS by a "ROS induced ROS" mechanism.…”

Section: Mitochondrial Energetics and Reactive Oxygen Species Productionmentioning

confidence: 99%

“…Mitochondria located near the inner plasma membrane surface appear to mediate this response (24). The best example of this interaction occurs with the exposure of vascular and nonvascular cells to angiotensin II (24,31,37,38,134). Hypertension can cause increased mitochondrial-mediated ROS stress in the cerebral vasculature (38).…”

Section: Mitochondrial Energetics and Reactive Oxygen Species Productionmentioning

confidence: 99%

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Role of Mitochondria in Cerebral Vascular Function: Energy Production, Cellular Protection, and Regulation of Vascular Tone

Busija

Rutkai

Dutta

et al. 2016

Comprehensive Physiology

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Mitochondria not only produce energy in the form of ATP to support the activities of cells comprising the neurovascular unit, but mitochondrial events, such as depolarization and/or ROS release, also initiate signaling events which protect the endothelium and neurons against lethal stresses via pre-/postconditioning as well as promote changes in cerebral vascular tone. Mitochondrial depolarization in vascular smooth muscle (VSM), via pharmacological activation of the ATP-dependent potassium channels on the inner mitochondrial membrane (mitoKATP channels), leads to vasorelaxation through generation of calcium sparks by the sarcoplasmic reticulum and subsequent downstream signaling mechanisms. Increased release of ROS by mitochondria has similar effects. Relaxation of VSM can also be indirectly achieved via actions of nitric oxide (NO) and other vasoactive agents produced by endothelium, perivascular and parenchymal nerves, and astroglia following mitochondrial activation. Additionally, NO production following mitochondrial activation is involved in neuronal preconditioning. Cerebral arteries from female rats have greater mitochondrial mass and respiration and enhanced cerebral arterial dilation to mitochondrial activators. Preexisting chronic conditions such as insulin resistance and/or diabetes impair mitoKATP channel relaxation of cerebral arteries and preconditioning. Surprisingly, mitoKATP channel function after transient ischemia appears to be retained in the endothelium of large cerebral arteries despite generalized cerebral vascular dysfunction. Thus, mitochondrial mechanisms may represent the elusive signaling link between metabolic rate and blood flow as well as mediators of vascular change according to physiological status. Mitochondrial mechanisms are an important, but underutilized target for improving vascular function and decreasing brain injury in stroke patients. © 2016 American Physiological Society. Compr Physiol 6:1529-1548, 2016.

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Section: Mitochondrial Energetics and Reactive Oxygen Species Productionmentioning

confidence: 99%

Section: Mitochondrial Energetics and Reactive Oxygen Species Productionmentioning

confidence: 99%

Role of Mitochondria in Cerebral Vascular Function: Energy Production, Cellular Protection, and Regulation of Vascular Tone

Busija

Rutkai

Dutta

et al. 2016

Comprehensive Physiology

View full text Add to dashboard Cite

show abstract

Role of Subplasmalemmal Mitochondria in Angiotensin II–Mediated Contraction

Cited by 1 publication

References 31 publications

Role of Mitochondria in Cerebral Vascular Function: Energy Production, Cellular Protection, and Regulation of Vascular Tone

Role of Mitochondria in Cerebral Vascular Function: Energy Production, Cellular Protection, and Regulation of Vascular Tone

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